blys

Objective To obtain mammalian cell expression vector of human BLyS gene .

目的构建人BLyS基因真核细胞表达载体。

High Expression , Purification and Characterization of Human BLyS 78-285

人BLys78-285的高效表达、纯化及功能鉴定

Study on Expression and Clinical Significance of BLyS and APRIL in Multiple Myeloma

B淋巴细胞刺激因子及增殖诱导配体在多发性骨髓瘤中表达及临床意义的研究

Construction , Expression , Purification and Identification of the Function of BLyS Mutants

BLyS突变体的构建、表达、纯化和功能鉴定

With the increasing of concentration and effect time of BLyS , OD value increased gradually .

且随着BLyS浓度的增加、作用时间的延长，OD值逐渐增大。

CONCLUSION : Two phage display antagonist peptides of BLyS were obtained .

结论：获得了噬菌体呈现的能够抑制BLyS的两个短肽。

Construction and Biological Activity Analysis of Mutant BLyS Modified by T-helper Epitope

Th表位修饰的BLyS突变体的构建及活性分析

The overexpression of BlyS is a main reason for proliferation and chemotherapy resistance of B lymphoma cells .

研究发现，Blys的过表达是B淋巴瘤细胞快速增值及放化疗抵抗的重要原因。

B-lymphocyte stimulator ( BLyS ) is a new member of TNF family .

B淋巴细胞刺激因子（B-lymphocytestimulator，BLyS）是一种重要的肿瘤坏死因子（TNF）超家族成员。

BLyS can regulate proliferation and function of T and B lymphocyte by binding to its receptors .

它属Ⅱ型跨膜蛋白，通过与其受体结合而广泛参与T、B淋巴细胞增殖和功能的调节。

Expression of B Lymphocyte Stimulator ( BLyS ) from pET Plasmid Using Lactose as Inducer

乳糖诱导pET载体表达重组蛋白的研究

Animal experiment study shows that defective expression or over-expression of BLyS can lead to immune unbalance and induce various diseases .

动物实验证实，BLyS缺陷或过度表达均能引起机体的免疫失衡，诱发多种疾病。

Objective To screen and characterize an antagonistic peptide of B-lymphocyte stimulator ( BLyS ) .

目的筛选和鉴定B淋巴细胞刺激因子（BLyS）的抑制性小肽。

Objective To clone the cDNA at extracellular domain of human B-lymphocyte stimulator ( BlyS ) for high expression . purification and characterization .

目的克隆人B淋巴细胞刺激因子（B-lymphocytestimulator，BLyS）胞外区cDNA，并行高效表达、纯化及功能鉴定。

This article reviews the progress of Blys and its receptor about their molecular structure , biologic activity and their relationship with pathogenesy of B cell malignancies .

本文就Blys及其受体的分子结构、生物学活性及其与B细胞恶性肿瘤发病之间的关系的研究进展进行综述。

△ CT of BLyS in ANA 1 ∶ 100 group was 11.4 ± 0.9 , showing no significant difference from that of control ( P > 0.05 ) .

其中ANA1∶100组BLyS检测的△CT为11.4±0.9，与正常对照组比较，差异无统计学意义（P>0.05）；

Methods : Anti-human BlyS monoclonal antibody and biotinylated anti-human BlyS polyclonal antibody were used to detect serum BlyS levels by ELISA .

方法：以商品化的抗人BlyS单克隆抗体、生物素化抗人BlyS多克隆抗体，采用双抗夹心法自行建立BlyS血清水平的ELISA检测方法；

B lymphocyte stimulators ( Blys ) is a new member of tumor necrosis factor superfamily , which produces a marked effect through specific binding with three receptors .

B细胞刺激因子（Blys）是肿瘤坏死因子（TNF）超家族的新成员，通过与B细胞表面三个受体特异性结合而发挥作用。

Therefore , BlyS , its receptor or related antagonists may find medical utility in the treatment of B cell disorders associated with autoimmunity , neoplasia , or immunodeficiency syndromes .

因此，对BLyS及其受体的研究有助于阐明SLE等自身免疫疾病，BLyS、其可溶性受体和单克隆抗体有望开发为治疗自身免疫综合症的新型药物。

Recently , the research that BLyS is relevant to human immunologic diseases especially to B cell tumor formation and development is still in the starting stage . This kind of research has been becoming a new focus as the diagnosis and treatment of immunologic diseases .

目前关于BLyS与人免疫性疾病，尤其是与B细胞恶性肿瘤形成和发展关系的研究尚处于起步阶段，正成为其诊断和治疗研究的一个新热点。

Neutralization Antibodies Against the Binding of B Lymphocyte Stimulator ( BlyS ) and Its Recepter Panned by Phage Display from an scFv Antibody Library ; The Relation between LPB-ELISA Antibody Titers and Neutralization Antibody Titers of FMD

从噬菌体抗体库中淘选B淋巴细胞刺激因子（BlyS）的中和抗体口蹄疫LPB-ELISA抗体滴度和中和抗体滴度符合性研究