脱甲基
- 网络demethylation;MFOs
脱甲基-
以水杨醛为原料，经缩合、还原、酰化、脱甲基、溴化反应制得苯溴马隆，总收率40.6%。
Benzbromarone was synthesized from salicylaldehyde by condensation with chloroacetone , reduction , acylation , demethylation and bromination with 40.6 % overall yield .
-
结果在大鼠尿样中检测到7种I相代谢产物（如原药的脱氢、脱甲基、羟基化代谢物）及11种II相代谢产物（如甲基化轭合物和葡糖醛酸轭合物）。
Results At least seven phase I metabolites ( such as de-methyl , de-hydrogen and hydroxyl metabolites ) and eleven phase II metabolites ( such as glucuronide conjugates and methyl-conjugates ) were identified in rat urine .