antiplasmin

Kinetics Study on Antiplasmin Activity of Recombinant TFPI-2 in Vitro

重组TFPI-2抑制纤溶酶活性的酶促动力学实验方法研究

AIM : To prepare monoclonal antibodies ( mAbs ) against human plasmin α 2 antiplasmin complexes ( PAP ) .

目的：制备纤溶酶α2抗纤溶酶复合物（PAP）的单克隆抗体（mAb）。

CONCLUSION : The mAbs against PAP neoantigens with high affinity was acquired successfully , which provided a tool for determination of plasma levels of PAP without interferences from plasminogen and α 2 antiplasmin and for research on fibrinolytic status in vitro .

结论：成功地制备针对PAP新抗原的具有高亲和力的mAb，为建立不受其前体分子干扰的PAP特异性检测方法，研究纤溶系统的激活状态提供了工具。

Results Plasma tissue plasminogen activator activity and D dimer ( D D ) were significantly elevated at diagnosis , while the plasminogen ( PLG ), α 2 antiplasmin (α 2 PI ) and plasminogen activator inhibitor ( PAI ) activity decreased .

结果患者血浆组织纤溶酶原激活物活性、D-二聚体（D-D）水平显著升高；纤溶酶原活性（PLG）、α2抗纤溶酶活性（α2-PI）、纤溶酶原激活抑制物活性（PAI）水平降低；