death receptors

Death receptors can accept the death signals and activate the cell apoptosis mechanism .

死亡受体可以接受胞外的死亡信号而激活细胞内的凋亡机制。

Expressions of death receptors and decoy receptors of TRAIL in cervical carcinoma cells

宫颈癌细胞TRAIL死亡受体和诱骗受体表达的研究

Roles of death receptors in virus infection

肿瘤坏死因子受体超家族成员死亡受体在病毒感染中的作用

Most of death receptors in this pathway belong to the tumour necrosis factor receptor superfamily .

死亡途径中大多数死亡受体属于肿瘤坏死因子受体超家族。

Biology and Pathobiology of Death Receptors in Liver

肝脏中死亡受体的生物学和病理生物学作用

The inducible TRAIL and its death receptors expression induced by IFN - γ in RKO cell line

γ-干扰素诱导大肠癌细胞株肿瘤坏死因子相关凋亡诱导配体及其受体表达的研究

The mRNA expressions of death receptors in HeLa were significantly higher than those of decoy receptors ( P < 0.01 ) .

HeLa细胞表面DR4、DR5受体mRNA的表达明显高于DcR1、DcR2受体，差异有显著性（P<0.01），DR4、DR5受体之间及DcR1、DcR2受体之间表达差异无显著性（P>0.01）。

Although apoptosis can be induced by a wide number of stimuli and mechanisms , the hepatocyte is particularly susceptible to apoptosis by death receptors .

尽管有很多刺激和机制能够引起凋亡，肝细胞却特异性的对死亡受体引起的凋亡更易感。

While in the extrinsic pathway , the combination of ligands to the corresponding death receptors on the membrane activates caspase-8 .

而在外源性通路中，当死亡受体与相应的配体结合后激活caspase-8。

Activated T / NK cells exert their cytotoxicity on hepatocytes through inducing apoptosis intermediated by death receptors , resulting in liver injury .

激活的这两种淋巴细胞对肝细胞施展其细胞毒作用，通过引起由死亡受体介导的肝细胞凋亡过程来造成肝损伤。

Immunohistochemistry and FCM were used to detect the expression of TRAIL and its death receptors ( DR4 and DR5 ) .

免疫组化和流式细胞术检测肾脏TRAIL基因及其死亡受体DR4、DR5的蛋白表达。

The ability of inducing apoptosis by bunding death receptors on the tumor cells and it 's nontoxic to normal cells make TRAIL a potential chemotherapeutic drug .

TRAIL因为能和肿瘤细胞表面上的死亡受器结合而导致细胞凋亡，但对正常细胞的毒性甚低，所以近年来被研发成为抗肿瘤的药物。

TRAIL ( tumor necrosis factor-related apoptosis-inducing ligand ) is a member of the tumor necrosis factor family . After binding with its death receptors , the apoptosis signaling pathway is activated .

TRAIL（肿瘤坏死因子相关的凋亡诱导配体）属于肿瘤坏死因子超家族，在与死亡受体结合后，可启动凋亡信号的转导。

TRAIL induced apoptosis was positive correlation with the extent of inflammatory cells infiltration , but determined by the level of death receptors expression , ligand and receptor not a single one can be omitted . 5 .

TRAIL诱导的凋亡与炎症细胞浸润程度相关，但决定于死亡受体的表达水平，配体受体二者缺一不可。

So far , two different apoptotic pathways have been identified : the external pathway which is induced by the death receptors on cell surface , and the internal pathway which is induced by mitochondrial damage or ER stress .

到目前为止，已经确定了两条不同的细胞凋亡信号通路：由细胞表面的死亡受体介导的细胞凋亡外部信号通路；由线粒体损伤或内质网应激诱导的细胞凋亡内部信号通路。

The results showed that during death receptors including TNF - α or anti-Fas antibody induced hepatocytes apoptosis , Bax translocation and conformation change through activating Bid , which caused Bax to insert to mitochondria membrane of hepatocytes .

结果显示：TNFα或抗Fas抗体通过激活Bid导致Bax转位和构象变化，使Bax得以插入线粒体膜诱导肝细胞凋亡。

Apoptosis of T lymphocyte can be induced by death receptors such as Fas / FasL , Trail ( TNF related apoptosis inducing ligand ) / Trail receptor . Besides , mitochondria also plays a role in T lymphocyte apoptosis .

Fas/FasL、Trail/Trail受体等死亡受体信号传导可介导T淋巴细胞凋亡，线粒体在诱导细胞凋亡中也起着重要作用；

It is concluded that apoptosis plays an important role in cryoinjury of cord blood hematopoietic stem / progenitor cells , which triggers a mitochondrial apoptotic pathway that is caspase-dependent but does not require death receptors , where caspase-3 is the key effector .

结论：凋亡在脐血造血干细胞冷冻损伤中起着重要作用，其机制可能是通过线粒体介导的caspase依赖性途径执行，caspase3是其中一个重要的效应蛋白酶。

Death domain of receptors which initiates apoptosis

引发细胞凋亡受体的死亡结构域

FADD ( Fas-associated death domain protein ) and caspase-8 , especially , play an important role in many apoptotic pathways modulated by death receptors .

其中FADD和Caspase-8在多条死亡受体介导的凋亡途径中起着关键作用。Daxx则在基因转录和细胞凋亡两方面发挥重要作用。