gck

Mutation of GCK gene of Chinese patients with late-onset Type 2 diabetes

中国迟发型2型糖尿病患者葡萄糖激酶基因突变研究

Conclusion There is a positive association on the microsatellite DNA marker of GCK gene with 2-DM .

结论葡萄糖激酶基因微卫星标记与2型糖尿病相关；

Study of Gene Mutation of GCK and HNF-1 α in MODY

GCK基因和HNF-1α基因突变的研究

Objective To investigate the prevalence of mutations and sequence variations of glucokinase gene GCK in Chinese early-onset diabetes population .

目的了解葡萄糖激酶（glucokinase）基因GCK突变和序列变异在中国人早发性糖尿病人群中的发生情况。

Silencing the GCK gene through RNAi can block the JNK pathway activated by LPS and UV .

而通过RNAi技术沉默gck基因可以阻断LPS和UV刺激活化JNK的信号通路。

Objective To evaluate the role of glucokinase ( GCK ) gene in the pathogenesis of gestational diabetes mellitus ( GDM ) in Chinese .

目的探讨葡萄糖激酶（GCK）基因与妊娠糖尿病（GDM）易感性的关系。

Conclusion : Th ere is no enough evidence to demonstrate that the variation in or near GCK gene is the major cause of diabetes in the family .

结论：GCK基因内或附近的基因变异不是本家系2型糖尿病的主要致病原因；

Objective To determine the mutation of the Glucokinase ( GCK ) gene in Chinese patients with Type 2 diabetes . Methods Forty-seven families with Type 2 diabetes were recruited .

目的：探讨中国迟发型2型糖尿病患者葡萄糖激酶（glucokinase，GCK）基因的突变情况。

The performances of the two algorithms are studied using network simulator ( ns-2 ), and the simulation results demonstrate the effectiveness of these two algorithms in terms of GCK renewal success ratio and delay .

利用网络模拟器ns-2，分析了算法的性能，模拟结果表明在多种移动自组网络条件下以上算法的更新成功率和更新延迟均具有较好的有效性。

The association of glucokinase ( GCK ) gene with type 2 diabetes in Chinese was studied by using the polymerase-chain-reaction amplified microsatellite polymorphism marker , GCK-5 ' .

应用聚合酶链锁反应扩增葡萄糖激酶（GCK）基因微卫星多态标志，GCK-5'，进行GCK基因与国人非胰岛素依赖型（Ⅱ型）糖尿病关联研究，并与非塘尿病组比较。

Object : To evaluate the roles of GCK gene and CTLA-4 gene in the pathogenesis of gestational diabetes mellitus ( GDM ), determine the risk factors and the obstetric complications of GDM .

目的：探讨GDM的危险因素和GDM患者的产科结果、葡萄糖激酶（GCK）基因与细胞毒性T淋巴细胞抗原（CTLA-4）基因与妊娠糖尿病（GDM）的关系。

Objective To investigate the variation of glucokinase ( GCK ) allele frequency in aged patients with type 2 diabetes mellitus ( DM2 ) and to provide a method for early detection of diabetes mellitus ( DM ) .

目的检测老年人2型糖尿病（DM2）患者葡萄糖激酶（GCK）等位基因频率的变化，进而从分子水平探讨DM及其血管并发症的发病机制。

There was no significant difference in allele and genotype frequency between GDM and control groups at the GCK 1 locus . For GCK 2 , four alleles ( 1,2,3,4 ) and eight genotypes were detected .

结果（1）GCK1的等位基因频率及基因型频率在两组间无差别。

The molecular scanning of the coding and junction regions of glucokinase gene ( GCK ) was performed in 30 Chinese subjects of common form non-insulin-dependent diabetes mellitus ( NIDDM ) with age of onset at or before 45 years , and / or with positive family history of diabetes .

对30例起病于45岁或以前及／或伴糖尿病家族史的中国人常见型非胰岛素依赖型糖尿病（NIDDM）患者，进行葡萄糖激酶基因（GCK）编码区及拼接区分子扫查。