扎来普隆

二类新药扎来普隆治疗失眠的II期临床研究

The Second Phase Clinical Trials of the Second Category Novel Hypnotic , Zaleplon for the Treatment of Insomnia

目的：建立测定人血浆中扎来普隆的高效液相色谱-大气压化学离子化-质谱（HPLC-APCI-MS）分析方法，研究扎来普隆口腔崩解片的人体相对生物利用度。

OBJECTIVE To establish an HPLC-APCI-MS method for the study of pharmacokinetics and bioavailability of zaleplon by comparing the difference of zaleplon in electrospray ionization and atmospheric pressure chemical ionization mode .

扎来普隆胶囊溶出度和含量测定

Determination of Content and Dissolution of Zaleplon Capsules by UV Spectrophotometry

扎来普隆胶囊治疗失眠症的多中心临床研究

Double blind and multi center clinical trial of Zaleplon capsule on insomnia

目的：研究扎来普隆胶囊剂的人体相对生物利用度。

AIM : To study the pharmacokinetics and relative bioavailability of zaleplon capsules .

国产扎来普隆治疗失眠症随机对照研究

Randomly controlled study on insomnia treated with domestic zaleplon

扎来普隆一般药理实验研究

Experimental study on general pharmacology of zaleplon

扎来普隆治疗失眠症的疗效及安全性：随机双盲对照研究

Effect and reliability of zaleplon on treatment of insomnia : a randomized , double blind , controll study

目前国内外临床上所用扎来普隆的剂型主要为片剂和胶囊剂等口服制剂。

The dosage forms of Zaleplon mainly used on domestic and aboard clinical practice is tablet and capsule .

单指标减分值比较，除扎来普隆组前4天的睡眠质量较佐匹克隆组低，有统计学意义以外，其余各指标差别无统计学意义。

Comparing the value reduction of single marker of SDRS between'two groups , no statistical significance , excluding the quality of sleep at the 4th day of treatment .

其中扎来普隆组24例（5～10mg/d），唑吡坦组24例（10mg/d），共治疗2周。

The 24 cases of total patients were treated with zaleplon ( 5 ~ 10 ? mg / d ) and the others were treated with zolpidem ( 10mg / d ) for 2 weeks .