downregulation

However , the biological significance of such downregulation is not currently clear .

然而这种表达下调带来的生物学作用至今仍不清楚。

Shark Cartilage Preparation Induces Apoptosis of K562 Cells by Downregulation of Bcl-2 Expression

鲨鱼软骨制剂通过下调Bcl-2诱导K562细胞凋亡

Downregulation of PKA activity and the apoptosis of transitional cell carcinoma

蛋白激酶A活性下降对膀胱移行细胞癌凋亡的影响

Downregulation of Cellular Protein Annexin 2 Inhibits Replication of Classical Swine Fever Virus

宿主细胞膜联蛋白2下调表达抑制猪瘟病毒的复制

Cox proportional hazards model analysis suggested downregulation of p-catenin was an important factor indicating poor prognosis .

Cox风险模型分析提示β-catenin的表达下降是预后不良的重要指标之一。

Mechanism of downregulation of apoptosis by autophagy induced by oridonin in HeLa cells

冬凌草甲素通过诱导人宫颈癌HeLa细胞自噬下调凋亡的机制

Promoter methylation might be a main factor of glioma MGMT gene expression downregulation . 3 .

启动子区甲基化是人脑胶质瘤MGMT基因表达下调的主要原因。

Downregulation of gene expression in the ageing lens : A possible contributory factor in senile cataract

老化晶体的基因表达下调：发生老年性白内障的可能致病因素

Their downregulation can inhibit the development of cancer , therefore , both of them are ideal targets in cancer therapy .

它们的下调能够抑制肿瘤的发展，所以成为肿瘤治疗中的理想靶位。

Study on downregulation of c-myc and PCNA genes expression by antisense oligonucleotides in vascular smooth muscle cells

反义寡核苷酸阻遏血管平滑肌细胞c-myc，PCNA基因的表达

Downregulation of beta tropomyosin protein expression in colon adenocarcinoma

蛋白质组学检测β-原肌球蛋白在结肠癌组织中的表达

Downregulation of Bcl 2 expression appears to play an important role in the apoptosis of the differentiated leukemic cells .

bcl－2表达水平的降低可能是经诱导分化成熟的白血病细胞走向凋亡的重要条件。

INOS expression downregulation in TAA + RH group compared with TAA group ( p < 0.05 );

TAA+RH组iNOS表达较TAA组明显减少（P<0.05）；

Conclusions Apoptosis induced by Dex in CEM cells is associated with downregulation of the survivin expression .

结论地塞米松诱导CEM细胞凋亡与下调survivin基因表达有关。

Downregulation expressions of cathepsin B and cystatin C in diabetic nephropathy rats with cordyceps sinensis

冬虫夏草对糖尿病大鼠组织蛋白酶B及其抑制剂C表达的影响

The downregulation of specific T Lymphocyte responses by nasal administration of AChR in EAMG rats

鼻腔AChR耐受低调EAMG大鼠特异性T淋巴细胞反应

C-Myc Downregulation : A Critical Molecular Event in Resveratrol-induced Cell Cycle Arrest and Apoptosis of Human Medulloblastoma Cells

c-Myc表达下调是与髓母细胞瘤细胞周期阻滞和凋亡密切相关的分子事件

Selective COX-2 inhibitor could inhibit invasion of bladder cell line . The proposed mechanism was correlated with downregulation of MMP-9 .

选择性COX-2抑制剂可抑制膀胱癌细胞的体外侵袭，机制可能与其下调侵袭性蛋白酶MMP-9的表达有关。

Studies on the downregulation of gap - junctional in hepatocyte by microcystin-LR

微囊藻毒素-LR致肝细胞连接通讯下调的研究

Inhibitory Effect of Losartan on Monocytic Activation via Downregulation of Monocyte Chemoattractant Protein - 1 Receptor Expression

氯沙坦通过下调单核细胞趋化蛋白1受体表达抑制单核细胞活化

Resveratrol induces mitochondrial DNA repair enzyme downregulation and promotes pancreatic acinar cell apoptosis in rats with severe acute pancreatitis

白藜芦醇下调线粒体DNA修复酶对重症急性胰腺炎大鼠胰腺腺泡细胞凋亡的影响

Conclusion Downregulation of CGRP on the expression of P53 protein in ischemic neurons might promote the recovery of the ischemia neurons .

结论CGRP下调缺血神经元P53蛋白的表达，可能对缺血神经元的恢复有促进作用。

The effect of dexamethasone decrease retina cells apoptosis may relate to downregulation of the expression of c-FOS and caspase-1 .

而Dex抗凋亡作用可能与下调c-FOS和Caspase-1表达有关。

Downregulation of K14 Genes and Protein Expression by Liposome Conjugated Antisense Oligonucleotides in Keratinocytes

反义寡核苷酸阻遏角蛋白14的表达

Nine of 25 human colon cancers ( 36 % ) also showed downregulation of miR-34a compared with counterpart normal tissues .

在25例人结肠癌组织中，与癌旁组织相比其中有9例（36%）显示miR-34a的表达下调。

Downregulation of TGF - β receptors in epidermis of seborrheic keratosis

脂溢性角化病皮损的表皮中TGF-βⅠ型和Ⅱ型受体表达下调

Because of the downregulation of Topo ⅱ, most of chemotherapy drugs lose their targets to result in MDR .

肾癌TopoⅡ表达值显著降低，使大多数化疗药物丧失了作用靶点而产生MDR。

Elongator depletion results in the brain-specific downregulation of genes implicated in cell motility and migration .

Elongator复合物的消耗将导致与细胞能动性和细胞位移有关的基因的脑特异性下调表达。

The decreases in those important function molecules associated with antigen presentation , is suggestive of a downregulation of PAM antigen presentation .

MHC分子SLA-DR、抗原递呈途径中的重要伴侣分子SLA-DM和重要共刺激分子CD80与CD86等表达下调，表明PCV2感染猪的PAM抗原递呈功能减弱。

CONCLUSIONS : Dexamethasone-induced apoptosis in CEM cells is associated with downregulation of survivin expression , activation of caspase-3 .

结论DEX诱导CEM细胞凋亡时下调Survivin基因表达，活化Caspase-3。