leucine zipper

Sequence analysis showed that the deduced protein contained a leucine zipper and a possible nuclear localization signal domain .

DNA序列分析表明，其编码产物含有一个亮氨酸拉链结构域和一个核定位信号肽。

The two cDNA isoforms-cepo-A and cepo-B code 99 and 142 animo acid polypeptides respectively , a leucine zipper sequence pattern existed in the C-terminus of these two protein isoforms .

cepo-A和cepo-B分别编码99和142个氨基酸。在这两种蛋白质异构体的C末端均存在一个亮氨酸拉链结构域。

The typical structure of Mx protein includes triplet ATP / GTP binding domain , dynamic family protein sequence leucine zipper and its orientation signal .

Mx蛋白具有典型的结构特征，包括三联体ATP/GTP结合区、发动蛋白家族结构的特征序列以及亮氨酸拉链结构和定位信号。

The mammalian CREB / ATF family represents a large group of basic-region leucine zipper ( bzip ) transcription factors with rather diverse physiological functions .

哺乳动物CREB/ATF转录因子家族是一个碱性区-亮氨酸拉链（basic-regionleucinezipper，bzip）蛋白大家族，参与细胞增殖和分化、胚胎发育、学习记忆和肿瘤发生等多种生理过程。

Objective To detect the possible epitopes of 52 000 dalton Ro / SSA autoantigen and selectively clone the antigen fragment containing the leucine zipper motif .

目的预测相对分子量为52000的Ro/SSA自身抗原的可能表位，并选择性克隆含亮氨酸拉链氨基酸序列的抗原片段。

In addition , the C terminal region of the Mx proteins contains the localization signals and the leucine zipper motif which account for the trimerization of Mx in the cell .

在蛋白C端存在使Mx蛋白形成三聚体的Leu拉链结构以及定位信号。

Adenovirus E4 promoter-binding protein 4 ( E4BP4 ), a mammalian basic leucine zipper ( bZIP ) nuclear transcription factor , was identified to be involved in cell survival and proliferation .

腺病毒E4启动子结合蛋白-4（E4BP4）是哺乳动物细胞核内的一种碱性亮氨酸拉链（bZIP）型转录因子，参与调控细胞的存活和增殖。

Conclusion The 52 000 dalton Ro / SSA autoantigen has good antigenicity . The cloning of the antigen fragment will help to elucidate the possible role of leucine zipper motif in forming the epitope of the antigen .

结论52000Ro/SSA多肽抗原性好，所获得的抗原片段为今后研究亮氨酸拉链氨基酸序列在该抗原表位形成中的作用奠定了基础。

The homeodomain leucine zipper proteins ( HD-Zip ) are special transcription factors in higher plants . HD-Zip is characterized by a highly conserved homeodomain and a leucine-zipper domain linked closely to the C-terminal of the homeodomain .

同源域&亮氨酸拉链蛋白（HD-Zip）是高等植物中特有的一类转录因子，包含高度保守的同源异型域（HD），HD羧基末端与亮氨酸拉链域（LZ）紧密相连。

A proto-oncogene Fos-related antigen ( Fra ) - 1 is a FOS family member and an AP-1 transcription factor component . Through their leucine zipper domain , Fra-1 proteins form heterodimers with Jun proteins , which control transcription of target gene .

原癌基因Fra-1是核转录因子AP-1家族的成员，通过亮氨酸拉链结构域与Jun蛋白形成异源二聚体，调控靶基因的转录。

Preparation of Antibodies Against a Novel Leucine - zipper Protein , Ecp

果蝇中Ecp蛋白的表达、纯化与抗体制备

Site-directed mutant of human lrg were constructed successfully , the second leucine was switched to serine in the Leucine zipper domain .

结果获得了针对Hlrg基因的定点突变体，亮氨酸拉链中的第二个亮氨酸被突变成丝氨酸。