ccnu

OBJECTIVE : To determine the CCNU concentration in blood and brain tissue .

目的：测定血液和脑组织中微量环己亚硝脲（CCNU）。

Conditioning regimens were TBI + Cy ( total body irradiation + cyclophosphamide ) or MAC + CCNU .

预处理方案为全身照射+环磷酰胺（TBI+CTX）或马法兰、阿糖胞苷、CTX和环己亚硝脲（MAC+CCNU）。

NO can also slow the degradation of CCNU in water solution .

同时NO能够缓解CCNU在水溶液里的降解。

After gamma knife radiotherapy all cases were given chemotherapy in CCNU .

全部病例治疗后均给予环己亚硝脲（CCNU）化疗。

The study result shows that the general sex psychological development of female college students at CCNU is positive and healthy ;

研究结果显示：华师女大学生性心理发展的主流是好的、健康的，大多数女大学生有正确的性观念。

Using COAP regimen and CCNU with FT-207 in the treatment of advanced non-small cell lung cancer

应用COAP方案及CCNU和FT-207治疗晚期非小细胞肺癌疗效观察

OBJECTIVE To prepare lomustine ( CCNU ) liposomes and study their pharmacokinetics in rats after intravenous administration .

目的研究洛莫司汀（CCNU）脂质体的制备方法并考察用聚乙二醇单甲醚（2000）胆固醇琥珀酸酯（PEGCHS）修饰前后的2种脂质体静脉给药后在大鼠体内的药动学。

RESULTS The entrapment efficiency of CCNU liposomes was above 80 % and the mean diameter was about 50 nm .

结果制备的洛莫司汀脂质体包封率高（>80%），平均粒径50nm左右；

CCNU co-cultured with SNAP for 24 h showed higher cytotoxic to BT-325 cells ( P < 0.05 ) .

3CCNU与SNAP共培养24h后，其对BT-325细胞的细胞毒作用比单用CCNU组明显增强（P<0.05）。

Conclusion : NO partly suppresses cytotoxicity of Lomustine , which might be associated with chemoresistance of BT-325 cells against CCNU in vitro .

结论：NO使BT-325细胞对CCNU的耐受性增强，从而部分抑制CCNU的细胞毒作用，这可能是CCNU耐药的一个新机制；

DETA NONOate suppressed cytotoxicity of CCNU to BT-325 cells in a dose-dependent manner ( P < 0.05 ) .

2DETANONOate能抑制CCNU对BT-325细胞的细胞毒作用（P<0.05），在一定程度内呈剂量效应关系。

Methods : CCNU was used to treat human glioma cell line BT-325 with different concentration of cytokines or NO donors , NO levels was measured by Griess assay and cell survival was evaluated by MTT assay .

方法：使用不同浓度的细胞因子或NO供体分别与CCNU作用于BT-325细胞，用Griess法测定NO浓度，MTT法测定实验处理后肿瘤细胞的生存率，以此观察NO对CCNU细胞毒作用的影响。

The results indicate that excellent linearity exists between concentration and absorbance of CCNU in blood and brain tissue . Measurable concentration ranges from 0.2-40 μ g / ml and 0 . 4-80 μ g / g , respectively .

结果显示：在血液及脑组织中，CCNU浓度与吸收度间线性相关良好，可测浓度范围分别为0.2～40μg/ml和40～80μg/g。

Conclusion : TMZ expressed more efficient object respond rate compared with CCNU and better clinical experience improvement with little relative toxicities . Although the six-month survival rate doesnot be thought to have statistical significance , but TMZ could improve effectively quality of life .

结论：TMZ比CCNU有较高的缓解率，更好的改善临床功能，伴随较少的相关毒性，虽然六个月存活率在本试验中未能判断为有意义的增加，但TMZ可有效的提高生活质量。

Autologous bone marrow transplantation ( ABMT ) was undertaker , in 7 cases of brain tumor , 48 hours after intensive chemotherapy ( CCNU 260-390mg / m2 ) . The average count of returned nuclear cells was 2.54 × 10 ~ 8 / kg .

本文介绍7例恶性脑瘤患者，给予大剂量环已亚硝脲（CCNU260～390mg/m~2）后48小时，进行自身骨髓移植，输入的有核细胞数平均为2.54×10~8/kg。