nuclear receptor superfamily

Progress in nuclear receptor superfamily and nuclear receptor regulator

核受体超家族及其辅调节子的研究进展

Estrogen receptor β( ER β) is a ligand-regulated transcriptional factor , which belongs to the nuclear receptor superfamily .

雌激素受体β（ERβ）属于核受体超家族成员，是一类配体调节的转录因子。

The nuclear receptor superfamily is composed of a large number of ligand-dependent transcriptional factors that mediate expression of genes associated with eukaryotic growth , development , and homeostasis .

核受体超家族属于反式作用因子，是一类配体依赖性转录因子，其成员广泛介导了真核生物与生长、发育和内环境稳定相关基因的表达。

The estrogen-related receptor ERR , belonging to the nuclear receptor superfamily , is the first orphan nuclear receptor to be identified . ERR comprise ERR α, ERR β and ERR γ .

雌激素相关受体（estrogen-relatedreceptor，ERR）属于核受体超家族，是第一个发现的孤儿核受体，包括ERRα，ERRβ和ERRγ。

In the past , scientists persist that estrogen signals through ligand regulated transcription factors of the nuclear receptor superfamily . Estrogens binds to classical estrogen nuclear receptors ( ER ), then activate a serial of transduction signal proteins to elicit biological effects .

过去人们认为雌激素通过与经典的雌激素核受体结合，启动相关的基因效应，激活其下游一系列的信号转导蛋白而发挥相应的生物学作用。

Estrogen receptor β( ER β), which belongs to the nuclear receptor superfamily and has high homology to ER α, is a ligand-regulated transcriptional factor . ER β is expressed in many tissues such as breast and so on , and has important physiological and pathological functions .

雌激素受体β（ERβ）与雌激素受体α（ERα）的结构相似，是一类配体调节的转录因子，属于核受体超家族，分布于乳腺等多种组织中，具有重要的生理病理学意义。

Background Liver X receptors ( LXRs ) are members of the nuclear hormone receptor superfamily which involve in energy metabolism of intracellular cholesterol and glucose regulation .

背景肝X受体是一种核受体，与细胞内胆固醇及糖等能量代谢有关。

Thyroid hormone receptors ( TRs ) belong to the nuclear hormone receptor superfamily . TRs are coded by two separate genes , TR α and TR β .

甲状腺激素受体（TRs）属于核受体超家族，由TRα和TRβ基因编码。

PPAR ( Peroxisome proliferator-activated receptors ), are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily that functions as critical regulators of lipid and energy homeostasis .

PPAR（peroxisomeproliferator-activatedreceptor），即过氧化物酶体增殖剂激活受体，是一类由配体激活的核转录因子，为核受体家族的一员。PPAR在调节脂类代谢及机体能量代谢平衡方面有重要作用。

Background and Objective : Peroxisome proliferator-activated receptors ( PPARs ) are a class of ligand-activated nuclear transcription factor belonging to the nuclear receptor superfamily .

研究背景和目的：过氧化物酶体增殖物激活受体（PPARs）是一类由配体激活的核转录因子，属于核内受体超家族成员。

GCNF ( Germ Cell Nuclear Factor ) is a member of nuclear receptor superfamily and also an orphan receptor .

GCNF（GermCellNuclearFactor）属于核受体超家族成员，是一个孤儿受体。

Peroxisome proliferator activated receptor γ ( PPAR γ ) is a very important ligand activated nuclear transcription factor , belonging to nuclear hormone receptor superfamily .

过氧化物酶体增殖剂活化受体γ（PPARγ）是一个由配体激活的核转录因子，属于核激素受体（nuclearhormonereceptor）超家族。

Objective To explore the expression and distribution of germ cell nuclear factor ( GCNF ), an orphan receptor of the nuclear receptor superfamily which is supposed to have multifunction including spermatogenesis , neurogenesis and embryo development , in adult rat epididymis and young rats during postnatal development .

目的探讨生殖细胞核因子（GCNF）在大鼠附睾中的时空表达与分布。