IRES

VPg is served as the primer of duplication . One of researching focus is the study on Poly ( C ) and IRES in 5 ′ - UTR .

VPg可能充当RNA合成引物的作用，5′UTR内的Poly（C）和内部核糖体进入位点（internalribosomaentrysite，IRES）是当前研究的热点之一。

Hepatitis C Virus IRES Gene Cloning by T Vector and Sequencing

丙型肝炎病毒IRES基因T载体克隆及序列分析

Research on Structure and Function of DHV-1 Internal Ribosome Entry Site ( IRES ) Elements

DHV-15'UTR内部核糖体进入位点的结构与功能研究

Structural modeling of HCV IRES specific inhibitor RNA and its inhibitory effect on viral translation in vitro

HCVIRES特异性抑制性RNA结构模拟及在体外对病毒翻译启动的抑制作用

Poly ( C ) may be relative with virulence and IRES plays important role in initiation of translation .

Poly（C）可能与病毒的感染性有关，IRES对翻译的起始有重要作用。

Quantitive analysis of the inhibition of HCV IRES mediated HCV core protein expression in cells by inhibitor RNA

抑制性RNA对细胞内HCVIRES介导HCV核心蛋白表达抑制作用的定量分析

A novel approach by combining Internet topology generation and routing protocol implementation is proposed , and the architecture of IRES is presented .

首先提出了一种将Internet拓扑生成和路由协议实现相结合的思想，并基于此给出了IRES的总体结构。

The basic and secondary structure of the sequence between poly ( C ) and IRES regions in foot-and-mouth disease virus genome

口蹄疫病毒基因组IRES和Poly（C）之间功能未知区一级和二级结构分析

Bicistronic expression vectors , containing internal ribosomal entry sites ( IRES ), can simultaneously express two different antigens .

双顺反子表达载体含有核糖体内部进入位点，因此可同时表达两种不同的抗原。

The Basic and Secondary Structures of IRES in Foot-and-Mouth Disease Virus Strain China / 99 and Alignment with That of Reference Strains

口蹄疫病毒基因组内部核糖体进入位点一级和二级结构分析

Internal ribosome entry site ( IRES ) is crucial for hepatitis C virus ( HCV ) expression and replication .

核糖体内部进入位点（IRES）是丙型肝炎病毒（HCV）基因表达和复制的关键。

This demonstrated that polycistronic retroviral vector containing IRES could efficiently express multiple therapeutic genes in the same target cell .

实验结果表明，含IRES的多顺反子逆转录病毒载体能很好地在同一靶细胞中表达多个外源基因。

Conclusions The wild Russula virescens from Yunnan Ires distinct effects on regulation of blood lipid and antioxidation .

结论云南野生青头菌具有明显的调节血脂及抗氧化作用。

Advances on IRES Element of Picornavirus mRNA

小RNA病毒蛋白翻译调控元件研究进展

Our purpose is to take IRES as the target site , utilize RNAi and Dz activity for the treatment of HCV infected disease .

本研究的目的是以IRES作为HCV基因治疗的作用靶位，应用RNA干扰技术和脱博士学位论文中文摘要氧核酶技术进行抗丙型肝炎核酸药物研究。

Aim To study the inhibitory activity of IRES specific inhibitory RNA ( IRNA ) on HCV IRES mediated protein translation in vitro .

目的研究IRES特异性抑制性RNA（IRNA）对HCVIRES介导蛋白翻译的体外抑制作用。

Construction of retroviral vector carrying the IRES linked tumor necrosis factor alpha and interferon beta cDNAs under the control of HLA-B7 inducible promoter

人类HLA-B7可诱导启动子调控IRES连接的人TNFα和IFNβ基因的重组逆转录病毒载体的构建

Today the gene therapeutic methods aiming for HCV IRES include oligonucleotide strategy ( antisense and ribozyme methods ) and IRES specific inhibitor RNA ( IRNA ) methods .

目前针对该区域的基因治疗策略主要包括寡核苷酸策略（反义核酸策略和核酶策略）和IRES特异性抑制性RNA（IRNA）策略。

Methods Recombinant adenovirus was used as vector , TNF - α and IFN - β were connected through IRES and HLA-B7 promoter was selected to control their expression .

方法以腺病毒为载体，以IRES连接TNF和IFN基因，选择HLAB7可诱导启动子调控其表达。

We also study the influence factors on the function of IRES , such as IFN , alcohol , PTB , La antigen , and HCV non-structure protein et al .

同时探讨了影响IRES功能的各种因素，如IFN、酒精、PTB、La蛋白以及HCV的几种非结构蛋白等。

In order to test the influence of these mutations on IRES function , we transfected these mutants into BHK-21 cells , and observed the expression of downstream report gene in vivo .

为了验证这些突变对IRES功能的影响，我们将这些突变体分别转染BHK-21细胞，观察其在体内条件下对下游报告基因的启动情况。

Now , different approaches , such as internal ribosomal entry site ( IRES ) elements , bidirectional or double promoters , or coinfection with multiple viral vectors are commonly used .

目前，常用的多基因共表达方法有内核糖体进入位点（IRES）元件载体、双向或双启动子共表达、多个质粒共转染及多病毒载体共感染等。

Objective : To construct a recombinant adenovirus vector which express mouse TGF β 1 and PLP Ig independently ligated by internal ribosome entry sites ( IRES ) sequence .

目的：以内部核糖体进入位点（IRES）序列连接鼠TGF-β1和PLP-Ig2基因，构建重组腺病毒双表达载体。

This paper discusses some researches on the application of wavelet analysis in diagnosing several fault types of infrared earth sensors ( IRES ), gyros and jet engines of GNC subsystem in manned spaceship .

本文利用小波分析优良的时频特性处理载人飞船测量数据，针对GNC系统红外地球敏感器、陀螺和姿控发动机的几种故障模式，进行了故障诊断的尝试。

On top of these studies , the authors now show that the variants map to known RNA functional elements , such as internal ribosome entry sites ( IREs ) and upstream ORFs .

除此，研究者还公布了突变的定位已便知晓RNA的功能原件，例如核糖体结合位点（IREs）和上游开放阅读框。

In this study , we assemble a positive feedback loop for the production of T7 RNA polymerase using basic molecular elements , including CMV promoter , T7 promoter and the internal ribosomal entry site ( IRES ) .

在本课题中，利用基本的分子生物学元件，如CMV启动子、T7启动子、和内部核糖体进入位点（IRES）等，我们组装了一个T7RNA聚合酶的正反馈表达系统。

The internal ribosome entry site ( IRES ) sequence was derived from encephalomyocarditis virus . It allows to translate two open reading frames at one mRNA , so two genes conjoined by IRES have the same expression rate .

内部核糖体进入位点（IRES）序列来源于脑心肌炎病毒，它可翻译一条mRNA上的两个开放读框，由其连接的两个基因的表达率相同。

Methods : with bovine β - casein promotor , a fusion gene both S and M and co-expressive nucleic vaccine plasmid were constructed which two genes were conjoined by the internal ribosome entry site ( IRES ) .

方法：通过两种方法应用牛β酪蛋白启动子构建S和M融合基因表达载体以及构建IRES连接M和S双基因共表达核酸疫苗载体。

Aim : In order to increase major histocompatibility complex class I molecule expression on the tumor cells and prime an efficient antitumor immunity , A retroviral Vector containing the IRES linked HuTNF α and IFN β genes under the control of human HLA-B7 inducible promoter was constructed .

目的：为增强肿瘤细胞表面MHCⅠ类分子表达，并调动免疫系统更有效地抑制和杀伤肿瘤细胞，构建在HLA-B7启动子调控下，IRES连接的人TNFα和IFNβ基因的重组逆转录病毒载体。