benzbromarone

Studies on the Quality of Benzbromarone and Its Impurities

苯溴马隆及其杂质的质量研究

Benzbromarone was synthesized from salicylaldehyde by condensation with chloroacetone , reduction , acylation , demethylation and bromination with 40.6 % overall yield .

以水杨醛为原料，经缩合、还原、酰化、脱甲基、溴化反应制得苯溴马隆，总收率40.6%。

Investigation of Benzbromarone in Management of Elderly Patients with Hyperuricemia

老年高尿酸血症患者立加利仙应用的探讨

Determination of Benzbromarone in human plasma by ion-pair HPLC

反相离子对HPLC法测定人血浆中苯溴马龙的浓度

Objective : To evaluate the efficacy and safety of domestic Benzbromarone in the treatment of hyperuricaemia .

目的：评价国产苯溴马龙胶囊治疗高尿酸血症的有效性与安全性。

A Randomized Controlled Study of Benzbromarone and Probenecid in the Treatment of Gout

苯溴马龙与磺丙舒治疗痛风的随机对照研究

Benzbromarone can be used in patients with mild to moderate renal insufficiency on a named patient basis but carries a small risk of hepatotoxicity .

苯溴马龙能用于轻中度肾功能不全的患者，但有引起肝毒性的轻度危险性。

Comparison group : oral Benzbromarone tablet , Once a day , one tablet for once ( 50mg ), serving a total of 2 weeks .

对照组：口服苯溴马龙片剂，每日1次，每次1片（50mg），共服2周。

Objective : To study the efficacy of the " Tong Feng ⅰ" capsule combined with Benzbromarone on chronic uric acid nephropathy ( CUAN ) .

目的：研究中药复方痛风Ⅰ号胶囊治疗慢性尿酸性肾病的临床疗效。

Results Benzbromarone decreased the yield of 4 ′ - hydroxytolbuta ￣ mide from 100 % to 14.5 % ;

结果CYP2C9抑制剂苯溴马隆抑制4′-羟基甲苯磺丁脲的生成，使其产率由100%下降到14.5%；

Conlusion : As same as Narcaricin mite , the domestic Benzbromarone is an effective and safe uricosuric medicine and is convenient to use .

结论：国产苯溴马龙胶囊是一强力排尿酸药，使用方便安全。

The structure , property , indication , side-effect and clinical evaluation of several bromine-contained medical products are introduced , i.e. bromhexine hydrochloride , ambroxol hydrochloride , benzbromarone and scopolamine butylbromide .

介绍几种含溴药品盐酸溴己新、盐酸氨溴索、苯溴马隆、丁溴东莨菪碱的结构和性质、适应证和副作用以及临床评价。

A HPLC method for the determination of benzbromarone tablets was established , using a Shim-pack CLC-ODS column with the mobile phase of methanol-water ( 80 ∶ 20 ), at the detection wavelength of 237 nm .

建立了苯溴马隆片含量测定的HPLC方法。以Shim-packclc-ODS为色谱柱，甲醇-水（80∶20）为流动相，检测波长为237nm。