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However , once the microglia were sustained activated , they would produce some cytotoxic factors , like superoxide , tumour necrosis factor-a ( TNFa ) and nitric oxide ( NO ) and confer damage to neurons .

但是这些细胞一旦持续过度激活，就会产生一些细胞毒性物质，像过氧化物、肿瘤坏死因子、一氧化氮等，从而对神经元造成损伤。

[ Objective ] In order to research on the effection of moderate hypothermia on cerebrospinal fluid tumor necrosis factor a ( TNFa ), interleukin-6 ( IL-6 ) and interleukin-8 ( IL-8 ) levels and therapy mechanism after severe traumatic brain injury in humans .

[目的]研究亚低温治疗对重型颅脑创伤患者脑脊液中TNFα、IL-6及IL-8水平的影响，并探讨亚低温治疗的机理。

Objective : To observe the effects of cigarette smoke extract ( CSE ) on the activation of nuclear factor-KB ( NF-kB ) and levels of tumor necrosis factor - α ( TNFa ) in human alveolar epithelial cell line ( A549 ) .

目的：观察香烟烟雾提取物（CSE）对肺泡Ⅱ型上皮细胞（A549）活性、核因子-κB（NF-κB）的诱导及对肿瘤坏死因子（TNFα）水平的影响；