nnk

The results indicated that the malignant transformation induced by NNK was a sequential process .

以上结果表明NNK致BEP2D细胞恶性转化是一种多阶段的发展过程。

Welding robot and automatic welding equipment of NNK

日本NKK焊接机器人和自动化焊接装备

NNK induced human bronchial epithelial cell line neoplastic transformation and its mechanism of oxidative damage

NNK诱发人支气管上皮细胞恶性转化及氧化损伤机理研究

Molecular mechanism of Bcl2 inhibiting the repair of DNA damage induced by NNK

Bcl2抑制NNK诱导的DNA损伤后修复的分子机制研究

Inhibition of Bcl2 to DNA damage repair induced by NNK

Bcl2对NNK诱导的DNA损伤后修复的抑制作用

Induction of pulmonary precancerous lesions by tobacco-specific NNK in Wistar rats

烟草致癌原NNK诱发大鼠肺癌前病变的实验研究

Malignant transformation of HPV 18 immortalized human bronchial epithelial cells induced by tobacco specific nitrosamine NNK

烟草甲基亚硝胺吡啶基丁酮诱发HPV-18永生化人类支气管上皮细胞恶性转化

Results : ( 1 ) Associate effect of alpha particles and NNK on cell survival was found , in which there was difference with administration order .

[结果]（1）α粒子和NNK联合作用对BEP2D细胞存活的影响具有明显的协同作用，并与两者作用顺序有关。

However , there was an individual variation in response to indirect-acting carcinogens NNK and BaP .

然而间接作用致癌物NNK和BaP引起的反应有明显个体差异。

Study of Hemoglobin Adduction with NNK In Vivo by ~ ( 14 ) C-AMS

~（14）C-加速器质谱法研究NNK与血红蛋白的体内加合作用

This carcinogen is known as NNK .

这种致癌物被称为NNK。

Conclusion : The NS can inhibit NNK induced lung tumorigenesis in mice with a better dose response relationship , and the mechanism may be related to immunoregulation of selenium .

结论：NS对NNK诱发小鼠肺癌有明显防治作用，并有较好的剂量效应关系，其机理可能与硒的免疫调节作用有关。

The malignant transformation of HPV 18 immortalized human bronchial epithelial cell ( BEP2D ) induced by tobacco specific nitrosamine NNK and its biological characteristics were investigated .

观察了烟草特异亚硝胺NNK诱发HPV－18永生化人类支气管上皮细胞（BEP2D）恶性转化过程中细胞生物学特征的变化。

To study the biological characteristic and ultrastructure during the malignant transformation of human bronchial epithelial cell ( BEAS-2B ) induced by tobacco-specific nitrosamine ( NNK ) .

目的：探讨烟草特异性亚硝胺（NNK）诱发人支气管上皮细胞（BEAS－2B）恶性转化过程中生物学特性及超微结构变化情况。

NNK jointly with the remaining three combinations produced by the cells of the micronucleus rate in the combined effects in these five detriments about ten portfolios is the three smallest .

与NNK联合的其余三个组合（NNK+NH3，NNK+Crotonaldehyde，NNK+Phenol）所产生的细胞微核率在这五种有害物质联合作用的十个组合中是最小的三个组合。

As part of the formula , they measured a biological marker , total NNAL , which indicates the amount of exposure to the tobacco-specific lung cancer-causing agent NNK .

作为公式的一部分，他们测定了生物标记物&总NNAL含量，它能够反应烟草特异致肺癌成分NNK的含量。

In lamina , the content and proportion of NAT were higher than that of NNK , while in midrib , NNK was higher than NAT in content .

叶片中NAT含量和比例一般高于NNK，而在主脉中NNK含量高于NAT。

Conclusion The model of malignant transformation of BEAS - 2B cells induced by NNK could be created successfully and provided for investigating the molecular biological mechanism of lung cancer , especially smoking - related cases .

结论：NNK能成功诱发人支气管上皮细胞（BEAS-2B）细胞恶性转化，为进一步探讨肺癌发生机制、尤其是吸烟致肺癌发生机制提供了理想模型。

Conclusion : NNK serves as pharmic preconditioning role by regulating ET 1 and NO in blood and cerebral tissue . NNK has the function of simulating or strengthening CIPC .

结论：NNK通过调控血及脑组织的ET1、NO而扮演药物预适应角色，具有模拟或强化CIPC的作用。

In addition , the survival rates of the cells in groups exposed to alpha particle irradiation followed by NNK administration were significantly lower than that of cells treated with NNK administration followed by alpha particle irradiation .

此外还发现α粒子照射后NNK染毒的细胞存活率明显低于NNK染毒后α粒子照射组。

Conclusion : NNK can adjust CD 62P level stability on two kinds of models and its effect is similar to ASP . So NNK may have function to induce and tonify IPC and protect brain neuron .

结论：NNK颗粒对两种模型均有稳定调整CD62P的效应，其强度与ASP持平，其机制可能与诱导和强化IPC作用、从而保护脑神经元有关。

It releases into your body when you inhale smoke , quickly passes through the liver , gets metabolized and releases NNAL , a byproduct of NNK , into the bloodstream .

当你吸烟时，它会在身体里扩散，迅速穿过肝脏代谢并释放出NNAL，然后产生NNK，进入血液。

Subtracted the NNK effect , DNA damage , HPRT gene mutation frequency and cell micronucleus frequency in the group irradiated by alpha particles in combination with NNK administration were significantly higher than those of alpha particles irradiation alone .

扣除NNK效应后，α粒子和NNK联合作用诱发BEP2D细胞DNA损伤、HPRT基因突变率、以及细胞微核率也明显高于α粒子单独照射组。

Objective : To investigate whether nanoselenium ( NS ) can prevent lung tumorigenesis in Kunming mice induced by tobacco specific nitrosamine 4 ( methylnitrosamino ) 1 ( 3 pyridyl ) 1 butanone ( NNK ) .

目的：研究烟草特异亚硝胺4甲基亚硝胺1（3吡啶）1丁酮[4（methylnitrosamino）1（3pyridyl）1butanone，NNK]诱发昆明小鼠发生肺癌及纳米硒对肺癌的防治作用。

Results In the group exposed to both alpha particles irradiation and NNK , DNA damage , HPRT gene mutation frequency , and cell micronucleus frequency were significantly higher than those in the same dose groups irradiated with alpha particles or NNK administration alone .

结果与相同剂量NNK或α粒子单独作用比较，α粒子和NNK联合作用诱发BEP2D细胞DNA损伤、HPRT基因突变率、以及细胞微核率均显著增高；

Cigarette smoke condense ( CSC ) was collected from a famous brand cigarette ( mixed cigarette , the amount of tar were marked by 8 mg per cigarette ), and the content of NNK in the CSC was detected by GC , TEA .

某种知名品牌卷烟（混合型，标示焦油量为8mg/支）用于制备CSC，并通过气相色谱-热能分析联用仪（GC-TEA）检测其NNK含量；

The results showed that the contents of NNN , NAT , NAB , NNK and total TSNAs in tea filter flue-cured cigarette mainstream smoke were reduced by 16.88 % , 15.12 % , 26.04 % , 11.39 % and 14.61 % , respectively .

检测结果表明：与普通滤嘴卷烟相比，烤烟型茶质滤嘴卷烟烟气中NNN、NAT、NAB、NNK、亚硝胺总量分别降低了16.88%、15.12%、26.04%、11.39%、14.61%；