丙磺舒

氨苄西林丙磺舒胶囊的HPLC测定

Determination of Ampicillin and Probenecid Capsules by HPLC

6种利尿剂及丙磺舒的提取甲基化的GC／MSD研究

A Study on the Extractive Methylation of 6 Diuretics and Probenecid Using GC / MSD

丙磺舒对大鼠血浆环磷酸腺苷（cAMP）代谢清除率和产生速率的影响

Effect of probenecid on metabolic clearance rate and production rate of plasma cyclic adenosine 3 ' , 5 ' - monophosphate ( cAMP ) in rats

多药耐药相关蛋白（MRP）载体在药物的体内处置过程中发挥了重要的作用，丙磺舒对MRP有较好的抑制作用。

Multidrug resistance-associated protein ( MRP ) plays an important role in the pharmacokinetics of a drug in the body . However , the function of MRP can be affected by probenecid .

以pH6.8磷酸盐缓冲溶液250ml为溶剂，转速100r/min，30min取样，采用高效液相色谱法同时测定氨苄西林和丙磺舒的溶出量。

Phosphate buffer ( pH6.8 ) was used as the solvent , and the paddle rotated at 100r / min , The content of ampicillin and probenecid was determined simultaneously by HPLC .

在难治性癫痫大鼠模型中，托吡酯以及托吡酯和丙磺舒联合治疗可以对海马神经元起保护作用，可以使GFAP表达减弱，两治疗组间表达GFAP星形胶质细胞的数目和积分光密度无统计学差异。

In the rat model of intractable epilepsy , topiramate and topiramate plus probenecid treatment can both protect hippocampal neurons , weakening GFAP expression . However , there is no statistical difference between the numbers of positive cells and integrated optical density in the two treatment groups . 3 .

氨苄青霉素/丙磺舒胶囊的临床疗效与安全性研究

A Study on the Efficacy and Safety of Ampicillin / Probenecid

氨苄西林／丙磺舒胶囊的人体生物等效性研究

Bioequiavailability of Ampicillin and Probenecid Capsules in Human Body

注射用氨苄西林钠/丙磺舒钠体内药效学研究

Study on Pharmacodynamics of Ampicillin Sodium and Probenecid Sodium for Injection in Vivo

丙磺舒可显著地抑制吡哌酸的肾脏排泄，降低其体内清除率，提高血药水平。

Probenicid could remarkably increase the half-life and AUC of pipemidic acid by reducing its clearance .

目的比较两种氨苄西林丙磺舒胶囊的药代动力学参数及人体生物等效性。

Objective To evaluate the pharmacokinetic properties and bioequivalence of two different capsules of ampicillin probenecid capsules .

【方法】将90例湿热阻络型痛风患者随机分为治疗组（30例）和对照组（60例），其中对照组又分为别嘌呤组（22例）和丙磺舒组（38例）。

Method : 90 patients with the type of Damp-heat stagnates were distributed to treating group ( 30 ) and control group ( 60 ) randomly .

采用随机对照多中心临床研究，使用氨苄青霉素/丙磺舒胶囊治疗急性细菌性感染患者104例。

In this multicenter clinical trial , the authors studied the effect of ampicillin / probenecid on acute bacterial infection . A total of 154 patients were recruited .

目的：比较在大鼠中丙磺舒、甲氨蝶呤、地高辛、维拉帕米等不同药物转运蛋白底物对双环铂肾排泄的影响。

Aim : To compare the effects of the drug transporter substrates such as probenecid , methotrexate , digoxin and verapamil on renal excretion of dicycloplatin in rats .

丙磺舒被推荐用于治疗痛风及痛风关节炎，及在强化抗感染治疗时增加并延长青霉素类及头孢菌素类的血浆浓度。

Benemid is recommended for the treatment of gout and gouty arthritis , and to increase and prolong the plasma concentration of penicillins and cephalosporins during anti-infective therapy .

目的为建立发现和评价促尿酸排泄药物作用的离体模型，采用离体大鼠肾脏灌流技术，观察尿酸在离体肾脏中排泄特点和丙磺舒对尿酸排泄影响。

Aim To establish a in vitro model for discovery and evaluation of uricosuric drug , we established a reliable rat isolated perfused kidney ( IPK ) preparation and observed urate excretion characterization in absence or presence of probenecid in perfusate by IPK .