齐墩果酸

HPLC法测定地泽胶囊中齐墩果酸的含量

Determination of Oleanolic Acid in Dize capsules by HPLC

HPLC测定木瓜果醋中齐墩果酸含量

Study on the Content of Oleanolic Acid in Chinese Flowering Quince Fruit Vinegar by HPLC

齐墩果酸对肝DNA和蛋白质合成速率的影响

The Effects of OLA on the Synthetic Rate of DNA and Protein in Hepatocytes of Mice

齐墩果酸型人参皂甙R0对心肌细胞单钙通道活动与自由基含量的影响

Influence of oleanolic acid type ginsenoside Ro on single calcium channel activity and free

目的：以怀牛膝的子叶为外植体，以愈伤指数与齐墩果酸含量优选最佳MS培养基。

Objective : To select the best MS medium .

HPLC测定车前草提取物中熊果酸、齐墩果酸的含量

Determination of ursolic acid and oleanolic acid in plantago major extractive matter by HPLC

齐墩果酸三萜配糖体2DNMR的研究

2D NMR studies on oleanolic acid triterpenoid glycosides

目的：研究通脉活络康颗粒中齐墩果酸的HPLC定量分析方法。

Objective : To establish a HPLC method for determination of oleanolic acid in Tongmai Huoluokang granules .

HPLC法测定陆英花和果实中齐墩果酸和熊果酸的含量

Determination of Ursolic Acid and Oleanolic Acid in Flowers and Fruits of Sambucus Chinensis Lindl . by HPLC

HPLC法测定毛萼香茶菜不同药用部位中熊果酸和齐墩果酸的含量

HPLC determination of oleanolic acid and ursolic acid in different parts of Rabdosia eriocalyx ( Dunn ) Hara

发酵过程中总黄酮、维生素C、齐墩果酸含量明显下降，但相对含量仍很高。

The above data suggested that the content of total flavone , vitamin C and oleanolic acid decreased obviously during the fermentation but their relative content remained high .

RP-HPLC法测定竹节参药材中齐墩果酸的含量

Determination of Oleanolic Acid in Panax japonicus by RP-HPLC

齐墩果酸型皂甙1种，即人参皂甙Ro，它们的结构已被确定。

Oleanolic acid type saponin one is a ginsenoside Ro .

建立了测定番石榴叶中齐墩果酸和熊果酸的气相色谱-质谱（GC-MS）方法。

A gas chromatographic-mass spectrometric method for determining oleanolic and ursolic acid has been developed .

齐墩果酸对人肺腺癌细胞A549增殖与细胞周期的阻滞作用

Effect of oleanolic acid on proliferation and cell cycle block of human lung adenoma A549

齐墩果酸固体分散体胶囊的溶出度测定及Weibull分析

Dissolution Property of Oleanolic Acid from three preparations Determined by HPLC and Analyzed by Weibull 's Model

齐墩果酸诱导人肺腺癌细胞A549凋亡及其与细胞内钙离子的关系

Apoptosis induced by oleanolic acid and its relation to intracellular calcium of human lung adenoma A549 cells

对宣木瓜叶进行TLC定性研究，发现其中含有具有活性的齐墩果酸。

Qualitative research on leaves in Chinese flowering quince was done by TLC , and activated oleanolic acid was found .

五环三萜类化合物&齐墩果酸（oleanolicacid）、18β-甘草次酸（18β-Glycyrrhetinicacid）和熊果酸（UrsolicAcid）广泛分布于植物界，显示出多种生物活性。

Oleanolic acid , 18 β - glycyrrhetinic acid and ursolic acid , as pentacyclic triterpenoids , are ubiquitous in the plant kingdom and exhibit various biological activities .

目的观察甘草甜素（GL）和齐墩果酸（OA）对大鼠亚慢性镉中毒性肾损害组织病理形态的影响。

Objective To observe effects of glycyrrhizin and oleanolic acid on renal histopathological changes induced by subchronic cadmium exposure in rats .

宣木瓜酒发酵过程中主要成分含量的变化结果表明，主发酵前维生素C为95.2mg/100g、总黄酮16.3mg/100g、齐墩果酸135mg/100g。

Before primary fermentation , the content of vitamin C , total flavone and oleanolic acid in the wine were 95.2 mg / 100 g , 16.3 mg / 100 g and 135 mg / 100 g respectively .

齐墩果酸也能明显激活酪氨酸酶（P＜0.01），促进黑素合成（P＜0.05），并使黑素细胞TYR和TRP-1mRNA表达量分别比加入无水乙醇的对照增加31.88%和17.73%；

Oleanolic acid also could increase tyrosinase activity and melanogenesis , and compared with its control , the mRNA level of TYR and TRP-1 increased 31.88 % and 17.73 % respectively ;

结论齐墩果酸具有抑制MCF-7细胞增殖和诱导调亡的作用；

Conclusions : Oleanolic acid have the effects of the inhibition of MCF-7 cell proliferation and induction of the cell apoptosis .

目的：建立应用RP-HPLC测定当药及不同部位中獐牙菜苦苷、当药苷、龙胆苦苷和齐墩果酸的含量测定方法。

Objective : To establish a RP-HPLC method for the determination of swertiamarin , sweroside , gentiopicrin and oleanolic acid in different parts of Swertia pseudochinesis .

用HPLC法测定不同种和不同器官中均含有齐墩果酸，但含量在种间有较大差异，且以花中含量最高。

The contents of oleanolic acid in 12 species of plants are determinated by HPLC , but among the different plants and botanical organs their contents are different , and the highest content in flowers .

采用HPLC法进行齐墩果酸的检测，研究了木瓜中齐墩果酸的提取方法，发现以无水酒精等有机溶剂提取效果最好。

The content of oleanolic acid was detected by HPLC and the extraction method of oleanolic acid from Chinese floweringquince was investigated . The optimal extraction results were got with organic solvent such as water-free ethanol .

结果：制得齐墩果酸固体脂质纳米粒形态均匀圆整、粒径范围为（62.0±10.3）nm，包封率为98.29%，载药量为8.17%。

RESULTS : The appearance of prepared solid lipid nanoparticles was regular with the diameter being ( 62.0 ± 10.3 ) nm , the encapsulation efficiency was 98.29 % and the loading rate was 8.17 % .

此外，通过补加葡萄糖和流加H2O2的方式考察齐墩果酸羟基化的反应机理，佐证了齐墩果酸羟基化反应是单加氧酶催化反应。

The mechanism of oleanolic acid hydroxylation was studied by investigation of the effects of feeding glucose and H2O2 . The results showed that this hydroxylation process was catalyzed by monooxygenase ;

试验结果表明：峰面积RSD（相对标准差值）均小于2.5%，乌索酸和齐墩果酸平均回收率分别为98.32%（RSD为2.12%）和97.92%（RSD为1.69%）。

RSD were all less than 2.5 % . The average recoveries of ursolic acid and oleanolic acid were 98.32 % ± 2.12 % and 97.92 % ± 1.69 % , respectively .

检测波长：210nm。熊果酸和齐墩果酸回归方程的相关系数分别为0.9999，0.9997；

The correlation coefficients of ursolic acid and oleanolic acid were 0.9999 and 0.9997 ;