甲氨蝶呤

甲氨蝶呤治疗类风湿关节炎对外周血淋巴细胞DNA的损伤

Low-dosed methotrexate treating rheumatoid arthritis causes peripheral lymphocytic DNA damage

与甲氨蝶呤加贴敷组比较△P0.05，有统计学意义。

Compared with methotrexate plus patching △ P 0.05 , statistically significant .

服用甲氨蝶呤患者比不用甲氨蝶呤的CAD事件可能性降低46%。

Patients on methotrexate had46 percent lower likelihood of CAD events than those not on methotrexate .

MRI引导聚焦超声开放家兔血脑屏障靶向甲氨蝶呤给药

Targeted Blood-Brain Barrier Disruption and Methotrexate Delivery to the Rabbit Brain via MRI-Guided Focused Ultrasound

HPLC法测定人血清中甲氨蝶呤的浓度

Determination of Methotrexate in Human Serum by HPLC

HPLC法测定甲氨蝶呤的血药浓度

Detection of blood methotrexate concentration with HPLC

淫羊藿苷逆转耐甲氨蝶呤肺癌A549细胞转移表型

Icariin reversed metastatic phenotype of methotrexate-resistant lung cancer A549 cells

小剂量甲氨蝶呤对RA患者血浆TNFαIL-6水平影响的研究

Influence of small dose methotrexate upon plasma TNF α and IL 6 levels of patients with rheumatoid arthritis

方法病人随机分为二组，甲氨蝶呤（MTX）组和帕夫林（TGP）组。

Methods By two groups-MTX and TGP .

目的探讨甲氨蝶呤（MTX）局部注射治疗子宫腺肌病的可行性。

Objective To study the effects of Methotrexate ( MTX ) local use on adenomyosis .

抗癌药物甲氨蝶呤在Nafion修饰电极上的伏安法研究

Voltammetry of Anti-Cancer Drug Methotrexate on Nafion Modified Electrode

结论鞘内联合注射甲氨蝶呤加地塞米松是治疗CNS、SLE的一种有效方法，值得进一步临床研究。

Conclusion IT with MTX plus DXM is a new promising method in treating CNS SLE and deserves further investigation .

目的了解甲氨蝶呤（MTX）的作用机制，探测其作用的遗传毒性靶器官。

Objective To explore the mechanism of methatrexate ( MTX ) further and the genotoxic target organs .

目的总结甲氨蝶呤（MTX）治疗输卵管妊娠后的生殖状态。

Objective To analyze the reproductive prognosis after treatment of tubal pregnancy with the systemic methotrexate ( MTX ) .

目的：研究MCA〔甲氨蝶呤、放线菌素D（更生霉素）、环磷酰胺〕/顺铂（DDP）方案治疗恶性滋养细胞肿瘤的疗效。

Purpose : To study the effectiveness of MAC / cisplatin ( DDP ) on patients with malignant trophoblastic tumor .

目的：建立一种快速、灵敏及检测范围大的高效液相色谱测定人血浆中甲氨蝶呤（MTX）浓度的方法。

Objective : To develop a HPLC method to determine the concentration of methofrexate ( MTX ) in human plasma .

摘要：目的探讨血药浓度监测在大剂量甲氨蝶呤（MTX）治疗血液系统肿瘤中的应用价值。

ABSTRACT : Objective To explore the clinical value of blood concentration monitoring during high-dose methotrexate ( MTX ) treatment .

用环孢菌素A联合短程甲氨蝶呤预防GVHD；

A combination of cyclosporine A ( CsA ) and methotrexate ( MTX ) was administered for GVHD prophylaxis .

目的观察风湿康冲剂加甲氨蝶呤（MTX）治疗类风湿关节炎（RA）的临床疗效。

Objective : To observe the therapeutic effect of Fengshikang Medicinal Granules combined with MTX in the treatment of rheumatoid arthritis ( RA ) .

目的：建立耐甲氨蝶呤（MTX）的人绒毛膜癌细胞株，并检测其生物学特性。

Objective : To establish a methotrexate ( MTX ) - resistant choriocarcinoma cell line and to determine its biologic characteristics .

目的：研究大剂量甲氨蝶呤（methotrexate，MTX）化疗的脑脊液药代动力学。

OBJECTIVE : To study the pharmacokinetics in cerebrospinal fluid ( CSF ) during high dose methotrexate ( HD-MTX ) chemotherapy .

结论：甲氨蝶呤可能对PIA大鼠血清IL-10和TNF-α均有明显抑制作用。

Conclusion MTX demonstrated prominent inhibition over serum expression of IL-10 and TNF - α in rat models with PIA .

聚丙交酯&乙交酯（PLGA）共聚和物组织工程支架的实验研究甲氨蝶呤聚乳酸或聚乙交酯丙交酯纳米粒的制备及其特性

Experimental Studies on Poly ( Lactide-co-glycolide ) Copolymer Scaffolds for Tissue Engineering ; Preparation and properties of methotrexate-loaded PLA or PLGA nanoparticles

目的探讨甲氨蝶呤联合氟美松鞘内注射治疗系统性红斑狼疮（SLE）中枢神经系统损害的效果。

Objective To evaluate the intrathecal injection of combining methotrexate ( MTX ) and dexamethasone ( DXM ) into lupus patients with central nervous system involvement .

目的探讨序贯应用甲氨蝶呤（MTX）与米非司酮保守治疗有胎心宫外孕的疗效和安全性。

Objective To investigate the effects and safety of sequential treatments with methotrexate and mifepristone for ectopic pregnancy with fetal cardiac activity .

环孢素A联合甲氨蝶呤预防方案可有效降低aGVHD的发生率，并减轻其严重程度；

CsA with MTX could effectively reduce the incidence of aGVHD and alleviate its severity .

目的：观察甲氨蝶呤（methotrexate，MTX）治疗中、重度银屑病的临床疗效和安全性。

Objective : To study the clinical effect of methotrexate ( MTX ) in the treatment of patients with moderate to severe psoriasis .

目的研究甲氨蝶呤（methotrexate，MTX）与长春新碱（vincristine，VCR）双载红细胞体外抗肿瘤效果。

Objective : To study the in vitro anti-tumor effect of methotrexate ( MTX ) and vincristine ( VCR ) - loaded erythrocytes .

结果甲氨蝶呤磁靶向脂质体的包封率大于60%，平均粒径为627.8nm，多分散系数为0.131，每毫升脂质体乳浊液包裹铁磁性物质为116.1μg，具有良好的稳定性。

RESULTS The encapsulation efficiency of the methotrexate reached 60 % , and the particle size of the liposome was 627.8 nm with the polydispersity index of 0.131 . The concentration of the encapsulated Fe_ 2 O_ 3 was 116.1 μ g.

目前治疗SLE的药物包括：非甾体抗炎药、糖皮质激素、抗疟药、免疫抑制剂（包括环磷酰胺、甲氨蝶呤、霉酚酸酯、来氟米特、硫唑嘌呤等）。

There are nonsteroidal antiinflammatory drugs , glucocorticoids , antimalarial agents , and immunosuppressive drugs , including cyclophosphamide , methotrexate and mycophenolate mofetil , azathioprine , which used to treat SLE .