Protein design

Structural Bioinformatics Based Protein Design

基于结构生物信息学的蛋白质设计

A new contact intensity function is given to consist with protein design research based on the relative entropy .

为了与基于相对熵方法的蛋白质设计工作进行统一，采用了新的接触强度函数。

Structure prediction and protein design are closely related .

蛋白质设计和蛋白质结构预测是紧密相关的。

A foundation for studying protein design using the HNP model and the relative entropy was made .

该工作为基于相对熵及HNP模型的蛋白质设计研究打下了基础。

Engineering novel small functional proteins by grafting active sites into small but stable proteins is an efficient protein design method .

将一个蛋白质的活性位点，嫁接到另一个分子量较小但是稳定的蛋白质（骨架蛋白）上，从而形成一种新的功能蛋白质，这是蛋白质设计中一种很有效的方法。

Structural bioinformatics based rational protein design will play important role in biological research and development of protein therapeutics in the post genome era .

利用结构生物信息学方法进行蛋白质的理性设计，将会在后基因组时代的生物学研究和蛋白药物开发中起到越来越重要的作用。

In order to overcome the difficulty of applying dual Monte Carlo method to the bigger molecule system and off-lattice model , a simple new method of protein design based on relative entropy is proposed .

为了克服双重蒙特卡罗方法用于较大分子体系及非格子模型的困难，提出了一个基于相对熵的蛋白质设计的简单方法。

It is an important issue in protein functional design .

特异性界面的设计是蛋白质功能性设计的主要问题之一。

Modeling Method of Loop for Protein Molecular Design

用于蛋白质分子设计的环区模建方法

We introduced local interaction optimization in protein functional design , which is to optimize every local interaction between the protein and the ligand .

我们这里采取另外一种策略，即优化蛋白质和小分子之间的每个局部相互作用。

Study of Linear Neutralizing Epitopes of Hepatitis E Virus Capsid Protein and Design and Construction of Epitope-based Vaccine

戊型肝炎病毒衣壳蛋白的线性中和性表位的研究及其一种表位疫苗的设计与构建

Methods : The protein molecule design included truncation at N_terminal , replacement of basic amino acid and reduction of the number of cysteine .

方法：分子改造包括以下内容：分子截短，突变碱性氨基酸，减少半胱氨酸的数目等。

In the studies of traditional drug development and biology , researchers always focus on a sole gene or protein target to design corresponding experiments , so they can not know overall interactions between drugs and organisms .

在传统药物研发和生物学的研究中，人们的思路往往是针对单个基因或者蛋白进行实验设计，因而无法从整体水平上把握药物与机体之间的相互作用。

Theoretical Study of Protein Folding and Protein Design Based on the Relative Entropy and Complex Network Methods

基于相对熵和复杂网络方法的蛋白质折叠与设计理论研究

The results show that the score function of complexes is effective and simple for rational protein docking and its design .

分于对接结果表明，此打分函数能有效并简单的应用于任意蛋白质分子对接。

Alternatively , investigators might analyze the three-dimensional structure of a protein domain and then design drugs that bind tightly to that region .

或者，研究人员也可以分析某个蛋白质区间的立体构造，设计出与该区间紧密结合的药物。

Protein-surface interaction is a common and complex phenomenon of nature . It has draw significant attention due to its important rold in many fields , such as protein conformational transition and design of biomaterials .

蛋白质与表面之间的相互作用是自然界一个普遍而又复杂的现象，理解其作用机制在探索蛋白质的构象变化机制以及生物材料的设计等方面具有重要的意义。

It plays a very important role in gene discovery , genetic diagnosis of diseases , prediction of protein structure , drug design based on molecular structure , drug synthesis and pharmaceutical industry . The application of bioinformatics has greatly quickened the speed of drug exploitation .

生物信息学在基因发现、疾病基因诊断、蛋白质结构预测、基于结构的药物设计、药物合成和制药工业中起着极其重要的作用，生物信息学的应用大大加快了药物的研究开发进程。

Research of protein folding becomes the core subject related to protein design and molecular biology .

蛋白质折叠相关研究对蛋白质设计、疾病成因等方面研究有决定作用，已经成为众多相关学科研究中的核心问题。

Understanding this mechanism would greatly accelerate our study on the protein self-assembling , and moreover , be helpful to protein design and to the treatment of various diseases relevant to protein misfolding ( such as mad cow disease and Alzheimer disease ) .

了解该机制将加深我们对蛋白质自组装过程的认识，进而为治疗各种蛋白质折叠病（如疯牛病和老年痴呆症）提供帮助，为蛋白质分子设计提供指导。

CONCLUSION : High expression of SCF - TPO fusion protein has been obtained and protein prediction shows that the fusion protein design is reasonable , which lay foundation for further study of biological fundation of SCF - TPO fusion protein .

结论：获得了SCF-TPO融合蛋白的高表达，结构预测融合蛋白的设计符合要求。为进一步研究SCF-TPO融合蛋白的生物学特性奠定了基础。

The development of protein therapeutics and research of protein interaction networks require selective protein inhibitors and design of function and property of proteins .

对蛋白质及其相互作用等网络的进一步深入研究将会有越来越多对特异性蛋白抑制剂以及蛋白质功能和特性进行改造的需求；

Although researches on the protein structures got more and more attention because they are the foundation of the function research and protein design , the experiment of protein structural determination is quite time - and money-consuming and of limited success rate .

所以蛋白质结构的研究是功能研究和蛋白质设计的基础，也因此越来越得到重视。蛋白质种类繁多，结构千差万别，同时蛋白质结构测定实验是非常费时费力，消耗资源也大，而且成功率有限。

The protein folding problem has two components : the direct folding problem ( i.e. folding ) and the inverse problem ( i.e. protein design ) .

蛋白质折叠问题包含两个方面的内容：正折叠问题（称为蛋白质折叠）和逆折叠问题（即蛋白质设计）。