苯丁酸氮芥

采用紫外可见光谱滴定法测定了β环糊精（βCD）在10℃，不同pH值条件下包合苯丁酸氮芥（CHL）的稳定常数，探索了主客体分子间的作用机理。

UV-vis spectrophotometric titration was used to calculate the stability constants of an inclusion complex of β - cyclodextrins (β - CD ) with chlorambucil ( CHL ) in different pH buffer solutions at 10 ℃ .

目的探索苯丁酸氮芥（CHB）和环磷酰胺（CP）在体外是否通过烷化激活大鼠肝微粒体谷胱甘肽S-转移酶（mGST）。

AIM To study whether chlorambucil ( CHB ) and cyclophosphamide ( CP ) activate rat liver microsomal glutathione S-transferase ( mGST ) by alkylation .

考虑到疏水药物苯丁酸氮芥的靶标是DNA链，经苯丁酸氮芥修饰的阳离子聚合物既有利于基因转染，又可以增强药效。

Considering that the target of hydrophobic chlorambucil is DNA strands , the hyperbranched polycations are modified with chlorambucil for both gene transfection and drug delivery .

单克隆抗体&苯丁酸氮芥靶向治癌偶联物的研究

Studies on the Targeted Monoclonal Antibody-Chlorambucil Conjugate for the Treatment of Cancer

苯丁酸氮芥及环磷酰胺对大鼠肝微粒体谷胱甘肽S-转移酶的激活

Activation of rat liver microsomal glutathione S-transferase by chlorambucil and cyclophosphamide in vitro

结论：环磷酰胺、环孢素A、苯丁酸氮芥均能有效治疗肾病综合征且三者之间的治疗效果无明显差别。

The difference between the effective rate of cyclophosphamide , cyclosporin A , chlorambucil treatment group is not significant . Conclusions : Cyclophosphamide , cyclosporin A , chlorambucil are all effective in the treatment of nephrotic syndrome without significant difference .