丙二酸二乙酯

氟阴离子在有机合成中的应用Ⅰ.无水氟化钾催化丙二酸二乙酯与苯甲醛的Knoevenagel缩合反应

Application of Fluoride Anion in Organic Syntheses ⅰ . Knoevenagel Reaction of Diethyl Malonate with Benzaldehyde Catalyzed by Anhydrous Potassium Fluoride

丙二酸二乙酯（DiethylMalonate，DEM），俗称胡萝卜酸乙酯，是一种重要的精细化工有机原料，被广泛应用于聚酯、医药、染料及香料等工业。

Diethyl malonate ( DEM ), as is often called Carrot acid ethyl ester , is an important fine chemical material , which is widely used in polyester , pharmaceutical , dyestuff and perfume industries .

根据此结构关系可以推定此加成反应是由丙二酸二乙酯形成的自由基[·CH（CO2C2H5）2]对烯烃的亲电子性自由基加成反应。

It indicates that this addition reaction is an electrophilic free-radical addition of the malonic ester radical , CH ( COOC_2H_5 ) _2 , to the alkene molecules .

实验部分主要包括三部分：（1）来源于天然产物酒石酸和乳酸的CIL的合成，以及其作为手性溶剂在查耳酮和丙二酸二乙酯的不对称Michael加成中的应用。

While in the experiment section , we described three parts : ( 1 ) synthesis of new chiral ionic liquids from natural acids and their applications in enantioselective Michael addition .

以丙二酸二乙酯和盐酸胍为起始原料，经环合、亚硝化、还原、氯化、水解得到2-氨基4,6-二氯-5-甲酰氨基嘧啶，总收率20%，其结构经1HNMR和IR表征。

N - ( 2-amino-4,6-dichloro-5-pyrimidinyl ) formamide was synthesized from diethyl malonate and guanidine hydrochloride via cyclization , nitrosation , reduction , chloridization , hydrolysis with an overall yield of 20 % . The structure was characterized by 1H NMR and IR .

当催化剂用量以F-计为0.03mol，反应原料丙二酸二乙酯与丙稀腈之比为3：1，反应时间为2h，加成反应的转化率最高。

When the amount of catalyst is 0.03 mol ( based on F - ) and the molar ratio of acrylon to malonic ester is 1:3 , the yield of Michael addition reaction was over 88 % after 3 hours .

在CH2Cl2中，以丙二酸二乙酯为配体，与TiCl4-Al组成的诱导体系对一些芳香醛的片呐醇偶联反应有好的化学选择性和非对映立体选择性。

Using ethyl acetoacetate as an ligand , the pinacol coupling of some aromatic aldehydes mediated by TiCl_4-Al in CH_2Cl_2 had good chemoselectivity and diastereoselectivity .

在无水乙醇中，以六氢吡啶为催化剂，通过水杨醛与丙二酸二乙酯的Knoevenagel缩合反应合成了香豆素-3-羧酸乙酯，再经水解、酸化得到香豆素-3-羧酸。

Ethyl coumarin-3-carboxylate was synthesized from salicylaldehyde and diethyl malonate in absolute alcohol by Knoevenagel condensation reaction using hexahydropyridine as the catalyst . Hydrolysis of the reaction product with sodium hydroxide gave coumarin-3-carboxylic acid .

微波辐射硫酸铁催化合成丙二酸二乙酯的研究

Synthesis of Diethyl Malonate Catalyzed by Ferric Sulfate under Microwave Irradiation

微波辐射相转移催化丙二酸二乙酯丁基化反应研究

Butylation of Diethyl Malonate Catalyzed by Phase-transfer Catalyst and Microwave Irradiation

固-液相转移催化羰基化合成丙二酸二乙酯

Synthesis of Diethyl Malonate by Carbonylation under Solid-Liquid Phase Transfer Conditions

丙二酸二乙酯萃取电子废弃物中的金

The extraction of gold from electronic scrap with diethyl malonate

丙二酸二乙酯相转移烷基化反应的协同作用

Co-Catalytic Effects in Phase-transfer Catalyzed Alkylation Reaction of Diethyl Malonate

相转移催化合成丁基丙二酸二乙酯研究

Study on the phase transfer catalyzed synthesis of diethyl butylmalonate

方法：以丙二酸二乙酯为原料，途经加成、保护、脱乙氧羰基和还原等4步反应合成（2）。

METHODS : The compound was synthesized from diethyl malonate in 4 steps .

羰基钴催化羰化合成丙二酸二乙酯

Carbonylation of Ethyl Chloroacetate Catalyzed by Cobalt Carbonyl

以溴乙烷和丙二酸二乙酯为原料合成2-乙基丙二酸二乙酯，收率为90.4%。

2-ethyl diethyl malonate was synthesized from diethyl malonate and bromoethane in 90.4 % yield .

羰基钴催化剂的制备及其催化羰基化合成丙二酸二乙酯

The Preparation of Cobalt Carbonys Catalyst and Its Catalyzed Carbonylation for Synthesis of Diethyl Malonates

将所得的苯乙基丙二酸二乙酯皂化继而酸化，最后得到了苯乙基丙二酸。

Finally , phenylethyl malonic acid was obtained by acidification from saponification of the ester .

丙二酸二乙酯和芳烃在三乙酸锰和磷酸作用下也能发生同样的反应。

The reaction of malonic ester with aro-matics can also be carried out by above reagents .

LC-GC/FTIR联用方法分析丙二酸二乙酯中的污染物

Analysis of the pollutant in purified diethyl malonate by on line LG gc / ftir method

研究了采用萃取剂丙二酸二乙酯回收电子废弃物中金的方法。

With diethyl malonate as the extractant , the condition of extracting gold the electronic scrap was studied .

分子结构与化学活性间的定量关系Ⅱ.烯类与丙二酸二乙酯的加成反应

A quantitative relationship between molecular structure and chemical reactivity ⅱ . the addition reaction of alkenes and diethyl malonate

用取代的氯苄衍生物以及乙酰氨基丙二酸二乙酯为原料，合成了邻位、对位、间位甲基取代苯基丙氨酸。

By using substituted benzyl chloride and acetyl acetamidomalonate as starting material , m - , p-and o-methylphenylalanines have been synthesized .

目标产品纯度98%，产率高达96%（以丙二酸二乙酯计）。

The purity of final product is 98 % with yield up to 96 % ( in terms of diethyl malonate ) .

简述了丙二酸二乙酯的生产和合成技术，详细介绍了它在有机合成中的广泛用途。

Sketch diethyl malonate production and synthetic technology of ester , introduce it ′ s extensive use in the organic synthesis in detail .

根据缩合原理，研究并提出了“克兰逊”催化缩合法，通过特性触煤合成了乙氧基甲叉基丙二酸二乙酯产品，提高了产品质量及回收率。

Through the peculiarity contact-coat , composes the ethoxy methylene propane dioic acid dio-ethylest which improves the quality and yield of the product .

实验以水杨醛、丙二酸二乙酯为原料，乙醇钠为催化剂催化合成香豆素-3-羧酸乙酯，再经皂化、酸解环合合成香豆素-3-羧酸。

Synthesis of coumarin-3-carboxylic acid through sodium ethoxide catalyzed synthesis of coumarin-3-carboxylic acid ethyl ester , followed by saponification , acidolysis cyclization was studied .

在我们的合成方法中，先从2-苯乙醇开始合成了2-苯乙基氯，再用丙二酸二乙酯的烯醇盐离子进行亲核取代。

First we synthesized the 2-phenylethyl chloride from 2-phenylethyl alcohol . Then it was substituted by enolate anion of diethyl malonate and converted to ester .

本文报道在碳酸钾存在下，丙二酸二乙酯、氰乙酸乙酯的固液相烃基化反应。

The alkylation of diethyl malonate and ethyl cyanoacetate using powdered potassium carbonate asa base in the absence of solvent and other catalyst is studied .