gyrase

The results indicated that the danofloxacin inhibited the DNA gyrase mainly .

表明单诺沙星对DNA旋转酶的抑制是PAE产生的机制之一。

Inhibitory effect of 5 quinolones on DNA gyrase from Staphylococcus aureus

5种喹诺酮抗菌药对金葡菌DNA螺旋酶的抑制作用

High level quinolone resistance require mutations in both DNA gyrase gene and topoisomerase ⅳ gene .

高水平的耐药由DNA回旋酶和拓扑异构酶Ⅳ同时发生变异造成。

OBJECTIVE To study the mutation in DNA gyrase A of Escherichia coli resistante to quinolone antibiotics .

目的研究导致大肠埃希菌DNA回旋酶A亚单位的基因变异耐喹诺酮类药物的机制。

It can affect the function of DNA gyrase in bacteria , which results in the inhibition of the duplication and transformation of DNA .

左氧氟沙星可通过作用于细菌的脱氧核糖核酸旋转酶，抑制细菌DNA的复制和转换，发挥广谱抗菌作用。

DNA gyrase is the only topoisomerase that is able to introduce negative supercoils into DNA .

DNA旋转酶是类型Ⅱ拓扑异构酶的一种，也是唯一能够引入负超螺旋的拓扑异构酶。

The alteration of DNA gyrase and DNA topoisomerase IV is the main mechanism of resistance to fluoroquinolones in E. coli .

DNA促旋酶和拓扑异构酶Ⅳ的改变是大肠埃希菌对氟喹诺酮类耐药的主要机制。

DNA gyrase is an essential bacterial topoisomerase that catalyzes the ATP dependent negative supercoiling of double stranded closed circular DNA .

DNA回旋酶是细菌特有的一种拓扑异构酶，它能够利用ATP水解的能量将共价闭合环状DNA转变为负超螺旋DNA，从而维持细菌体内正常的超螺旋水平。

Objective To study the relationship between the gene mutations of DNA gyrase subunit A ( gyrA ) and quinolone resistance in Salmonella typhi .

目的研究伤寒杆菌DNA旋转酶A亚单位基因（gyrA）变异与其耐喹诺酮类的关系。

Fluoroquinolones , primarily by inhibiting bacterial DNA gyrase , so that bacteria can not engage in normal DNA replication and division , resulting in rapid bactericidal effect .

氟喹诺酮类药物主要通过抑制细菌的DNA旋转酶，使细菌不能进行正常DNA复制和分裂，从而产生快速杀菌作用。

The authors confirm their findings by showing that chemical or genetic prevention of gyrase inhibitor-induced oxidative damage protects from the bactericidal action of quinolone antibiotics .

使用化学或基因学的方法防止回旋酶抑制剂诱导的氧化损伤，即可对喹诺酮类抗生素的杀菌作用产生保护作用，研究者们由此证实了他们的发现。

Based on the homologous recombination , the plasmid pRG of reverse gyrase gene knock-out was constructed and transformed into the Sulfolobus islandicus and the single crossover mutant was isolated .

重组质粒反复转化冰岛硫化叶菌，得到质粒整合到宿主染色体上的单交换菌株，但没有获得反螺旋酶基因缺失的双交换转化子。

Among 41 predicted genes , 6 genes which encode terminase large subunit , including DNA Gyrase B subunit , peptidoglycan binding protein and 3 tail fiber proteins , were functionally known by analysis of bioinformatics .

在41个推定基因中，预测出编码DNA末端酶大亚单位、DNA解旋酶B亚单位、肽聚糖结合蛋白及3个尾丝蛋白等6个基因的功能。

Objective To study the relation between the alterations in the DNA gyrase subunit A ( GyrA ), topoisomerase ⅳ subunit C ( ParC ) and fluoroquinolones ( FQNL ) resistance in Klebsiella pneumoniae .

目的研究肺炎克雷伯菌DNA旋转酶A亚单位（GyrA）和拓扑异构酶ⅣC亚基（ParC）的变异与其耐氟喹诺酮类（FQNL）的关系。