Thiotepa

Expression of Pgp , GST π are more efficacious than Topo ⅱ α index to predict the sensitivity to intravesical chemotherapy with thiotepa or MMC .

在预测以塞替派和丝裂霉素为主的术后腔内化疗敏感性方面，Pgp、GST-π表达情况较Topo-α指数更为有效。

Objective To observe the mutation of related genes during the process of malignant transformation induced by a chemotherapeutic agent thiotepa in the immortalized human bronchial epithelial cell line ( BEAS 2B ) .

目的观察抗癌药物塞替派诱发永生化人支气管上皮细胞恶性转化过程中相关基因的突变并分析其意义。

Objective To investigate the malignant transformation effects of human bronchial epithelial cells induced by thiotepa .

目的研究塞替派对人类支气管上皮细胞的致癌转化效应。

Conclusion Thiotepa has a serious malignant transformation effect on immortalized human bronchial epithelial cells .

结论塞替派对人支气管上皮细胞具有较强的恶性转化效应。

A pharmacodynamic study of thiotepa and mitomycin C on human bladder cancer cell line in vitro

体外膀胱灌注噻替哌和丝裂霉素C的药效学研究

Therapeutic effect of regular submucous injection of thiotepa in preventing relapse of superficial bladder cancer

浅表性膀胱移行细胞癌粘膜下定期注射噻替哌预防复发近期疗效观察

Observation on hyperthermia combined with intravesical thiotepa instillation for prevention recurrence of superficial bladder carcinoma after operation

高频透热合并膀胱灌注噻替哌预防表浅性膀胱癌复发的疗效观察

Conclusions 0.05 % Thiotepa Eye Drops had markedly cytotoxic effects against human cancer cells and human normal cells , no exhibited selective inhibition .

结论Thiotepa滴眼液对各种细胞有明显的生长抑制作用；0.05%Thiotepa滴眼液对各种人癌细胞和正常细胞均有强的细胞毒作用，且对人癌细胞无明显的选择性抑制作用。

There was drug resistance to mitomycin C , Thiotepa , 5-Fluorouracil , Vincristine , and Methotrexate at average inhibition rate less than 30 % .

而对丝裂霉素C、噻替哌、5氟尿嘧啶、长春新碱和氨甲喋呤则耐药，平均抑制率均小于30%。

The longevity and mating duration of males would be decreased with the increasing of concentration of thiotepa , when treated by different concentrations of thiotepa in different stages of G. cantor .

在眉斑并脊天牛的不同时期进行不同浓度噻替派水溶液处理时，随着噻替派浓度的增加，雄虫的寿命和交配持续时间均呈缩短趋势。

Mutation of p16 ~ ( INK4a ) and p15 ~ ( INK4b ) genes of human bronchial epithelial cells malignantly transformed by cyclophosphamide and thiotepa

环磷酰胺及塞替派诱导的人支气管上皮恶性转化细胞的p16~（INK4a）及p15~（INK4b）基因突变