抗代谢药

抗代谢药5－FU、FUDR、Ara－C、6－MP及MTX最好的耐受性和疗效是在傍晚或夜间睡眠期给药；

Antimetabolites ( 5-Fu , FUDR , Ara-C , 6-MP and MTX ) are better tolerated and most effective when administered in the evening or early in the daily sleep time .

核苷转运抑制剂潘生丁则能阻断核苷的这种抵消作用，从而增强抗代谢药的细胞毒性。

Dipyridamole ( DP ), a nucleoside transport inhibitor , can block the reversal effect , thus potentiating the cytotoxicity of antimetabolites to tumor cells .

由于与细胞正常代谢需要的化合物结构相似，抗代谢药成为干预细胞周期的一类药物。

This first anti-metabolite leads to a category of drugs that interfere with cell processes because they share structural similarities with a compound required in normal cell activity .

初步研究结果提示，细胞遗传学的异常、癌基因的存在，以及抗代谢药（羟基脲等）损伤染色体，产生异常的克隆，可能是发生第二肿瘤的原因。

In conclusion , the abnormal clone , induced by cytogenetics abnormity , oncogene and chromatosome damnification caused by antimetabolite yield , may be a reason of occurrence of second tumor .

烷化剂、抗代谢肿瘤药化疗引起的恶心、呕吐的治疗对策

Treatment Countermeasure of Nausea and Vomit Caused by Chemotherapy with Alkylating Agent and Antimetabolism Tumor Drug

培美曲塞（Alimta）是美国FDA2004年批准上市的抗代谢类抗肿瘤药。其作用机制是对叶酸代谢途径的多靶点阻断，因此，药物疗效高于其他抗叶酸类药物。

Pemetrexed ( Alimta ) is an antifolate drug approved by American FDA in 2004.As It can disrupt folate-dependent metabolic processes by multi-targets , the response rates are higher than other antifolate drugs available in clinical use .

抗代谢物，抗代谢药一种与基础代谢物非常相似的物质，因此能够干预包含代谢物的生理反应结论：该基因与脂质代谢和冠心病有关；

A substance that closely resembles an essential metabolite and therefore interferes with physiological reactions involving it . Conclusions : FDB was associate with hyperlipidemia and coronary heart disease .