PD-1

Study on performance improvement of PD-1 electronic clinical thermometer

PD-1型电子体温计性能改进的研究

Activated T cells and B cell express PD-1 .

活化的T细胞与B细胞表达PD-1。

Clinical Significance of PD-1 in Human Hepatocellular Carcinoma

肝细胞癌患者PD-1表达及其临床意义研究

Influence of PD-1 on T cell immunity in the course of chronic HCV infection

PD-1分子对慢性丙型肝炎患者T细胞免疫功能的影响

Preparation of two mouse anti-human PD-1 monoclonal antibodies and identification of their biological characteristics

两株鼠抗人PD-1单克隆抗体的制备及其生物学特性鉴定

PD-1 / PD-L1 is one of important negative costimulatory molecules .

PD-1/PD-L1是一对重要的负性协同刺激分子。

Exploration of the Role of PD-1 / PD-L1 Pathway in HBV Infection

PD-1/PD-L1通路在HBV感染中作用的研究

Studies of the Mechanism and Effect of PD-1 on the Aberrant Regulation of T Cells in Aplastic Anemia

PD-1对再生障碍性贫血T细胞功能异常的作用及其机制研究

Therefore , tumor target therapy via specifically blockage of the inhibitory PD-1 / PD-L1 pathway is expected .

因此，特异性阻断PD-1/PD-L1抑制途径有望成为肿瘤靶向治疗的策略之一。

So we will continue to study the roles of PD-1 / PD-L1 at those neural cells in detail after SCI .

因此在接下来的研究中，我们将分别对PD-1、PD-L1分子在各个神经细胞中的作用进行详细研究。

PD-1 plays a negative regulatory role when combining with its ligands named PD-L1 / PD-L2 during immune response .

PD-1与其两个配体PD-L1和PD-L2结合，在免疫应答中起着负性调控作用。

Study of Prevalence Rate Status of Chronic Hepatitis B and PD-1 / PD-L1 Signal Passway to be the Immunotherapy Target for Hepatitis B

慢性乙肝患病状况调查与PD-1/PD-L1信号通路作为乙肝免疫治疗靶位的研究

The role of PD-1 and it 's ligand PD-L1 / PD-L2 in the parasitic infection immune

PD-1及其配体PD-L1/PD-L2在寄生虫感染免疫中的作用

Electrostatic-probe plasma Diagnoses System PD-1

PD-1静电探针等离子体诊断系统

Isolation and physiology of a strain PD-1 of Methanobacterium formicicum

甲酸甲烷杆菌PD-1的分离及其生理性状

PD-1 is a receptor of B7-H1 and is shown to mediate the inhibition of activated T cell response , presumably by inhibiting cell cycle progression .

PD-1是B7-H1的受体，可以通过调节细胞周期而抑制活化T细胞的反应。

Animal experiments showed that PD-1 signal deficient could develop lupus-like glomerulonephritis and arthritis in mice , and leading to autoimmune diabetes with rapid progress in NOD mice .

动物实验显示，PD-1信号缺失导致小鼠发生类风湿关节炎及狼疮样自身免疫性肾炎，导致NOD小鼠自身免疫性糖尿病的快速进展。

Conclusion The hPD-1-Fc chimeric molecule is constructed and expressed successfully , which provides base for further investigation of the role of PD-1 in immune tolerance and autoimmune disease .

结论成功构建了hPD1Fc重组表达载体，利用哺乳动物细胞CHO表达出有活性的hPD1Fc融合蛋白，为进一步研究PD1分子在免疫耐受、自身免疫性疾病中的作用奠定了基础。

The antagonists of B7-H1 can be applied to block the transmission of inhibitory signals in B7-H1 / PD-1 pathway , as might become a new target for cancer immunotherapy .

使用B7-H1拮抗剂可以阻断B7-H1/PD-1通路传递的抑制信号，可能成为胃癌免疫治疗新靶点。

The abnormal high expression of sPD-L1 in the peripheral blood of lung cancer patients showed that the factor further depressed the immune function , so that antigen-specific PD-1 + T cells disabled .

sPD-L1在肺癌患者外周血中异常高表达表明该因子进一步抑制了机体的免疫功能，使抗原特异性PD-1+T细胞失能。

After the transfection of recombinant into mammalian CHO cell by lipofectamine reagent , the expression of PD-1 fusion protein was detected in the cultured CHO cell supernatant by the sandwich ELISA .

重组质粒转染CHO细胞后，夹心ELISA法检测显示培养上清液中有hPD1Fc蛋白表达。

The railway wagon with different axle loads running on 60 kg / m PD-1 tangent rail is simulated in laboratory , and the effects of axle load on the wear of wheel and rail are analyzed .

采用模拟试验方法，在试验室内模拟不同轴重货车运行于60kg/m直线PD-1钢轨情况，研究轴重对轮轨磨损的影响。

The expression of PD-1 in gastric cancer was mainly CD8 + T cells , high expression of PD-1 T-lymphocyte proliferation and cytokine secretion capacity were reduced , so the function of PD-1 + T-lymphocyte is suppressed .

胃癌中表达PD-1主要是CD8+T细胞，高表达PD-1的T淋巴细胞增殖能力和分泌细胞因子能力均降低，因此PD-1+T淋巴细胞功能受到抑制。

Objective : B7-H1 , a member of B7 family of co-stimulatory molecules , is involved in regulation of T cell function and cytokine secretion through the PD-1 / non-PD-1 receptor on T and B cells .

目的：B7-H1是共刺激分子B7家族新成员之一，通过与T和B细胞表面的PD-1和非PD-1受体结合参与T细胞功能调节和细胞因子分泌。

Increasing in PD-1 negative costimulatory signals decreased T cells infiltration and inflammatory reaction in AS rabbit plaque ; relieved experimental autoimmune encephalitis and infiltration of macrophages , CD4 + , CD8 + T cells in spinal cord .

增加PD-1负性共刺激信号可使AS兔粥样斑块中T细胞浸润减少及炎性反应减轻，减轻实验性脑脊髓膜炎（EAE）程度，使脊髓浸润的巨噬细胞、CD4+、CD8+T细胞消失。

Objective To investigate the role of programmed death-ligand 1 ( PD-L1 ) in the pathogenesis of type ⅳ lupus nephritis ( LN ) and its correlation with programmed death-1 ( PD-1 ) and the severity of tubulointerstitial lesions .

目的了解Ⅳ型狼疮肾炎（LN）患者肾组织中程序性死亡配体-1（PD-L1）、程序性死亡-1（PD-1）的表达及PD-L1与PD-1、肾小管间质病理损害程度的关系。

The interaction between PD-1 and PD-L1 suppress the proliferation and activation of autoreactive T cells , which could significantly inhibit the secretion of IL-1 , IFN - γ and IL-10.The oxidative stress caused by hyperglycemia induces the dysfunction of endothelial cells , causing the deposition of lipid in blood-vessel .

PD-L1能与其负性受体PD-1相互作用抑制T细胞的增殖和活化，尤其能显著降低IL-1、IFN-γ和IL-10等细胞因子的分泌。血糖升高所致的氧化应激使血管脂质沉积，引起血管内皮细胞功能障碍。