systemic toxicity

Investigation on effects of different administration way on acute systemic toxicity

评价生物材料不同给予方法致急性全身毒性作用的实验初探

Results : No animal died and had systemic toxicity reacts after the medicine was given .

结果给药后，动物无死亡和全身毒性反应。

Targeted intrapulmonary delivery of drugs may reduce systemic toxicity and improve treatment efficacy .

肺内定向给药可减少药物的系统毒性，提高疗效。

Analysis of Systemic Toxicity Resulted from Local Anesthetics in Tonsillectomy

扁桃体手术局麻药中毒的研究

The short term systemic toxicity test and hemolytic activity test of colored alumina-glass composite

有色氧化铝玻璃复合体溶血试验和短期全身毒性试验

Therapeutic effect of propofol on bupivacaine-induced systemic toxicity in rats

丙泊酚对布比卡因中枢及心脏毒性的治疗作用

Therefore , these findings were not considered to be of relevance for assessment of systemic toxicity .

所以，这些成果不视为与全身性毒性的评估有关。

Rescue and prevention of serious systemic toxicity following local anesthesia to mucous membranes of tetracaine

地卡因粘膜表面麻醉致严重全身毒性反应的救治与预防

In addition , intravesical IFN-a produces only minimal local and systemic toxicity .

此外，IFN的局部和全身毒性较小。因此，也引起了人们的高度重视。

Previous reports indicated that enantiomeric levobupivacaine has reduced systemic toxicity in central nervous and cardiovascular systems .

先前的研究指出左旋普宁卡因具有较低之中枢神经系统及心血管系统之毒性。

Methods The biocompatibility was evaluated through the experiments including acute systemic toxicity test , pyrogen , intracutaneous test .

方法：用小鼠和白化兔，通过急性毒性实验、热原实验、皮内实验进行生物相容性检验。

Developmental neurotoxicity of chlorpyrifos at subthreshold dose of overt systemic toxicity

亚中毒阈剂量毒死蜱的神经发育毒性

⑶ In acute systemic toxicity test , the mice in the negative control group and experimental group were generally in good condition and without weight loss .

⑶急性全身毒性试验，术后实验组和阴性对照组各只小鼠一般情况良好，无体重减轻，阳性对照组体重明显下降。

Objective To study the method of inhaling isotretinoin with sufficient drug to the target cells for efficacy while avoiding systemic toxicity .

目的探讨吸入异维甲酸能够针对靶细胞发挥足够药效的方法，同时避免全身性中毒。

Pharmacokinetics , systemic toxicity and immunogenicity of recombinant methioninase in primates

重组蛋氨酸酶在猕猴体内的药动学、免疫原性及系统毒性

Results 2 of 16 cases ( 12.5 % ) relapsed . 5 cases complained of local toxicity with no systemic toxicity happened .

结果16例患者中有2例复发（12.5%），5例患者出现局部毒性反应，无全身毒性反应发生。

Objective To gain some insight into acute local and systemic toxicity reation after hyperthermic isolated perfusion of DDP .

目的观察高温顺铂肢体区域性隔离灌注的局部和全身不良反应。

Conclusions : Without significant systemic toxicity , local direct injection of Fas monoclonal antibody into solid tumor tissue had therapeutic effect on carcinoma cells expressing Fas .

结论：直接局部注射Fas单克隆抗体对表达Fas的小鼠膀胱实体肿瘤具有治疗作用，可明显延长荷瘤小鼠的存活期，且无明显的全身毒副作用。

The hemolysis experiment and the acute systemic toxicity experiment prove , this method for the preparation of high viscosity chitosan composite film has the advantages of biological safety .

溶血实验和急性全身毒性实验初步证明，本文方法制备的高黏度壳聚糖复合膜具有生物安全性。

The extracting liquid of submandibular gland acellular matrix scaffold material was made , and its toxicity effect to the body was analyzed by acute systemic toxicity test .

制备领下腺脱细胞基质支架材料的浸提液，通过急性全身毒性试验，分析脱细胞后的生物衍生支架材料对机体的毒性作用。

ADEPT is a kind of very promising immune treatment for cancer . The method can be add to result of treatment for cancer , and avoiding seriously systemic toxicity .

肿瘤单抗&酶/抗癌前药（ADEPT）治疗是一种非常有前景的肿瘤免疫治疗方法，该方法可以增加肿瘤的治疗效果，同时避免严重的全身毒性。

There was no excessive systemic toxicity in this assay except for slightly increased liver weight in the highest AN-treated group ( P < 0 05 ) .

丙烯腈各剂量组除最高剂量组肝脏重量有轻微增加外（P<0.05），受试动物未出现明显系统毒性。

Conclusions : The addition of fentanyl plus pancuronium to the lidocaine solution reduces the dose of the local anesthetic and and possibly systemic toxicity .

结论：0.25%利多卡因混合芬太尼-潘库溴铵具有0.5%利多卡因相同的静脉局部麻醉效果，可减少局麻药剂量和潜在系统毒性。

The treatment methods commonly used in combination with chemotherapy , but the anti-tumor capabilities of these therapeutic measures , that is , poor selectivity , and have a significant systemic toxicity .

通常采用的联合化疗的治疗方法，但这些治疗措施抗肿瘤能力低，也就是选择性差，并有明显的全身毒副作用。

METHODS : The biological safety was evaluated through the experiments including hemolysis test , short-term systemic toxicity test , oral mucous membrane irritation test and cytotoxicity test ( MTT test ) .

方法：分别通过溶血试验、口腔黏膜刺激试验、细胞毒性试验（MTT法）和急性全身毒性试验，初步评价纯钛表面聚吡咯涂层的生物安全性。

Objective To provide literature basis and ideas for the research of systemic toxicity based on effective and toxical composition of Evodia rutaecarpa ( Juss . ) Benth .

目的为进行基于功效和物质基础的吴茱萸系统毒性研究提供文献依据和研究思路。

Result : Self designed NECM scaffold biomaterial for cell culture has no cytotoxicity , no acute and subacute systemic toxicity , and it did not cause inflammatory reaction .

结果：自制NECM支架材料无细胞毒性，无溶血现象，无全身毒性，无致热源作用，无致敏淋巴细胞作用，体内埋植不引起炎症反应。

Methods : five tests were taken up according to ISO standards including acute systemic toxicity test , hemolysis test , cytotoxicity test , dermal stimulation test and oral mucosal membrane stimulation test .

方法：根据ISO标准，采用急性全身毒性试验、溶血试验、细胞毒性试验、皮肤刺激试验和口腔粘膜刺激试验对玻璃陶瓷进行评估。

For chemotherapy , as the majority of HCC cells was tolerance to chemotherapy drugs . Increased the dose of chemotherapy drugs in patients would cause systemic toxicity and caused multiple organ failure .

对于化疗来说，由于大多数肝癌细胞对化疗药物不敏感，增加化疗药物的剂量会造成患者全身的毒副作用，引发多器官功能衰竭。

Articular injection administration has drawn much attention recently when it comes to the treatment of rheumatoid arthritis which has a rapid onset , can avoid systemic toxicity and improve drug bioavailability .

关节腔注射给药治疗类风湿性关节炎具有起效快、避免全身毒副作用、提高药物生物利用度等优点，在近年来引起广泛关注。