CD40L

The expressions of T cell CD40L in KD patients were prolonged compared with normal control .

在体外培养系统中川崎病患儿T淋巴细胞CD40L表达较正常对照持久。

These results suggested the possibility that CD40L may also inhibit MCL proliferation in vivo .

这些结果提示CD40L在活体内可能对MCL增殖有抑制作用。

The expression of CD40 / CD40L during chronic rejection of renal allograft in rats

大鼠移植慢性排斥组织中CD40和CD40L表达研究

The Biological Effect of Human Multiple Myeloma Cells Expressing CD40L / CD40 and CD40 Mutants

CD40L/CD40及CD40突变体在人多发性骨髓瘤中的表达及其生物学意义

Conclusion The soluble human CD40L truncate expressed in prokaryotic cells showed inhibiting effect on the growth of tumor cells .

结论原核表达的截断型人可溶性CD40L具有抑制肿瘤细胞生长作用。

The association between hypertensive complications and serum levels of soluble CD40 / CD40L in patients with cardiovascular diseases

高血压并发症与患者血清可溶性CD40及CD40L水平的关系

CD40 / CD40L plays a crucial part in immune response , and proves wide application in the immune therapy of leukemia .

CD40/CD40L在免疫应答中起关键作用，广泛应用于白血病的免疫治疗。

AIM : To clone and express the recombinant human soluable CD40 ligand ( CD40L ) with biological activation .

目的：克隆并表达有生物学活性的CD40配体（CD40ligand，CD40L）重组蛋白。

Progress of correlation between CD40 / CD40L and interleukin-8 and monocyte chemotactic protein-1 in inflammatory tissue

炎症组织中CD40/CD40L与白细胞介素-8和单核细胞趋化蛋白-1的相关性

Results : M231 and ECV cell line and fresh clinic breast cancer cell are highly expressed CD40 but no CD40L .

结果：CD40高表达于乳腺癌细胞株M231、乳腺癌新鲜标本及血管内皮细胞，上述3种细胞基本不表达CD40L。

The role of CD40L 、 IL-10 and IL-17 in radioprotection

CD40L、IL-10和IL-17的辐射防护作用

Compared to placebo group , simvastatin can inhibit the vascular intima proliferation The expression of PAPP-A and CD40L were also decreased significantly .

与安慰剂组比较，辛伐他汀组内膜增生减少，而管腔面积的减少减轻，与之相对应的是PAPP-A的表达及血管组织CD40L蛋白含量也明显降低。

Objective : To evaluate the effect of aspirin and clopidogrel on development of atherosclerosis and CD40-CD40 ligand ( CD40L ) .

目的：观察阿司匹林和氯吡格雷对动脉粥样硬化病变进展的影响，并探讨抗血小板治疗抑制CD40CD40配体（CD40L）系统的作用。

Correlation between Peroxisome Proliferator-activated Receptor Gamma and CD40 / CD40L in Atherosclerotic Monocyte / Macrophage

动脉粥样硬化单核/巨噬细胞过氧化物酶体增生激活型受体γ和CD40/CD40L的相关性研究

AIM : To explore the effects of CD40-CD40 ligand ( CD40L ) interaction on endothelial cells ( ECs ) procoagulant activity .

目的：探讨CD40-CD40配体（CD40L）相互作用对内皮细胞促凝活性的影响。

Designing of Novel Molecules Based on B7 / CD40L and Their Roles in Induction of Anergy and Prolongation of Survival of Allografts

基于B7/CD40L的新分子设计及其在诱导免疫失能和延长移植物存活中的作用

The Expression of Co-stimulators CD40 / CD40L and OX40 / OX40L and Their Biological Roles in Human Breast Cancer

共刺激分子CD40/CD40L和OX40/OX40L在乳腺癌中的表达及其生物学意义

Among them , CD40 / CD40L and B7-1 / CD28 have been studied fully in both super-families .

其中B7／CD28和CD40／CD40L是两个家族中最典型也是目前研究报道最多的分子。

In addition , peripheral immune tolerance can be obtained by blocking the conduction of B7 / CD28 and CD40 / CD40L specifically .

另外，通过特异性阻断协同刺激信号B7/CD28以及CD40/CD40L的传导，可获得外周性免疫耐受。

Objective To investigate the molecular mechanism of vasular cess adhesion molecule-1 ( VCAM-1 ) expression induced by CD40 / CD40L system in ECV-304 cells .

目的研究人类脐静脉内皮细胞（ECV-304）、CD40/CD40L系统诱导血管细胞黏附分-1（VCAM-1）表达的分子机制。

CD40 / CD40L and B7-1 / CD28 participate in renal tubular epithelial cell injury , immunocompetent cell infiltration and renal tubulointerstitial fibrosis .

结论在小鼠叶酸性肾病中，肾组织CD40/CD40L和B7-1/CD28的表达上调并参与了肾小管上皮细胞损伤、免疫活性细胞浸润和肾小管间质纤维化的过程。

Objective To investigate the expression of platelet-derived CD40 ligand ( CD40L ), P-selectin ( CD62P ) in peripheral blood and its clinical significance in asthma .

目的探讨血小板源性CD40配体（CD40L）、血小板P选择素（CD62P）在哮喘患者外周血中的表达及其临床意义。

But it is short of further exploration in the correlation between matrix metalloproteinase and CD40L or risk stratification and predicting the value of heart incidence in unstable angina .

但在不稳定性心绞痛患者中，基质金属蛋白酶的水平与CD40L的相关性以及与不稳定性心绞痛患者的危险度分层、发生心脏事件的预测价值方面尚缺乏进一步的探索。

Objective To study the role of costimulatory molecules CD28 / B7 and CD40 / CD40L in asthma patients and the expression levels before and after specific immunotherapy .

目的探讨协同刺激分子CD28/B7-1、CD28/B7-2及CD40/CD40L在哮喘发病中的作用及在特异性免疫治疗前后表达水平的变化。

CD40 is a pivotal costimulatory molecule in immune response , and with its ligand ( CD40L ) transduces the second signal the activation of T and B cell needs .

CD40是免疫应答中关键性的共信号分子，其与配体（CD40L）的相互作用提供T、B细胞活化所必需的第二信号。

Objective To investigate potential mechanisms by which CD40 - CD40 ligand ( CD40L , CD154 ) interaction may be involved in the pathogenesis of immunodeficiency and renal injury in haemodialysis patients .

目的探讨CD40-CD40配体（CD154）相互作用在血液透析患者免疫异常及肾脏损伤中的可能作用。

The interaction between CD40 and its ligand ( CD40L ) is not only confined in signal convection in inflammatory cell , but also involve in the regulation of inflammatory reaction of main cells in atherosclerosis .

CD40与其配体（CD40L）相互作用不只局限于炎症细胞之间信号传递，还参与AS内主要细胞成分（包括血管内皮细胞、血管平滑肌细胞、巨噬细胞等）的炎症反应调节。

Objective : To investigate the effect of cytokines ( IFN γ, TNF and IL 1 ) on the expression of CD40 and CD40 ligand ( CD40L ) in monocytes / macrophages .

目的：探讨细胞因子γ干扰素（IFN-γ）、肿瘤坏死因子（TNF）和白介素-1（IL-1）对人单核/巨噬细胞表达CD40和CD40L的影响。

Without costimulatory molecules , such as CD28 , CD40L and CTLA-4 , or upon blockage of costimutory signal , T cells can not be effectively activated or proliferate properly .

针对已知的几种共刺激分子（CD28、CD40L、CTLA-4等）的研究数据表明，缺乏共刺激分子或用适当的手段阻断共刺激信号途径，T细胞不能有效的活化和增殖。

Objective To obtain CD40 Ig fusion protein , and investigate the therapeutic potentials of blocking the CD40 / CD40L signal pathway in the prevention and treatment of graft versus host disease ( GVHD ) .

目的建立稳定表达CD40Ig融合蛋白的工程细胞株，获得大量融合蛋白以研究靶向阻断CD40∶CD40L途径防治移植物抗宿主病（GVHD）策略的应用潜力。