胰岛素瘤

双期薄层动态增强CT在胰岛素瘤术前诊断中的价值

Value of Dual-phase Thin Thickness Dynamic Enhanced Muti-row Detector CT in the Preoperative Diagnosis of Pancreatic Insulinoma

胰岛素瘤是一种胰腺内分泌肿瘤，亦称B细胞瘤，发病率极低，易误诊，造成不可逆的精神、神经损害。

Objective Insulinoma is a insulin endocrine tumor , also called B cell tumor , the mortality was low , easy to distort and irreversible psychic and nerve harm .

优化CT扫描方案在胰岛素瘤术前定位诊断中的临床价值

Improved MSCT Scanning Protocol for Preoperative Localization and Diagnosis of Insulinoma

增强螺旋CT诊断胰岛素瘤

Contrast enhanced spiral CT for the detection of insulinoma

目的评价动态螺旋CT动脉造影在胰岛素瘤定位诊断中的价值。

Objective To evaluate the value of intra-arterial dynamic spiral CT on preoperative localization of insulinoma .

抑脂技术和动态增强MRI在胰岛素瘤诊断中的价值探讨

Value of fat suppression and dynamic contrast-enhanced MRI in the diagnosis of insulinoma

不同HIV蛋白酶抑制剂对鼠胰岛素瘤细胞功能的影响

Effects of various HIV protease inhibitors on function of rat insulinoma cells

胰岛素瘤术前CT定位诊断的回顾性分析

The analysis of localization diagnosis with insulinoma before surgery . Retrospective analysis of preoperative localization of insulinomas on CT

目的探讨胰岛素瘤的MRI表现及最佳检查序列。

Objective To discuss MRI features of insulinomas and to explore the optimal MRI scanning sequence .

胰岛素瘤的MRI诊断

MRI Diagnosis of Insulinomas

目的探讨增强螺旋CT（SCT）扫描对胰岛素瘤的诊断。

Objective To evaluate contrast enhanced spiral CT in the diagnosis of insulinoma .

结论MRI和DSA是胰岛素瘤术前定位诊断准确率高而有效的方法。

Conclusion MRI and DSA are effective imaging methods for preoperative localizing diagnosis of insulinoma .

结论动态增强MRI是胰岛素瘤术前定位诊断敏感而准确的方法。

Conclusion The results indicate that dynamic contrast-enhanced MRI is an sensitive and accurate method for the preoperative localization of insulinoma .

胰岛素瘤的MSCT诊断（附16例报告）

MSCT Diagnosis of Insulinoma ( a Report of 16 cases )

与手术后病理结果比较，动态增强MRI对胰岛素瘤术前定位诊断准确率为91.7%（11/12）。

The diagnostic accuracy of insulinoma by dynamic contrast-enhanced MRI was 91.7 % ( 11 / 12 ) as compared with histological study .

目的：评价CT、DSA、超声内镜检查及联合2种检查对胰岛素瘤术前定位诊断的价值。

Objective : To determine the value of CT , DSA , endoscopic ultra sonography ( EUS ), and a combined protocol for preoperative detection of insulinomas .

超声内窥镜检查（EUS）在胰岛素瘤定位诊断中的应用

Endoscopic ultrasonography for preoperative diagnosis and localization of insulinomas

结果：胰岛素瘤3例，非功能性胰岛细胞瘤19例，超声与CT对其定位诊断正确率分别为77.8%（14/18）、75%（9/12）。

Results : The accuracy rates to locate the islet cell tumor by ultrasonography and CT were 77.8 % ( 14 / 18 ) and 75 % ( 9 / 12 ) , respectively .

应用MTT方法检测抗人IA-2抗体对胰岛素瘤细胞的杀伤。

The cytotoxicity induced by anti-human IA-2 antibody was analyzed by MTT assay .

HIV-1蛋白酶抑制剂Nelfinavir降低大鼠胰岛素瘤INS-1细胞胰岛素释放

HIV-1 protease inhibitor nelfinavir decreases insulin secretion from rat insulinoma INS-1 cells

142%（1/7）胰岛素瘤有一个位点LOH。

Loss of one locus was observed in 14.2 % ( 1 / 7 ) of insulinoma .

目的探讨蛋白激酶B及其磷酸化在棕榈酸诱导的胰岛素瘤细胞MIN6凋亡中的作用。

Objective To investigate the effect of protein kinase B and its phosphorylation on the apoptosis of MIN6 induced by palmitate .

而与手术后病理结果比较，EUS对胰岛素瘤的诊断符合率为83.3%（5/6）；

The diagnostic accuracy of insulinoma by EUS was 83.3 % ( 5 / 6 ) as compared with histological study .

结果显示：胰岛素瘤及胰岛增生Ins均阳性，Ins阳性程度与临床症状的轻重无关。

The results showed that insulinomas and hyperplasia of pancreatic islet cell stained positively with lns . the intension of the Ins had no relationship with the clinical symptoms .

目的探讨葡萄糖、肿瘤坏死因子（TNF）-α、干扰素（IFN）-γ对胰岛细胞自身抗原胰岛素瘤相关蛋白（IA）-2表达水平及胰岛素分泌水平的影响。

Objective To explore the effect of glucose and cytokine ( TNF - α, IFN - γ) to the level of insulinoma associated protein-2 ( IA-2 ) mRNA and insulin concentration .

结果①17例共22个胰岛素瘤作了手术切除（其中包括一例多发性胰岛素瘤），SCT探测胰岛素瘤敏感性为90.9%。

Results There were 22 insulinomas of 17 patients . The sensitivity of enhanced Spiral CT for the detection of insulinoma was 90.9 % .

目的研究酒精能否诱导小鼠胰岛素瘤细胞（NIT-1）凋亡，初步探讨凋亡发生机制。

Objective To decide whether ethanol induce apoptosis in mouse insulinoma cells ( NIT-1 ) and the potential mechanism involved .

结论：EUS对胰岛素瘤的诊断有重要意义，联合EUS及DSA检查是检查胰岛素瘤的最有效手段。

Conclusion : EUS is important to detect insulinomas , and the most effective method for revealing insulinomas is a combined imaging protocol that consists of both EUS and DSA .

结果16例患者，手术和病理证实孤立性胰岛素瘤12例和胰岛细胞增生1例，除1例胰岛素瘤外，ASVS对肿瘤均做出了准确定位；

Except one insulinoma , ASVS allowed accurate localization of the tumor .

结论典型的Whipple三联症有助于胰岛素瘤的早期诊断，术中超声检查能有效定位，合理手术是治愈胰岛素瘤的关键。

Conclusion The typical Whipple 's triad symptoms will help to early diagnosis , the BUS during operative is the choice of localization , effective operation remains the main methods to cure insulinoma .