化学致癌剂

电离辐射及化学致癌剂（BP）诱发鼠胚培养细胞姊妹染色单体互换及染色体畸变的研究

Sister chromatid exchanges ( sce ) and chromosomal aberrations of cultured cells of mouse embryo induced by ionizing radiation and chemical carcinogen

目的：探讨蛙皮素在化学致癌剂N鄄甲基鄄N'鄄硝基鄄N鄄亚硝基胍（MNNG）诱发人胃黏膜上皮永生细胞系GES鄄1癌变过程中的作用。

Aims : To investigate the effects of bombesin on the malignant transformation of immortalized human gastric epithelial cell line GES-1 induced by chemical carcinogen N-methyl-N ′ - nitro-N-nitrosoguanidine ( MNNG ) .

结论：蛙皮素可与化学致癌剂协同促进正常上皮细胞癌变，其机制可能与cyClinD1的过表达有关。

Conclusions : Bombesin seems to exert a synergistic effect with chemical carcinogen in promoting malignant transformation of normal epithelial cells , which may be related to the increased cyclin D1 expression .

鼻咽癌患者外周淋巴细胞经紫外线或化学致癌剂N-甲基-N'-硝基-N-亚硝基胍（MNNG）处理后，其非程序DNA合成（UDS）值比健康人的为低；

Using UV or MNNG as inducing agents , the UDS values of peripheral lymphocytes from patients with nasopharyngeal carcinoma ( NPC ) were found to be lower than that from normal healthy subjects .

方法：1.取体重150～200g雄性近交系F334大鼠150只，随机分为实验组和对照组，利用化学致癌剂二乙基亚硝胺（DEN）建立起近交系F334大鼠肝癌模型。

150 male inbred rats ( 75-100Kg ) are divided into experimental group and control group randomly , the rat of liver cancer model is established by low dose DEN . 2 .

结论：化学致癌剂诱发实验性早期肝癌过程中，IL6可能是激活HGF的细胞因子，HGF以自分泌机制发挥促肝细胞增殖的效用。

Conclusions During rats are induced into early hepatocellular carcinomas by chemical carcinogen , the gene of HGF may be actived by a cytokine , IL 6 . An autocrine mechanism was suggested in HGF for the proliferation of hepatocytes .

化学致癌剂和化学致癌机理的研究状况

Situation for Researches on Chemical Carcinogens and on Mechanism of Chemical Carcinogenesis

化学致癌剂诱发大鼠肝癌过程中凝集素受体的表达

The expression of lectin receptors during hepatocarcinogenesis induced by chemical carcinogen in rats

本文综述了化学致癌剂及化学致癌机理的近代研究状况。

The recent situation for the researches on chemical carcinogens and on the mechanism of chemical carcinogenesis is reviewed in this paper .

近来作者提出了化学致癌剂结构与活性关系的定量分子轨道模型&双区理论。

Recently , the author of this paper has suggested a quantitative molecular orbital model & " di-regions theory " for the chemical structure-carcinogenic activity relationship .

结论上述结果提示Kupfer细胞能够降低化学致癌剂对肝细胞的毒性损伤，从而在一定程度上对肝细胞的癌变过程可能具有抑制作用。

Conclusions The results suggest that Kupffer cells can reduce hepatotoxicity induced by chemical carcinogen , and Kupffer cells may play an inhibitory effect on the process of hepatocarcinogenesis .

结论：卵圆细胞是宿主受化学致癌剂作用后发生肝癌的始动细胞，与肝癌的发生有着密切的联系。

Conclusion : The oval cells might be the initiated cells of liver carcinoma of host rats fed by chemical carcinogen and have a close relationship with histogenesis of liver carcinoma .