转录调控

基因表达和调控是植物基因工程研究的重要内容，而启动子在决定基因表达方面起着转录调控中心的作用，它在很大程度上决定着目的基因表达的时间、空间和强度。

Gene expression and regulation is an important part of plant genetic engineering , moreover , the promoter play an central role of transcriptional regulation , which largely determines gene expression in time , space and intensity .

组蛋白上广泛发生的精氨酸甲基化修饰与基因的转录调控，细胞周期调控以及DNA损伤修复等过程都密切相关。

Arginine methylation broadly occurs in histones and has been linked to transcriptional regulation , cell cycle regulation and DNA repair .

基因组中具有调控功能的DNA序列片段可称为转录调控元件。

The DNA segments which have certain regulatory function in genomic sequences are called transcriptional regulatory elements .

人DNA聚合酶kappa的转录调控研究

Transcriptional Regulation of Human DNA Polymerase Kappa

AFM观察小鼠心肌核DNA转录调控和蛋白质相互作用

Observation of Transcription Regulation in the Mouse Heart Nuclear DNA Fragments and the Specific-protein Interaction by AFM

bcl-2基因的转录调控

Transcription Regulation of bcl - 2 Gene

S/MAR既有一定的特征，又有多样性，研究认为它参与了DNA复制调控和转录调控等多种核内生化过程。

Some studies found that some S / MARs were associated with many biochemical processes such as the regulation of DNA replication and transcription .

IL-1β对正常和自发性高血压大鼠血管平滑肌细胞iNOS基因转录调控因子的影响

Effect of IL 1 β on the Transcript Control Factors of iNOS

首次探讨了干扰素α抑制肝癌细胞内VEGF及血管生成的转录调控机制。

Explore the mechanism of inhibitory effect of interferon alpha on VEGF transcription in HCC cell line .

在现有的多种组蛋白修饰中，组蛋白赖氨酸的甲基化实际上参与了所有的以染色质为基础的生物进程，包括转录调控和DNA损伤修复。

Among various histone modifications identified , histone lysine methylation functions in virtually all chromatin based biological processes including transcriptional regulation and DNA damage repair .

granzymeb基因转录调控机制的研究及perforin/granzymeb通路在实验性自身免疫性葡萄膜炎的致病机制中作用的研究

Transcriptional Regulation of Human Granzyme B Gene and the Role of Perforin / granzyme B Pathway in EAU Disease

目的：对在LPS、TNFα刺激下，人β防御素2基因5′端转录调控机制进行初步分析。

Objective : To identify the transcriptional regulation element in the promoter region of HBD 2 gene .

锌指蛋白作为主要的转录调控因子，在RNA的转录过程中发挥着非常重要的调控作用。

As the major transcriptional factors , the zinc finger proteins play very important role during the regulation of RNA transcription .

人CD34分化抗原转录调控序列的克隆与调控表达

Cloning and Regulating Expression of Human CD34 TRS

这些基因主要包括基础代谢有关基因，转运子基因，转录调控有关的基因，DNA复制及修复，细菌自溶酶以及甲基化酶基因等。

The functions of these differentially expressed genes were involved in basic metabolism , gene transcription regulation , transporter , DNA repair and replication , autolysin and methylation .

通常发生在基因转录调控区域（例如基因启动子区域）的DNA甲基化可导致基因转录失活，抑癌基因的表达沉默易导致肿瘤的发生发展。

Methylation in transcription regulatory regions can result in the inhibited expression of genes , and silence of tumor suppressor genes can lead to pathogenesis and progression of tumors .

GO分类表明，这些基因的功能主要为催化功能，核酸结合，蛋白结合以及转录调控功能，参与代谢过程，发育过程，生物过程的调控以及色素形成。

GO analysis showed their functions are mainly catalytic activity , nucleic acid binding , protein binding and transcription regulation , involved in metabolic process , development process , the regulation of biological process and pigmentation .

通过分析获得了猪ob启动子序列及其转录调控信息。

The transcriptional in form ation of the proximal promoter of ob was obtained .

BFL1/hA1是Bcl-2家族中分子结构、作用途径和转录调控研究得比较深入的一个分子。

BFL1 / hA1 is one of the Bcl-2 family members and is well studied on domain organization , functional pathway and transcription regulation .

植物雌激素α-玉米赤霉醇对HUVEC组织因子基因表达的转录调控作用

Transcription regulation on tissue factor gene expression in the HUVEC by phytoestrogen α - zearalanol

结果：发现受白蛋白增强子／启动子转录调控的IL－2和TNF基因在原位感染实验性肝癌可使肝癌逐渐缩小。

Results : It was found that the hepatoma regressed gradually following in situ transfer with IL-2 and TNF genes under transcriptional control of albumin enhancer / promoter .

人肿瘤多药耐药mdr-1基因的转录调控机制复杂。

Transcription of human mdr-1 gene is complex and highly regulated .

Sp1和Sp3介导的转录调控

Mechanism of Transcription Regulation Mediated by Sp1 and Sp3

TNFα诱导氧应激对人血管内皮细胞PDGF-B基因转录调控的影响及信号转导的探讨

Effects of TNF α - induced Oxidative Stress on Transcriptional Regulation of PDGF-B Gene and Its Signal Transduction in Endothelial Cell

缺氧诱导因子（HIF-1α，hypoxia-induciblefactor-1α）是介导细胞对缺氧微环境进行适应性反应的关键性转录调控因子。

Hypoxia-inducible factor-1 α( HIF-1 α) is a key transcriptional control factor of progressive adaptation reaction mediated cell hypoxia microenvironment .

本实验主要探讨p38MAPKs的四个成员在对iNOS转录调控中的作用以及可能机制，为深入理解p38MAPKs在炎症反应过程中的功能提供有力的依据。

Our experiments focus mainly on the role of four p38 subtypes in transcriptional regulation on iNOS gene and the possible mechanisms underlying .

c-Jun的活性调控发生在两个水平：转录调控和翻译调控。

At present , the regulation of c-Jun can occur at two main levels : transcriptional control and post-translational regulation .

这些结果显示，核内G-actin能够与P53协同作用，参与其对靶基因的转录调控。

In a conclusion , the nuclear G-actin can work in coordination with P53 in the regulation of gene transcription .

泛素&蛋白酶体途径参与小鼠SPEN家族MINT蛋白转录调控作用的研究

Ubiquitin Proteasome Pathway Participate in Spen Homolog MINT-mediated Transcription Regulation

基因转录调控作用是EGF的细胞核内作用之一，而序列特异的DNA结合蛋白质与基因转录的调控密切相关。

One of the important nuclear effects of EGF is regulation of gene transcription . The sequence-specific binding of proteins to DNA regulatory region is closely associated with regulation of gene transcription .