endosome

The Localization of Several Enzyme Activities on the Membrane of Endosome

几种酶在大鼠内吞体膜上的细胞化学定位

Endosome trafficking also regulated proteins activity by various ways such as modification and degradation .

同时内涵体转运也可以通过修饰和降解等方法调节蛋白的活性。

In eukaryotic cells , endosome trafficking is an important method to regulate the function of proteins .

内涵体转运是真核调节蛋白质功能的一个重要手段。

Objective : To investigate cytochemical localization of enzymes on the membrane of endosome in different organs .

目的研究多种酶在不同器官内吞体膜上的活性。

Sorting Nexins ( SNXs ) are new protein family associated with endosome sorting .

Sortingnexins（SNXs）是一个新的与内涵体分选相关蛋白家族。

Conclusion Endosome has complicated function and probably relates with cellular pH , the metabolism of water and salt , the metabolism of energy , protein and the production of active oxygen .

结论内吞体功能复杂，它可能与细胞的pH值，水盐代谢，能量、蛋白质的代谢以及活性氧的产生等都有一定的关系。

The function of domain II is to translocate the cleaved part of the toxin or other effectors from endosome to cytosol .

PE结构域Ⅱ的作用是使裂解后的毒素部分或其他效应分子从内吞体转位到细胞质。

Upon insulin binding to its receptor , the receptor ligand complexes will be internalized into the target cell . The internalized insulin will leave the endosome and associate with the nuclear matrix .

胰岛素与细胞膜上的胰岛素受体结合后，配体-受体复合物能被内吞入细胞，部分胰岛素与受体分离并进入细胞核。

At the cellular level , the disease is a result of improper trafficking of lipids such as cholesterol and glycosphingolipids ( GSLs ) to a late endosome / lysosome compartment .

其特征是患者细胞中胆固醇和鞘糖脂等脂类沉积在晚期胞内体/溶酶体中。

As a result , it is found that the enzyme activity Inside the matrix of lysosome can be inhibited by NaF , but insensitive to the enzyme activity on the lysosome and endosome membrane , the enzyme activity can be inhibited by NEM .

结果：溶酶体内的酶活性可被NaF所抑制，溶酶体和内吞体股上的酶活性则不能被NaF抑制，但能被NEM所抑制。