tetramer

MHC peptide tetramer is a sensitive method to evaluate antigen specific CTL .

MHC-肽四聚体技术是近年来建立的检测特异性CTL的有效方法。

Construction of a BF2 / Peptide Tetramer and Its Application on the Detection of Specific T Cell

BF2/肽四聚体的构建及其在特异性T细胞检测上的应用

Quantitation of antigen specific T lymphocytes in peripheral blood of patients with primary biliary cirrhosis using tetramer technology

四聚体技术检测原发性胆汁性肝硬化患者血循环中抗原特异性T细胞

Detection of HBV specific cytotoxic lymphocytes responses in severe hepatitis B patients using MHC-peptide tetramer flow cytometry

重型肝炎患者乙型肝炎病毒特异性细胞毒性T淋巴细胞应答功能研究

Application of MHC-peptide Tetramer Technology in Epitope Identification

MHC-肽四聚体技术在CTL表位鉴定中的应用

In order to increase the stability of hemoglobin tetramer , relationship of hemoglobin 's structure and function were studied with computer modeling approach .

为了研究提高血红蛋白四聚体的稳定性，利用计算机同源模建、分子间氢键形成及表观静电势理论，探讨血红蛋白及相应突变体的结构与功能关系。

Construction of recombinant vector MHC - ⅰ - fluorescin tetramer and its eukaryotic expression

MHC-Ⅰ荧光四聚体载体的构建及其真核表达

Flow cytometry analysis indicated that the tetramer could bind to specific CTL from HLA-A11 + donor .

流式细胞仪分析显示所制备的四聚体可与HLA-A11+供者的抗原特异性CTL结合。

Biological activity of tetramer of bispecific single-chain antibody against human prostate-specific antigen and CD3 molecule

抗前列腺特异抗原/抗CD3双特异性单链抗体四聚体的活性研究

Preparation and identification of HBc-HLA-A ~ 1101 - β _2m complex monomer and tetramer

HBc-HLA-A~1101-β2m复合物单体及其四聚体的制备和鉴定

Peptide-MHC tetramer is the key technology of Immunology and Clinical diagnosis , and has been widely used in immunology research and immunological disease clinical research .

MHC-肽四聚体（Peptide-MHCtetramer）技术是免疫学和临床诊断中重要的技术，广泛应用于免疫学研究及免疫性疾病临床研究。

Advance in MHC-peptide tetramer technology

MHC-肽四聚体技术研究进展

The high benzyl methyl silicone oil could be obtained through polymerization of two benzyl mono - mers and D_4 cyclic tetramer .

用2种苯基单体和D4环体聚合，就可得到高苯基甲基硅油。

Preparing of the single-chain MHC-peptide complex tetramer

可溶性单链MHC-肽四聚体的构建研究

The Effects of Substrates and Inhibitor on the Submolecular Structure of Acetylcholinesterase Tetramer Incorporated in a Mica-supported Artificial Phospholipid Membrane

底物及抑制剂对重组在人工磷脂膜上的乙酰胆碱酯酶四聚体亚分子结构的影响

AIM : To study the biological activity of tetramer of bispecific single-chain antibody against human prostate-specific antigen ( PSA ) and CD3 molecule .

目的：研究抗前列腺特异抗原（PSA）/抗CD3双特异性单链抗体四聚体的生物活性。

Specific CTL responses were demonstrated by H 2K b OVA tetramer staining and cytotoxicity assay . Extracelluar IFN γ was also quantitatively analyzed .

应用H2Kb四聚体对特异性CTL检测结果与经典的细胞毒试验一致，同时对胞外IFNγ进行了定量检测。

All these results indicated that high quality of recombinant protein of BF2-BSP was obtained , which will be contributed to the construction of chicken MHC peptide tetramer .

实验获得了高纯度的在体外构建鸡MHC-肽四聚体所需的重组蛋白BF2-BSP。

The experimental results showed that Rhus Laccase polymerized the guaiacol to various low-molecular-weight polymers , two of which were identified to be tetramer and pentamer .

结果表明：漆树酶能使愈创木酚聚合为低分子聚合物，其中2种产物经鉴定为愈创木酚的四聚体和五聚体。

In recent years , MHC-peptide tetramer technology has been developed to directly ex vivo visualize antigen-specific T cells efficiently , and becomes the critical approach in studying T-cell immune responses .

MHC-肽四聚体技术是直接检测抗原特异性T细胞的有效而特异的方法，成为目前研究T细胞免疫应答的重要技术之一。

The results show that the zirconium atom exist as tetramer in sol and the nano zirconia is the product of deprotonation and polymerization of the tetramer .

结果表明，锆原子在胶体中是以氢氧化锆四聚物的形式存在的，纳米氧化锆是四聚物脱去质子进一步缩聚的结果。

The purpose of this review is to describe the rationale and method of tetramer technology , then to focus on the use of tetramer technology to study virus infection , anti-tumor actions and autoimmune disease .

本文就MHC-肽四聚体技术的基本原理、制备方法，以及在病毒感染、肿瘤、自身免疫性疾病等研究领域的应用进展作一综述。

CONCLUSION : The optimized tetramer staining condition can increase the specificity of tetramer staining and decrease unspecific binding , therefore it is applicable for phenotyping and functional analysis of antigen-specific CTL .

结论：通过对染色条件进行优化可明显提高四聚体染色的特异性，降低非特异性结合，优化的四聚体染色法能用于抗原特异性CTL的表型和功能分析。

Previously used methods for detecting specific CTL are usually indirect . In recent years , tetramer technology has been developed to directly visualize antigen-specific CTL efficiently , and become the critical approach in studying T cell immune responses .

而过去检测CTL的方法都是间接的，最近发展起来的四聚体技术则是直接检测抗原特异性CTL的有效而特异的方法，成为目前研究T细胞免疫应答的关键技术。

The octamer formation in vivo is related to cell growth process . During the log-phase of cell growth , the specific activity of nitrogenase is increasing , and the tetramer is the major form of molybdenum-iron protein .

在细胞生长过程中，胞内钼铁蛋白两种聚合体的相对含量出现规律性变化：在对数期，细胞固氮酶比活力成上升趋势，而钼铁蛋白主要以高活力的四聚体形式存在；

E. the acid volume of the catalyst increased , the conversion for isobutene and the selectivity for trimer increased also , while the selectivity for dimer decreased , and the selectivity for tetramer was almost unchanged .

增加时，即催化剂的酸量增加时，异丁烯的转化率和三聚物的选择性也增加，但二聚物的选择性降低，四聚物的选择性则几乎没有变化。

Conclusion HLA-peptides tetramer staining flow cytometry is a direct exvivo method to detect the lever of circulating HBV specific CD8 + cells which reflects the response of CTL and relates to clinical consequence in hepatitis B patients .

结论HLA肽四聚体流式细胞技术能在体外直接检测HBV特异性的CD8+T细胞数量，其水平一定程度上反映了特异性CTL应答状况，且与乙肝的不同临床转归有关。

As a dehydrogenase , GDH exists wildly in the animals , plants and microorganism . The enzyme exists in the form of tetramer or hexamer and plays a very important role in the metabolism of carbon and ammonia .

作为一种脱氢酶，它广泛的存在于各种动植物以及微生物体内，常以四聚体或六聚体的形式存在，在生物体的碳、氮代谢中起着非常重要的作用。

We suggest that , the octamer of molybdenum-iron protein is a possible metablite in regulation of nitrogenase activity , the conversion from the tetramer to octamer will cause the decrease of nitrogenase specific activity in vivo .

我们推断，生长过程中胞内钼铁蛋白聚合态的变化可能是调节固氮酶活力的一种方式。

260 protein was purified to homogeneity in a two-step procedure of Ni2 + chelating and size exclusion chromatography . The purified protein exists in two forms , a dimer form about 46 ku with yellow color and a tetramer form without apparent color .

260蛋白通过Ni2+亲和柱和分子筛两步法纯化，并发现纯化后的蛋白以两种形式存在，二聚体（约46ku）和四聚体，前者呈亮黄色，后者无色。