glycan

The research of the glycan had already become a focus of the life science .

对糖进行研究已成为生命科学领域研究的热点。

Numerous diseases were known to relate with glycan structural abnormality .

许多疾病的发生与蛋白质糖链结构异常有关。

Purification and characterization carbohydrate - binding protein and glycan from marine organism

海洋生物中糖结合蛋白和聚糖的分离鉴定研究

If the difference is in glycan level , we can discuss the different site and the effect in physiology .

若此差异来自于醣基本身，则可进一步探讨其差异的位置，以及其背后是否具有生理意义。

Glycan Profiling of Rabbit Cells Detected with Lectin Array

应用凝集素芯片检测兔组织细胞膜表面糖谱

Glycan Profiling on the Cell Membrane of Normal Mucosal Epithelial Cells and Gastric Cancer Cells Detected with Lectin Array

应用凝集素芯片检测胃正常黏膜上皮细胞与胃癌细胞膜表面糖链表达

A long term goal is to establish a representative glycan library with sufficiently structural complexity and diversity to meet the demand .

长期目标是建立一个在分子结构上有足够复杂性与差异性，具代表性的寡醣分子储存库，以符合研究上的需求。

In recent years , studies have shown that the occurrence of disease followed with the change of glycoprotein glycan structure in salivary .

近年来有研究显示，疾病的发生涉及到了唾液糖蛋白糖链结构的改变。

Carbohydrate microarray could identify and characterize whole glycoprotein structures of intact cells , which is high-throughput technology for glycan analysis .

糖微阵列技术可以对生物个体产生的全部蛋白聚糖结构进行鉴定与表征，提高了聚糖分析通量。

My laboratory works are mainly focusing on the synthesis of biologically active oligosaccharides to support GRC glycan array research programs .

主要的研究工作在于合成各种具有生物活性的寡醣分子，来支援基因体中心有关醣晶片的研究课题。

Glycoconjugate glycan and its association with breast cancer

乳腺癌相关糖复合物糖链研究进展

A glycan protein complex ( GLM A ) was isolated from the Ganoderma lucidum with phosphate buffer solution at 80 ℃ .

用磷酸盐缓冲液在80℃时从灵芝菌丝体中提取出多糖-蛋白质缀合物LM-A。

The purpose of this experiment was integrating the principle of lectin to glycan binding affinity and high-throughput microarray technology to established lectin microarray .

本实验的目的在于尝试将凝集素结合糖蛋白糖链的特异性与芯片技术的高通量性、灵敏性结合起来建立凝集素芯片检测糖蛋白技术。

The current focus of the lab group 's work is glycan markers of prostate cancers and anti-glycan autoantibody signatures in prostate cancer patients .

当前，该团队的研究重点是前列腺肿瘤的糖标记以及该类肿瘤病人的抗糖分子的自身抗体。

Since large-scale synthesis of glycan is hard to accomplish both chemically and enzymatically , purification from natural resource becomes the efficient method of N-glycan preparation .

因糖苷不易以化学方法或者酶法大量合成，因此从自然界中分离天然的N-糖苷便成为获得N-糖苷的最有效的方式。

This approach can be further used in the detection of clinical samples . ( 2 ) The alteration of glycan structures is a universal hallmark of tumors .

为这一方法应用到临床样品的检测奠定了坚实的基础。（2）糖基化结构的变化是癌症中一种广泛的标志。

Glycomics is an emerging field of life science that proposed as a new concept to follow genomics and proteomics , which focus on glycan structures and function .

糖组学是继基因组学和蛋白质组学后的新兴研究领域，主要研究聚糖结构与功能。

Water-soluble coconut shell glycan and complexes of coconut shell glycan with copper (ⅱ) were prepared , and their antioxidant activity were also studied preliminarily .

探讨了从椰子壳中制备水溶性椰壳聚糖，进而制备椰壳聚糖-Cu（Ⅱ）配合物，并对其抗氧化活性做了初步研究。

Such as , the low yields of proteins , the difficulties of downstream processing , and the presence of non-authentic glycan structures on recombinant human proteins .

如蛋白产量低、下游加工困难、蛋白产品的异质性等等。

In order to explore the action in the biosynthesis of glycan , more than ten cDNA clones of different alpha-mannosidase have been isolated from yeast and mammalian cells .

为了研究其在聚糖生物合成中的作用，学者们已先后从酵母和多种哺乳动物细胞中克隆出了十多个不同的α-甘露糖苷酶的基因。

The α - mannosidase is a key enzyme of N - glycan synthesis and metabolism , which functions on removing the mannose reside of glycan .

α-甘露糖苷酶是一种参与糖蛋白合成和代谢的重要蛋白酶，它的功能是修剪N-聚糖中的甘露糖。

Water-coal-slurry additives can be prepared from certain compounds in the paper making black waste water such as lignine , organic acid and glycan substances by sulfonation , condensation and modification process .

利用造纸黑液中的木质素、有机酸和聚糖类化合物，在一定条件下进行磺化、缩合、改性制取质优价廉的水煤浆添加剂。

The generic name for polysaccharides is " glycan " homoglycansare composed of single monosaccharide ; for example , the D-glucans , cellulose and starch , release only D-glucose by hydrolysis .

多聚糖的俗名是“聚糖”。均聚糖由一种单糖构成。

Background and significance : Researches have shown that , in the infection process of influenza virus , the key element was the Hemagglutinin ( HA ) . In this process , HA specific binds with host cell by the glycan structure .

研究背景及意义：研究表明，流感病毒感染宿主的过程中，主要是通过血凝素（HA）与宿主细胞表面唾液酸糖链受体进行特异性的结合。

The glycosylated site was determined by comparison of peptide mapping before and after glycanase treatment . Tandem MS ( MS / MS ) was performed to analyze the structure of N linked glycan and deglycosylated peptide .

通过比较糖苷酶处理酶解肽段前后的肽谱，确定糖基化位点，并通过串联质谱（MS／MS）解析了Asn连接的糖型结构及去糖后肽段的氨基酸序列。

At present , the more determined drugs consist of steroid drugs , Ulinastatin , heparin and other glucosamine glycan , phosphodiesterase inhibitors such as Milrinone and Amrinone , anti-oxidants , and Sodium Nitroprusside and so on .

目前，较为确定的SIR治疗药物有：类固醇类药物、乌司他丁、肝素和其他葡萄糖胺聚糖、磷酸二酯酶抑制剂如米力农和氨力农、抗氧化剂以及硝普钠等。

The characteristics of glycan structure determine that they do not have UV absorption , and have lower response in the mass spectrometry than peptides . So the derivatization of glycan or enrichment of glycopeptides before MS analysis should be carried on in the analysis of glycosylation .

糖链结构本身的特点决定了其没有紫外吸收，在质谱中的响应信号强度远不如肽段。

Most often , monoclonal antibodies are isolated from mice immunized with the glycan of interest , but this process is laborious and most human glycans are not particularly immunogenic in mice , probably due to their conserved structures in these species , which gives rise to self-tolerance .

最常见的，用感兴趣的多糖免疫小鼠分离得到单克隆抗体，但这个过程费时费力，而且由于多糖保守结构带来的自身耐受性，大多数人源多糖对小鼠并不产生明显的免疫反应。