多极纺锤体

异常中心体可产生多极纺锤体，使染色体错误分离及分配不平衡，介导染色体不稳定性（CIN）和非整倍体的形成。

Abnormal centrosome can cause multipolar spindle formation , chromosome mis-segregation , and unequal distribution , and finally leads to cancers .

纺锤体微管的形态发生了改变，出现了两个纺锤体、巨大纺锤体和多极纺锤体等异常结构。

Abnormal spindles such as two spindles , one large spindle and multi-polar spindles occurred .

细胞骨架破坏和具有多极纺锤体的异常有丝分裂，推测是多核巨细胞不断产生的根源。

There was cytoskeletal breakdown and abnormal mitosis characteristic of multiple spindle poles , largely resulting in accumulation of giant multinuclear cells .

中心体复制周期的异常会导致单极或多极纺锤体的形成，后者一直被认为是染色体不稳定和肿瘤发生的原因。

Aberrations in the centrosome duplication cycle result in the formation of monopolar or multipolar spindles , and it has been long proposed that such aberrations may cause aneuploidy and contribute to cancer development .