盐酸丁螺环酮

盐酸丁螺环酮对脑卒中后情感障碍及神经功能的影响

Effects of buspirone hydrochloride on post-stroke affective disorder and neural function

盐酸丁螺环酮口腔粘附片的制备及释药机理初步研究

Preparation of buspirone hydrochloride buccal adhesive tablet and Study on its drug release mechanism

建立了血浆样品中盐酸丁螺环酮的气相色谱质谱（GCMS）联用的定量分析方法。

A method for the quantitative determination of buspirone in plasma was developed by means of GC-MS with selected ion and qualifier ion monitoring .

方法采用离体动物口腔粘膜的体外渗透试验方法，比较盐酸丁螺环酮对家兔、豚鼠、猪、羊和牛的口腔粘膜渗透性，考察药物浓度及溶液pH值的影响。

METHODS The in vitro penetration model was designed to investigate drug buccal mucosa permeability , and the influence factors ( different animal oral mucosa , such as rabbit , guinea pig , pig , sheep and cow , drug concentrations and solution pH values ) were measured .

结果表明BPR-HPMC缓释片具备了缓释制剂的某些特点，比如盐酸丁螺环酮体外持续释放达24h，该缓释片存在的缺点是在2h之前药物释放太快。

This matrix system ( BPR-HPMC extended release Tablets , BPR-HPMC ) shows some characterization of extended-release , for example , Buspirone Hydrochloride release in vitro 24 for hours .

盐酸丁螺环酮对动物口腔粘膜的渗透性及其机理

Permeation of buspirone hydrochloride across animal buccal mucosa and its mechanism

盐酸丁螺环酮临床药代动力学及生物利用度研究

Studies on pharmacokinetics and bioavailability of buspirone hydrochloride in human

盐酸丁螺环酮贴剂体内透皮吸收试验及血浆样品测定

Transdermal percutaneous absorption test of buspirone hydrochloride paste in vivo and determination of plasma samples

目的：评价盐酸丁螺环酮治疗脑卒中后情感障碍及其对神经功能的影响。

AIM : To evaluate the effects of buspirone hydrochloride on post stroke affective disorder and neural function .