PRPC

Effects of PI3K / Akt signaling pathway on PrPc induced drug resistance in gastric cancer

PI3K/Akt途径在朊蛋白介导胃癌耐药中的作用研究

There was certain relation between the nonconservative residues of PrPC sequence and species barrier ;

PrPC蛋白质序列中非保守残基与种间屏障有一定关系；

PrPc may be associated with keeping the function of nervous system and protect neuron from oxidative stress by its antioxidant function ;

通过抗氧化途径而保护神经系统细胞免受氧化损伤；

The distribution pattern of binding proteins for PrPc is similar with that of PrPc in brain .

朊蛋白与其受体在脑组织中分布相似。

PrPc was not detected in lung .

在肺脏中未检测到表达。

The studies about PrPc include its brain localization and putative physiological functions and the identification of its receptors ( binding candidates ) .

目前己有的关于细胞型肮蛋白的研究包括蛋白在正常脑内的分介、生理功能以及对其受体（或结合蛋白）的确定。

The PrPc gene was amplified by polymerase chain reaction , using two primers . It was then cloned into pGEM-T Easy Vector .

用所设计引物以聚合酶链式反应扩增出不致病的朊病毒蛋白（PrP~c）基因，并克隆到pGEM-Teasyvector。

PrPc is expressed most abundantly in the brain , but has also been detected in other non-neuronal tissues such as muscle , lymphoid tissues and skin .

PrPc在大脑组织中表达最为丰富，在许多非神经组织包括肌肉、淋巴组织和皮肤中也有表达。

The normal , cellular prion protein , designated PrPc , is a glycosylphosphatidylinositol ( GPI ) - anchored membrane protein that is highly conserved in mammalian species .

朊病毒是Prion病的病原体，朊蛋白（PrPc）是朊病毒在细胞内的正常表现形式，它以GPI锚定的方式定位在细胞膜上，在各物种间高度保守。

It is composed of scrapie form of the prion protein ( PrPSc ) which was converted by the misfolding of cellular form of prion protein ( PrPC ) .

它是由正常形式的蛋白（PrPC）错误折叠成致病蛋白（PrPSc）而组成的。

07 . Furthermore , sequences analysis also demonstrate that these two PrPC bear the structural signatures of PrP including a signal sequence , basic structure , tandem repeats , a hydrophobic region , a glycosylation site , a disulphide bridge and a glycosylphosphatidylinositol anchor site .

它们具有PrPC蛋白的典型特征：信号肽、基本结构、重复肽区域、疏水区域、二硫键、糖基化位点和一个糖基缩醛磷肌醇位点（GPI）。