peripheral tolerance

As a necessary subset of natural occurring regulatory T cells , CD4 + CD25 + regulatory T cells ( Tregs ) play an important role in modulating the immune system and maintaining peripheral tolerance .

CD4+CD25+调节性T细胞（regulatoryTcells，Tregs）是天然产生的调节性T细胞的重要亚群之一，在调控免疫系统和维持外周耐受方面起着重要作用。

This review focuses on the mechanisms of autoreactive T cells escaping peripheral tolerance , migration from blood to hair follicles , and evidence that alopecia areata is mediated by T cells .

综述自身反应性T细胞逃逸外周耐受、从外周血向毛囊迁移，及其介导斑秃发病的证据。

Recently investigations indicated that DCs play a critical role in the peripheral tolerance .

近年更多的研究表明，DC在外周免疫耐受中起关键性作用。

More recent researches have shown that regulatory T cell is a key element in peripheral tolerance .

越来越多的研究表明调节T细胞是外周免疫耐受的关键。

Regulatory T cells ( Tregs ) play an essential role in modulating the immune system and maintaining peripheral tolerance .

调节性T细胞（Tregs）在免疫调节和维持外周免疫耐受方面起重要作用。

But at present , neither the central nor the peripheral tolerance strategies get great achievement because of the complicated manipulation method or unsure effects .

但目前无论是中央型还是外周型耐受均因操作复杂或效果不确定而无法奏效。

It is thought that Treg cells play a critical role in peripheral tolerance , especially in maternal immunotolerance to the fetus .

调节性T细胞是一类在免疫调节中不可缺少的T细胞群，并且认为它在外周耐受尤其是在母胎免疫耐受中起重要作用。

The exosomes produced by immature DCs can maintain peripheral tolerance , while exosomes produced by mature DCs can stimulate effector T cells . Therefore the exosomes play a important role in inducing immune tolerance .

非成熟DC（iDC）产生的外染色体能够维持外周耐受，而成熟DC（mDC）产生的外染色体能够刺激效应性T细胞，因此外染色体在诱导免疫耐受中发挥着重要作用。

Recently , dendritic cells ( DCs ) are found to play a dual role in the immunological system . Apart from inducing immune response as antigen presenting cells ( APCs ), DCs can also induce central and peripheral tolerance .

近年来，树突状细胞（Dendriticcells，DCs）被发现在免疫系统中扮演着双重角色，除作为抗原提呈细胞（Antigenpresentingcells，APC）诱发免疫反应外，还能诱导中枢或周围性免疫耐受。

T cells apoptosis mediated by Fas / FasL is a major mechanism for peripheral immune tolerance .

Fas/FasL介导的T细胞凋亡是机体诱导和维持外周免疫耐受的重要机制[10,11]。

CONCLUSION : The relative reduce of CD4 + CD25 + Tr can lead to the breakdown of peripheral autoimmune tolerance .

结论：CD4+CD25+Tr细胞的相对降低，引起外周耐受状态的打破；

Conclusion HBV infection induces apoptosis of PBMC . AICD may be one of the important mechanisms of peripheral immune tolerance in HBV chronic infection .

结论HBV感染可能具有诱导PBMC凋亡的能力，AICD可能是形成HBV慢性感染免疫耐受的一个重要机制。

In addition , peripheral immune tolerance can be obtained by blocking the conduction of B7 / CD28 and CD40 / CD40L specifically .

另外，通过特异性阻断协同刺激信号B7/CD28以及CD40/CD40L的传导，可获得外周性免疫耐受。

TO study the mechanism of peripheral T cell tolerance induced by superantigen staphylococus aureus enterotoxin B ( SAgSEB ) .

本研究目的是探讨在超抗原金黄色葡萄球菌肠毒素（SEB）诱导外周T细胞免疫耐受的作用机制。

Molecular Mechanism of Ye 's Lupus Formula on Induction of Peripheral Blood T Lymphocytes Tolerance in the Patients with Lupus Nephritis

叶氏狼疮方诱导狼疮肾炎患者T细胞免疫耐受分子机制研究