Genomic imprinting

The Evolutionary Foundation of Genomic Imprinting in Lower Vertebrates

低等脊椎动物中存在基因组印迹进化的基础

It has profound effects on biological processes in mammals , including gene expression and developmental regulation , differentiation , genomic imprinting , X chromosome inactivation and biological defense etc. .

研究表明，DNA甲基化对哺乳动物中诸多生物学过程有着深刻的影响，可能参与基因的表达调控，发育调节，细胞分化，基因组印迹，X染色体灭活和生物防御等。

Study on the Mechanism of Cell Memory for Mammalian Genomic Imprinting

哺乳动物基因组印记的细胞记忆机理初探

The Effects of Genomic Imprinting on Animal Development and Cloning

基因组印记对个体发育及动物克隆的影响

CONCLUSION : The genomic imprinting plays an important role in the vertical transmission of tic disorders .

结论在抽搐性运动障碍的垂直传递中遗传印迹起了重要作用。

DNA methylation is involved in various biological processes including tissue-specific gene expression , genomic imprinting .

DNA甲基化与许多生物学过程有关，包括组织特性基因的表达，基因组印记。

Objective To investigate whether genomic imprinting is involved in the etiology of tic disorder .

目的研究遗传印迹是否与抽动障碍的遗传病因学有关。

A vertical relation between tic disorder and genomic imprinting

抽搐性运动障碍与遗传印迹垂直关系的研究

Genomic imprinting ( genetic imprinting ) refers to parent of origin dependent gene expression .

基因组印记（又称遗传印记）是指基因根据亲代的不同而有不同的表达。

At present , most studies on genomic imprinting are in human and mouse but little in livestock .

目前，对基因组印记的研究主要集中在人和小鼠中，在家畜特别是猪中研究比较少。

Genomic imprinting is a special hereditary phenomenon out of line with Mendel 's law .

基因组印记（Genomicimprinting）是不符合孟德尔遗传定律的特殊遗传现象。

This article reviews the mechanisms of genomic imprinting and several commonly imprinted genes in human and mouse .

综述基因组印记的可能发生机制及人和鼠中常见的印记基因。

Study of Genomic Imprinting

遗传印记现象的研究

Recent Advance of Genomic Imprinting in Mammal

哺乳动物基因组印记的研究进展

The role of genomic imprinting in the human genetic diseases , particularly in the tumor is causing more and more attention .

基因印迹在人类遗传性疾病尤其是肿瘤发生中的作用正引起越来越多的关注。

Our study was to explore the genomic imprinting of IGF - ⅱ in prostate cancer and its correlation to disease progression .

本研究拟检测晚期前列腺癌组织中IGF-Ⅱ的印迹状态，并探讨印迹基因丢失与疾病进展的关系。

DNA Methylation And Genomic Imprinting

DNA甲基化与基因组印记

However , there are still many problems to be solved , such as absence of genomic imprinting of the infant , which needs to be studied further .

但辅助生殖技术仍存在许多问题，如胎儿出生后遗传印记的缺失，其机制还有待进一步研究。

AIM : To investigate the vertical relation of tic disorder with genomic imprinting , and to explore whether there is sex difference in its penetrance .

目的研究抽搐性运动障碍与遗传印迹的垂直传递的关系，探讨其外显率是否存在性别差异。

The results of these researches have provided an important basis for the final explanation of the mechanism of BWS and the genetic feature and biological significance of genomic imprinting .

这些研究结果为最终阐述BWS的发病机理和基因组印记的遗传学特征与生物学意义提供了重要依据。

Conclusion Parental specific expression exists in the transmission of tic disorder , which gives evidence that genomic imprinting may be involved in the genetic mechanism of tic disorder .

结论抽动障碍的传递存在亲源特异性表达，抽动障碍病因学中可能存在遗传印迹机制。

Genomic imprinting is an epigenetic mechanism that produces functional differences between the paternal and maternal genomes and plays an essential role in mammalian development and growth .

基因组印记是由于父源或母源的等位基因受到“标记”而发生的不符合孟德尔遗传定律的特殊遗传现象。

In addition , because genomic imprinting belongs to the category of epigenetics , some genes which were involved in epigenetic modification were quantitatively analyzed .

另外，由于基因组印记属于表观遗传学的范畴，本实验还对胚乳中参与调控表观遗传修饰的有关基因进行了定量表达分析。

Role of Genomic Imprinting and Osteopontin in Human Lung Cancer Genomic imprinting of insulin-like growth factor ⅱ in colorectal cancer and its relationship with the presence of metastasis

胰岛素样生长因子-2、H19、MEST基因印迹与骨桥蛋白在肺癌发生机制中作用的研究IGF-Ⅱ基因表达与结直肠腺癌浸润转移的关系

The methylation of histone H3-K27 was proved to be linked to several silencing phenomena including homeotic-gene silencing , X inactivation and genomic imprinting .

组蛋白H3第27位赖氨酸的甲基化与同源盒基因沉默、X染色体失活、基因印记等基因沉默现象有关；

The reason why there is the unique process of genomic imprinting in filial generation is that a gene on one chromosome is expressed , whereas its allele on the other chromosome is silenced .

“遗传印记”现象是由于子代体内来自父母双方的等位基因一方表达、另一方沉默造成的。

DNA methylation regulates critical biological phenomena such as X-chromosome inactivation , genomic imprinting , chromatin structure and regulation of gene expression . What is more , it has been shown to be essential for cell differentiation and embryo development .

DNA甲基化调控着重要的生物学现象，比如X染色体的失活、遗传印记、染色质结构以及基因表达，并且在细胞分化和胚胎发育过程中也起着极其重要的作用。

Genomic imprinting is a phenomenon that the gene is expressed primarily or exclusively from either the maternal or paternal allele and plant imprinting has been described primarily in endosperm . It plays a role in regulating endosperm development and affecting seed size .

基因组印记是后代仅表达亲本单拷贝基因的现象，植物印记主要发生在胚乳，具有调控胚乳发育及影响种子大小的作用。

Methylation and demethylation of DNA are the complementary processes of epigenetic regulation . Methylation and demethylation influence a diverse array of cellular activities , including X chromosome inactivation , genomic imprinting , chromatin modification , and the silencing of endogenous genes .

DNA甲基化与去甲基化是表观遗传调控的两种重要调节方式，其在X染色体失活、基因组印迹、染色质修饰和内源性基因沉默等过程中发挥重要作用。

In the past few fears , there has been a nascent convergence of scientific understanding of human disease with epigenetic . Identified epigenetic processes involved in human disease include chromatin remodeling , genomic imprinting , X chromosome inactivation , and noncoding RNAs regulation .

在过去的几年里，人们对表观遗传疾病的机理有了新的认识，这些疾病与染色质重塑、基因组印记、X染色体失活以及非编码RNA调控这4个表观遗传过程相关。