尿酸生成

痛风症（gout）是由于体内嘌呤代谢紊乱导致尿酸生成过多的疾病，已被联合国列为21世纪二十大顽症之一。

Gout is due to the excessive of uric acid owing to the metabolism disorder of purine in vivo .

结果：迷迭香酸显著抑制尿酸生成和超氧离子引起的NBT显色，两种方法测得其IC50分别为56μg/ml和21μg/ml；

Results : Rosmarinic acid obviously inhibited the production of uric acid and superoxide anion-induced reaction in NBT assay , with their IC_ ( 50 ) being 56 μ g / ml and 21 μ g / ml , respectively .

体内尿酸生成超过肾脏排泄时血清尿酸会显著升高，造成高尿酸血症。

If the production of uric acid surpasses the level that excreted by kidney , the serum level of uric acid will increase and hyperuricemia will occur .

高尿酸血症是嘌呤代谢障碍性疾病，也是与代谢异常综合征和糖尿病密切相关性疾病之一，其主要原因是尿酸生成过多或肾脏排泄减少。

Hyperuricemia is a purine metabolic disorders are associated with the metabolic syndrome and diabetes , one closely related diseases , mainly because of too much or renal excretion of uric acid reduction .

芒果苷的初步结构修饰芒果苷，是从芒果叶以及知母提取出来的一种双苯吡酮类化合物，可通过抑制黄嘌呤氧化酶减少尿酸生成而发挥抗痛风活性作用。

The preliminary structural modifications of mangiferin Mangiferin , extracted from mango leaves and Anemarrhena , is a double benzene , pyridine ketone compound , it can reduce production of uric acid by inhibiting xanthine oxidase , play the role of anti-gout activity .

有大约25个油蚕突变的形成与尿酸的生成、运输和蓄积相关。

The formation of more than 25 oil silkworm mutants is thought to be associated with the synthesis , transport and accumulation of uric acid .