fasn

There are two important enzymes related with the synthesis and release of fatty acids , Fatty Acid Synthase ( FASN ) and Lipoprotein Lipase ( LPL ), respectively .

与脂肪酸合成和释放有关的重要的两个脂肪酶，分别是脂肪酸合酶（FASN）和脂蛋白脂酶（LPL）。

Fatty acid synthase ( FASN ) is a key endogenous fatty acid synthesis enzyme , so in recent years studies on the expression of FASN in malignant tumors become one of the hotspot .

脂肪酸合成酶（FASN）是内源性脂肪酸合成的关键酶，因此近年来关于该酶在恶性肿瘤中的表达成为研究的热点之一。

FASN catalyzes the synthesis of long-chain fatty acids ( FA ) and LPL acts on plasma lipoproteins to hydrolyzing triglycerides and generate non-esterified fatty acids .

FASN催化合成长链脂肪酸（FA），LPL作用于血浆脂蛋白水解甘油三酯，并产生非酯化脂肪酸。

Consistent with a great demand for lipid synthesis , diverse human cancer cells express high levels of lipogenic enzymes , such as fatty acid synthase ( FASN ), the key rate-limiting enzyme in lipid biosynthesis .

人类多种癌细胞过度表达脂质生成酶，例如脂肪酸合成酶（FASN）、脂质生物合成过程中关键性的限速酶等。

In ovarian cancer , the expression level of FASN may be not related to patient age , tumor differentiation , lymph node metastasis and ascites cytology , but highly related to the clinical stages of the tumor . 3 .

在卵巢癌中，脂肪酸合成酶的表达可能与患者的年龄、肿瘤的分化程度、有无淋巴结转移及腹水细胞学检查无关，而与肿瘤的临床分期有关。

The expression of FASN mRNA in liver tissue of carp was higher and significantly ( P0.05 ) than that of the other tissues ; the graded tissue expression for FASN was : liver tissue brain tissue muscle tissue .

FASN基因的在鲤鱼肝组织中表达较高，显著高于其他组织（P0.05）；FASN在组织中表达高低顺序为：肝组织脑组织肌肉组织。

The expression level of FASN in normal ovarian tissue , benign , borderline and malignant tumors showed gradual upward trend , suggesting that the occurrence of ovarian cancer , development and invasion may be related to the expression level of FASN . 2 .

结论1.在卵巢正常组织、良性肿瘤、交界性肿瘤和恶性肿中，FASN的阳性表达率呈逐步上升趋势，提示卵巢癌的发生、发展、侵袭与FASN的过度表达可能有一定关系。

FASN can be used as an indicator of early diagnosis of ovarian cancer , one of which is to provide early diagnosis of ovarian cancer , a new basis , and the degree of malignancy of ovarian cancer in clinical analysis and monitoring of certain prognostic guide .

FASN可以作为卵巢癌的早期诊断指标之一，它为卵巢癌的早期诊断提供新的依据，并对卵巢癌的恶性程度的临床分析及预后的监测有一定指导作用。

FASN was not expressed in normal ovarian tissue , but largely expressed in benign ovarian tumors , borderline tumors and malignant tumors , and the positive expression rates were 15.4 % , 30.8 % , 67.1 % respectively , showing a gradual upward trend . 2 .

结果1.脂肪酸合成酶在正常卵巢组织中不表达，而在卵巢良性肿瘤、交界性肿瘤和恶性肿瘤中均有表达，其阳性表达率分别为15.4%、30.8%、67.1%，呈逐步上升趋势。