maximum tolerated dose

In this paper , the estimation of the maximum tolerated dose of a drug for phase I clinical trials is investigated .

这篇论文主要研究的是第Ⅰ阶段临床试验中最大耐受剂量的估计问题。

The main purpose of phase I clinical trials is to estimate the maximum tolerated dose of a new drug which will be passed for further testing in phase II trials .

第Ⅰ阶段临床试验的主要目的就是估计人体对研究新药的最大耐受剂量，确保Ⅱ期试验科学、有效地进行。

Result : The maximum tolerated dose of the capsules in mice was 126 7 g / kg .

结果：小鼠口服的最大耐受量（MTD）为126.7g总药材/kg体重。

He said the issue with cancer drugs is to find the maximum tolerated dose thats most likely to have an anti-cancer effect .

他说有癌药物的问题是要找出最大容忍剂量，其是最可能的是有一抗癌的影响的。

Part of elements intake were more beyond the DRIs , but did not exceed the maximum tolerated dose . 3 .

病区和非病区居民部分元素摄入超过DRIs，但均未超过最高耐受量。

The extract was safe and nontoxic , the maximum tolerated dose in mice is more than5g / kg .

说明该提取物安全无毒，小鼠最大耐受量超过5g/kg。

The results showed that female moth silkworm powder has obvious anti-oxidation . ( 3 ) Maximum tolerated dose was used to detect acute toxic effects of female silkworm moth powder powder .

研究结果显示，家蚕雌蛾粉具有明显的抗氧化作用。（3）采用最大耐受剂量法，检测家蚕雌蚕蛾粉急性毒性作用。

Acute toxicity test in mice was not found to have acute mortality , and the maximum tolerated dose of drugs were tens or hundreds of times more than the clinical dose . 2 .

结果：1.冠心苏合丸系列药材在小鼠急性毒性试验中未发现有急性死亡现象，且药物的最大给药量均超过临床剂量的几十倍甚至几百倍。

Conclusion : Both tissue cultured protocorm and natural medicinal materials from Dendrobium candidum could improve immunological function with similar potency . The maximum tolerated dose was 227 times as high as the effective clinical .

结论：铁皮石斛组织培养原球茎与原药材均具有提高免疫功能作用，两者作用强度相似，最大耐受量相当于人临床用药量的227倍。

Traditional tumor chemotherapy is generally known as the maximum tolerated dose therapy using a longer time interval ( eg 2-3 weeks ) administration to ensure that human normal tissues in the interval between administrations could recover .

传统的肿瘤化疗方案一般是采用最大耐受剂量间隔较长时间（如2-3周）给药，以确保人体正常组织在给药间隔期间得以适当的修复。

Objective To evaluate the dose-limiting toxicity ( DLT ), efficacy and maximum tolerated dose ( MTD ) of capecitabine with concurrent radiotherapy in patients with node-positive stage ⅱ nasopharyngeal cancer .

目的探讨希罗达对鼻咽癌增敏放疗的剂量限制毒性（DLT）和最大耐受剂量（MTD），同时观察疗效。

The maximum tolerated dose ( MTD ) was defined as the dose that more than 8 of 10 patients could tolerate the dose-limiting toxicity ( DLT )( grade ≥ⅲ radiation injuries ) .

最大耐受剂量定义为10例患者中有至少有8例患者能耐受剂量限制毒性（≥Ⅲ级的放射性损伤）。

The purpose of this article was to study the maximum tolerated dose ( MTD ) and the dose limiting toxicity ( DLT ) of human body to simultaneously intravenous infusion of 5 FU and CF.

本研究目的是探讨同时持续静脉滴注CF与5-FU，人体对5-FU的最大耐受剂量（maximumtolerateddose，MTD）及剂量限制性不良反应。

2.1t was proved that the maximum tolerated dose of mice on thyroprotein exceeded 8g / kg through the test of acute toxicity by the way of pouring into stomach with thyroprotein .

急性毒性实验通过灌胃给药途径证明小白鼠对碘化酪蛋白的最大耐受量大于8g/kg，属于实际无毒级。

Currently , chemotherapy is the main treatment to the hormone-independent prostate cancer , and usually the maximum tolerated dose will be chosen which is based on high-dose chemotherapy . The significant side effects limit its widespread use in the clinic .

目前，化疗是激素非依赖前列腺癌的主要治疗手段，且通常采用以最大耐受量为基础的大剂量化疗方案，由于毒副作用明显，限制了其在临床中的广泛使用。

CONCLUSION : Administration of metoprolol plus the conventional therapy for heart failure significantly improved the clinical symptoms and cardiac function in patients with CCHF , but whether the normal dose could be increased to maximum tolerated dose depends on the administration technique .

d-1的剂量。结论美托洛尔在常规治疗心力衰竭基础上能显著改善患者临床症状及心功能，能否加至最大耐受剂量，有赖于应用技巧。