Azlocillin

A preparation method of azlocillin sodium was established .

本文报道阿洛西林钠盐的制备工艺。

Isolation and determination of high molecular weight impurities in azlocillin

阿洛西林中高分子杂质的分离测定

HPLC method for determination of azlocillin in biological samples

生物样品中阿洛西林的HPLC测定

Headspace Gas Chromatography Determination of Residual Organic Solvents in Azlocillin Sodium

顶空气相色谱法测定阿洛西林钠的有机溶剂残留量

Study on Stability of Azlocillin Sodium For Injection in 5 % Xylitol Injection

注射用阿洛西林钠在5%木糖醇注射液中的稳定性考察

Observation of the stability of azlocillin sodium in infusion fluids by orthogonal test

正交法考查阿洛西林钠在输液中的稳定性

Study on the pharmacokinetics and bioavailability of domestic azlocillin

国产阿洛西林人体药动学、生物利用度研究

Objective To prepare Azlocillin sodium .

目的制备阿洛西林钠。

Determination of azlocillin sodium for injection by FIA

流动注射分析测定注射用阿洛西林钠的含量

In Vitro Antibacterial Activity of Azlocillin in Combination with Tazobactam against 168 Strains of Pathogenic Bacteria

阿洛西林与他唑巴坦联用对168株致病菌的体外抑菌活性研究

Azlocillin was not stable to all 13 plasmid or chromosome induced β lactamases .

本品对质粒和染色体介导的β－内酰胺酶均不稳定。

Results : The contents of azlocillin sodium with different concentrations in above-mentioned solutions at different temperatures had no obvious changes over 0 ~ 8 h.

结果：配伍液在上述各温度、不同浓度的输液中，0~8h内阿洛西林钠含量均无显著性的变化。

Preparation of Azlocillin sodium

阿洛西林钠的制备

Results : There was no evident changes in appearance and pH , the content of azlocillin sodium was over 98 % of the initial concentration in five intravenous admixtures within 6 hours .

结果：在25℃和37℃6h内配伍液外观澄明，无颜色改变，pH值变化不大，在五种输液中6h内阿洛西林钠的相对百分含量均>98%。

Object : To observe the stability of azlocillin sudium with different concentrations in 5 % glucose injection , glucose and sodium chloride injection and sodium chloride injection at 4 ℃, 25 ℃ and 37 ℃ over different periods .

目的：在4、25和37oC条件下，考查不同浓度的阿洛西林钠与5%葡萄糖注射液、葡萄糖氯化钠注射液、氯化钠注射液在不同时间的配伍稳定性。

The in-vitro activity of China-made azlocillin was evaluated against 446 pathogenic organisms isolated from patients of our hospital from 1980 to 1988 , and was compared with the same antibiotic produced by Miles Pharmaceuticals U. S. A and 6 other antibiotics .

本文报道国产阿洛西林对1980～1988年重庆地区临床分离的446株致病菌的体外抗菌活性，并与美国Miles药厂生产的同类产品进行比较。

All 8 strains of metallo - β - lactamases-producing bacteria were resistant to β - lactams antibiotics and antibiotics containing β - lactamases inhibitors or Imipenem . Only was it rather sensitive to Azlocillin , Amikacin and Ciprofloxacin .

8株产金属酶细菌对β内酰胺类抗生素、含β内酰胺酶抑制剂的复合抗生素及亚胺培南全部耐药，仅对氨曲南、阿米卡星及环丙沙星较敏感。

Results The MIC50 / MIC90 of azlocillin against Streptococcus pneumoniae , Haemophilus influenzae and methicillin-sensitive Staphylococcus aureus ( MSSA ) was 0.06 / 2,0.06 / 0.5 and 2 / 8 , respectively . The susceptibility of these three species against azlocillin was all 100 % .

结果阿洛西林对肺炎链球菌、流感嗜血杆菌和甲氧西林敏感的金黄色葡萄球菌（MSSA）的MIC50/MIC90分别为0.06/2、0.06/0.5和2/8，三种细菌对阿洛西林的敏感率均高达100%。