rofecoxib

Unfortunately , cardiovascular side-effects have recently been reported in patients using another selective COX-2 inhibitor , rofecoxib .

然而，最近有报道显示应用另一种选择性COX-2抑制剂-罗非昔布-的患者中有心血管副作用的发生。

Rofecoxib , a COX-2 specific inhibitor , is approved for treatment of osteoarthritis , acute pain and primary dysmenorrhea .

罗非昔布是高选择性环氧化酶（COX-2）抑制剂，用于治疗骨关节炎，控制成人锐痛和痛经。

Combined therapy with rofecoxib and radiotherapy results in enhanced antitumor effects

Rofecoxib放疗增敏作用的实验研究

Rofecoxib in the acute treatment of migraine : A randomized controlled clinical trial

罗非考昔在急性偏头痛治疗中的作用：一项随机对照临床试验

The Effects of COX-2 Inhibition Rofecoxib on Retinal Angiogenesis in the Mouse

环氧合酶-2抑制剂Rofecoxib抑制小鼠视网膜新生血管形成的实验研究

The inhibition of Rofecoxib to the formation of rabbit atherosclerosis plaques

Rofecoxib对兔动脉粥样硬化斑块形成的抑制作用

The findings also support prior research linking rofecoxib ( Vioxx ) with adverse cardiovascular effects .

该研究也支持以前关于罗非考昔（Vioxx）与心血管副作用相关的结论。

Influence of rofecoxib , a high selective cox-2 inhibitor , on articular cartilage of rats

高选择性环氧化酶-2抑制剂罗非昔布对大鼠关节软骨的影响

Rofecoxib improved response rate and several quality-of-life items , including pain-related items and global quality of life .

罗非考昔可提高患者治疗反应率和数个生活质量项目，包括疼痛相关项目和总的生活质量。

And the selective inhibitor of COX-2 as rofecoxib could control the attack of migraine pain in clinical practice .

临床实验也表明，选择性COX-2抑制剂如罗非考昔可有效控制偏头痛急性发作。

Comparison of Preemptive Analgesia Efficacy between Etoricoxib and Rofecoxib in Ambulatory Gynecological Surgery

罗非昔布和依他昔布在妇科小手术中的预先性镇痛效果

Influence of High Selective Cox-2 Inhibitor & Rofecoxib on the Collagen of the Articular Cartilage of Rats ' Osteoarthrosis

罗非昔布对大鼠骨关节病关节软骨胶原的影响选择性脊神经后根切断术治疗痉挛性脑瘫

Differences in outcomes of patients with congestive heart failure prescribed celecoxib , rofecoxib , or non-steroidal anti-inflammatory drugs : population based study

充血性心力衰竭患者服用塞来昔布、罗非昔布或非甾体抗炎药的结果差异：以人群为基础的研究

Effect of rofecoxib on expressions of VEGF and inducible NOS in human gastric carcinoma tissues established in nude mice by orthotopic transplantation

罗非昔布对裸鼠人胃癌原位种植瘤组织中血管内皮生长因子和诱导型一氧化氮合酶表达的影响

Objective To study the effect of rofecoxib on colon neoplasm of rat induced by DMH and ERK / pERK expression .

目的研究选择性COX2抑制剂罗非昔布对大鼠结肠肿瘤的防治作用及对肿瘤组织细胞外信号调节蛋白激酶（ERK/pERK）表达的影响。

Proliferation of gastric cancer cell line affected with rofecoxib or octreotide was determined by 3H-thymidine ribotide incorporation .

采用3H胸腺嘧啶掺入观察药物对胃癌细胞DNA合成的影响。

Objective : To compare the safety and efficacy of loxoprofen and rofecoxib in treatment of knee osteoarthritis ( OA ) .

目的：对比洛索洛芬和特异性环氧化酶2（COX2）抑制剂罗非昔布治疗膝骨关节炎（OA）的疗效和安全性。

Further analysis showed that of the various NSAIDs evaluated , only rofecoxib and ibuprofen increased the risk of cardiovascular events across patient subgroups .

对不同的非甾体抗炎药的评估后进一步分析显示，在整个患者亚群中仅仅罗非考昔和布洛芬增加了心血管事件发生的风险。

It is consequently likely that the lithium intoxication was induced by concomitant administration of rofecoxib causing a reversible decrease in renal function .

因此，很可能是锂中毒引起罗非考昔治疗后发生可逆性肾功能减退。

Rofecoxib significantly increased the incidence of diarrhoea and decreased constipation , fatigue , fever , weight loss , and pain , and analgesic consumption .

罗非考昔能显著增加腹泻和降低便秘、疲劳、发热、体重减轻、疼痛和止痛剂消耗发生率。

Methods The rats were randomly divided into 3 groups : MI group , MI plus rofecoxib group and MI plus valeryl salicylate group .

方法实验大鼠随机分为心肌缺血加选择性COX2抑制剂罗非昔布组、心肌缺血加选择性COX1抑制剂valerylsalicylate（VS）组和单纯心肌缺血组。

The MI rate ratio with rofecoxib use was1.59 in patients with a prior MI and1.23 in those without a previous MI .

使用罗非昔布并且有心梗病史的患者心梗发生率为1.59%，而没有心梗病史的患者心梗发生率只有1.23%。

Conclusion : Rofecoxib administrated for a long term has no harm influence on the collagenic metabolism of the rats ' knee joints cartilage in experimental osteoarthrosis .

结论：长期服用罗非昔布对大鼠骨关节病关节软骨的胶原代谢无明显影响。

AIM : To observe the influence of rofecoxib , a non steroidal anti inflammatory drug , administrated for a long term on the knee joints cartilage of rats .

目的：考察长期服用高选择性环氧化酶2（COX2）抑制剂（罗非昔布）对大鼠关节软骨的影响。

Objective : To explore the effect of specific cyclooxygenase-2 inhibitor ( Rofecoxib ) on the expression of plasminogen activator inhibitor type-1 in MRL / lpr mice .

目的：探讨特异性环氧化酶（COX）-2抑制剂（Rofecoxib）对MRL/lpr自发狼疮小鼠肾脏纤溶酶原激活物抑制剂-1（PAI-1）表达的影响。

It is found that the structures of open-loop derivatives are similar to the structure of Rofecoxib , and the structure-activity relationships are similar to that of other COX-2 inhibitors .

结构优化表明活性RC开环衍生物具有类似RC的立体结构，构效关系研究也表明该类新型RC开环衍生物具有其它环氧合酶选择性抑制剂相似的构效关系。

In this study , we observe the growth of three kinds of tumor cell lines after using rofecoxib and celecoxib , then , detect the apoptosis rate by FCM , so as to approach the negative mechanisms .

本实验将两种Cox&2抑制剂（罗非昔布、塞来昔布）作用于三种肿瘤细胞系，观察细胞的增殖变化，并通过流式细胞仪检测凋亡率，对这种药物的抑瘤机制进行探讨。

The expression of iNOS protein in isotonic saline group , rofecoxib group and combination group was 73.75 % , 52.50 % , and 26.67 % respectively , being significantly different among groups ( P < 0.05 ) .

iNOS的表达显示：对照组iNOS阳性率为73.75%，罗非昔布组为52.50%，联合组为26.67%，罗非昔布组与对照组相比，差异有显著性（P<0.05）。

Results : Rofecoxib has no significant influence on the total amount of collagen and the metabolism of the type ⅱ and type ⅲ collagen even it was administrated for a long term , but the amount of the type ⅰ collagen increased significantly .

结果：罗非昔布长期服用，对骨关节病关节软骨胶原的总量无影响，对Ⅱ，Ⅲ型胶原代谢无影响，而使Ⅰ型胶原含量明显增加。

Methods After the models of human gastric carcinoma in nude mice by orthotopic transplantation were established , rofecoxib was administered intragastrically . The expressions of VEGF and iNOS were evaluated in the local tumors by Envision immunohistochemical method .

方法建立裸鼠人胃癌原位种植转移模型，以罗非昔布给裸鼠灌胃，通过免疫组化Envision法检测罗非昔布对原位种植瘤胃癌组织中VEGF、iNOS蛋白的表达。