highly conserved sequence

Localization and clone of four segments of highly conserved sequence of β ig-h3 gene and construction of their prokaryotic expression vector

βig-h3基因4段高度保守序列定位、克隆及原核表达载体的构建

According to the reportes about highly conserved sequence of apple trees , pear trees or the other woody years plants and the model plant Arabidopsis thaliana , the proper primers were designed by primer premier 5.0 and oligo 6.0 software .

2利用PrimerPremier5.0、oligo6.0等软件根据已报道的苹果、梨等果树和模式植物拟南芥相关基因的高度保守序列设计了简并引物。

On our conjecture , Gene 3A , a highly conserved sequence , may be the determinant of the virulence of FMDV . Changes in 3A have been associated with altered host range .

我们根据已有资料推测，3A基因可能是口蹄疫病毒的毒力决定簇，它具有高度保守性，其变异和部分缺失对病毒在牛体内的致弱和宿主嗜性发生改变起重要作用。

There exist highly conserved sequence motifs including W , X , Y , CCAAT , and TATA-like boxes in the obtained sequences , showing the same organization of the conserved regulatory elements as in other species .

分析发现所得序列中存在与MHCⅡ类基因表达调控有关的高度保守的W、X、Y、CCAAT及类TATA调控元件，调控元件的空间组织顺序也与其他物种相应序列的相同。

CREB binding protein ( CBP ) is a crucial transcriptional coactivator , which contains highly conserved sequence and can interact with about 300 kinds of transcription factors , and is considered to be the key point of the regulation of mammalian genes transcription .

CREB结合蛋白（cAMPresponseelementbindingproteinbindingprotein，CBP）是一种重要的转录辅激活因子，具有高度保守的序列，能够与300多种转录因子相结合，被认为是哺乳动物基因转录调控中的关键位点。

CONCLUSION : CVB2 Yunnan strain shows the highest similarity to Ohio 1 strain , and they are closely related , which is characterized by two valines deletion in the major neutralizing immunogenic epitope and regular variation with a highly conserved sequence in the common antigenic determinants of CVB .

结论：CVB2云南分离株与Ohio-1株同源性最高，亲缘关系最近，以主要中和抗原表位区存在缬氨酸缺失，CVB共同抗原表位区存在具有规律性的变异及保守序列等为其主要分子特征。

The common feature of these membrane proteins is the tendency on the trimer and they share highly conserved amino acid sequence in their primary structures .

这些膜蛋白的共同特征是具有生物活性形式的三聚体，及在分子一级结构上的高度保守氨基酸残基序列。