瑞舒伐他汀钙

瑞舒伐他汀钙可有效地降低动脉粥样硬化小鼠的血和主动脉中IFN-γ含量以及血清抵抗素含量，显著抑制炎症反应，抑制粥样斑块进展。

The rosuvastatin calcium could significantly decrease the levels of IFN - γ in serum and the thoracoabdominal aorta and decrease the levels of resistin in serum , inhibit inflammatory and inhibit the progression of atherosclerosis .

病理结果显示主动脉内皮损害模型组明显较对照组严重，瑞舒伐他汀钙高、中、低剂量组血管内皮损害有不同程度减轻，呈剂量依赖性，以高剂量组损害最轻。

The pathological results showed the damage of aortic endothelium in model group was significantly more severe than that in control group , and was dose dependent in rosuvastatin calcium groups , and it was the lightest in high dose group .

结果：瑞舒伐他汀钙高、中、低剂量组血清C反应蛋白、白细胞介素-6、肿瘤坏死因子-α及血尿酸水平均明显低于模型组（P0.01）。

Results : The serum C-reactive protein , interleukin-6 , tumor necrosis factor alpha and serum uric acid levels in rosuvastatin calcium groups were lower than those in the model groups ( P 0.01 ) .

因此，瑞舒伐他汀钙可在缺血性脑卒中临床二级预防中广泛应用。

So , Rosuvastatin can be used generally in the secondary prevention of cerebral ischemic stroke .