Neurofibrillary tangles

The CAA was often accompanied with the senile plaques and neurofibrillary tangles .

CAA往往同时伴有老年斑和神经原纤维缠结。

Alzheimer 's disease ( AD ) is the most common form of dementia , the pathological features of AD include neuritic plaques composed of beta-amyloid protein , neurofibrillary tangles .

阿尔茨海默病（AD）是引起痴呆的最常见类型之一，其主要病理改变包括由β-淀粉样蛋白构成的老年斑、神经原纤维缠结。

Effect of Dephosphorylation on the Structure and Function of Alzheimer Neurofibrillary Tangles

去磷酸化对Alzheimer神经原纤维缠结结构和功能的影响

The main component of neurofibrillary tangles is the abnormal phosphorylated tau protein .

其中，神经原纤维缠结的主要成分是异常磷酸化的tau蛋白。

In the past three decades , neurofibrillary tangles hypothesis is one of the focuses of AD pathogenesis research .

近二三十年以来，神经元纤维缠结学说是AD发病机制的研究热点之一。

Segmentation of senile plaques and neurofibrillary tangles is crucial to pathological analysis of Alzheimer 's disease .

老年斑和神经元缠结的分割提取对于阿尔茨海默症病理研究有重要的意义。

Neurofibrillary tangles in ALS and parkinsonism-dementia complex focus in Kii , Japan

ALS和帕金森痴呆症中的神经元纤维缠结现象重点在日本纪伊

Observed the neurofibrillary tangles by silver stain and count the number of neuron and neurofibrillary tangles .

浸银染色观察神经元纤维缠结并计数单位面积中神经元和神经元纤维缠结的数目；

Eventually , brain cells are lost , and there is accumulation of abnormal peptides in plaques , as well as neurofibrillary tangles .

最终，脑细胞会丢失，并且存在异常肽聚集板块以及神经纤维团。

Results CR2 was detected in senile plaques and neurofibrillary tangles of the hippocampus and the temporal isocortex in AD brain tissues .

结果AD患者海马、颞叶脑组织中的特异性病变组织老年斑和神经纤维缠结有CR2表达。（2）神经纤维缠结；

Firstly , a modified fuzzy C means method is used on the RGB color space to identify senile plaques and neurofibrillary tangles in microscopic image of the hippocampus separately .

利用改进的模糊C均值算法对彩色图像的颜色信息进行聚类，分别提取了老年斑和神经元纤维缠结目标。

The mainly pathological changes in AD included senile plaque formed with A β deposition , neurofibrillary tangles ( NFTs ), synapses loss and neural cell death .

AD的病理变化主要是β淀粉样蛋白（Aβ）沉积造成的老年斑、神经纤维缠结、突触丢失和神经元死亡。

The rest of the disease process , including formation of neurofibrillary tangles containing tau protein , is thought to result from an imbalance between A β production and A β clearance .

AD的其它病理过程包括含tau蛋白的神经纤维缠结的形成等均被认为是由于Aβ的生成与清除之间发生失衡引起的。

Its main neuropathological features include diffuse loss of neurons in the hippocampus and neocortex , neurofibrillary tangles , accumulation of extracellular amyloid or senile plaques .

AD的神经病理表现主要是海马区和新皮质区弥散性的神经元丢失、神经纤维缠结和细胞外的类淀粉样沉积。

Neuritic plaques ( NPs ) and neurofibrillary tangles ( NFTs ) are the two most characteristic pathologic hallmarks of AD.

神经炎性斑块和神经纤维缠结是AD主要的病理学特征。

Interleukin-1 can also lead to the formation of neurofibrillary tangles and facilitating neurite outgrowth , etc , and then participate in the whole pathophysiological processes of Alzheimer disease .

白细胞介素1还可导致神经元纤维缠结形成、促进轴突增生过长等，从而参与整个阿尔茨海默病的病理生理过程。

The characteristic change of pathology in AD were neuritic plaques ( NP ), neurofibrillary tangles ( NFTs ) and the loss of cholinergic neuron .

主要的病理改变为神经炎斑，神经纤维缠结，胆碱能神经元丢失等。

The main histopathological hallmarks of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles ( NFTs ) in brain cortex , and decrease of brain cortex cells .

AD的特征性病理学改变为大脑皮质神经细胞内神经原纤维缠结、细胞外大量老年斑形成和大脑皮质细胞减少。

Conclusion Axonal leakage might be a key neuropathological change , and probably lead to the formation of plaques and neurofibrillary tangles , and may also play a causative role in the cognitive deficit in AD.

结论轴突漏可能是AD关键性的神经病理改变，不但可能导致斑块的产生和神经原纤维缠结的形成，而且可能是AD认知障碍的主要原因。

OBJECTIVE : Alzheimer 's disease is characterized by the formation of two main protein aggregates : senile plaques and neurofibrillary tangles , which are involved in the process leading to progressive neuronal degeneration and death .

目的：阿尔茨海默病的两大病理特征是老年斑与神经原纤维缠结，这两种病变可导致渐进的神经元变性并与神经元死亡有关。

Neurofibrillary tangles are closely correlated to abnormal hyperphosphorylation and glycosylation of tau protein , thus the role of tau protein in the development of AD has been a focus in the current study of AD.

由于以磷酸化和糖基化为主的Tau蛋白异常翻译后修饰与神经元纤维缠结关系密切，因此，关于Tau蛋白在AD发生发展中的作用已成为近年AD研究领域的一大热点。

Alzheimer 's disease ( AD ) is a neurodegenerative disorder characterized by the progressive loss of cognitive ability , neuropathological senile plaque , neurofibrillary tangles , and neuronal loss in selective brain regions .

阿尔茨海默氏病（Alzheimer'SDisease，AD）是一种以认知障碍和记忆力损害为特征的中枢神经进行性退行性疾病。

Toxications of the central nerve system include impairment of learning and memory , neurofibrillary tangles ( NFTs ) in different brain tissues , increasingly gathered aluminum in the brain and the functional decrease of the central cholinergic nerve .

其对中枢神经系统的毒性作用可引起学习记忆障碍，引起脑内多种组织出现神经纤维缠结，且脑组织铝含量明显升高，同时脑内胆碱能神经功能明显降低。

Results A new neuropathological change - " axonal leakage " in the brains of AD patients was identified , which was accompanied by swellings of varicosities and axons , and was related to the degree of senile plaques and neurofibrillary tangles .

结果AD患者脑出现重要的神经病理改变轴突漏（axonalleakage）。轴突漏常伴随肿胀的轴突和轴突膨体，且与传统的神经病理改变斑块和神经原纤维缠结有明显的相关性。

RESULTS : Senile plaques , neurofibrillary tangles and neuronal death , in which free radicals are all involved , represent the three pathological features of Alzheimer disease . Therefore , the application of ectogenous antioxidant is a potential method for the drug treatment of Alzheimer disease .

结果：阿尔茨海默病3种主要病理变化-老年斑、神经纤维缠结、神经元死亡都有自由基参与，因此外源性抗氧化剂的应用是阿尔茨海默病药物治疗的有前途的一种方法。

Alzheimer 's disease ( AD ) is the most common age-related neurodegenerative disorder . The characteristic pathological lesions are deposits of β - amyloid plaques and neurofibrillary tangles after postmortem examination , and degeneration of cholinergic neurons of the basal forebrain .

阿尔茨海默病（AD）是一种退行性神经功能障碍性疾病，其典型病理学特征是β-淀粉样蛋白斑块、神经纤维缠结和基底前脑乙酰胆碱能损害。

Cytoskeletal abnormality has been observed in a variety of neurodegenerative diseases , among many of these diseases , tau protein related pathological changes are often observed , such as the neurofibrillary tangles in Alzheimer disease , suggesting the correlation between chronic stress and tau protein abnormality .

多种神经系统退行性疾病中都出现了细胞骨架的异常。其中许多疾病出现了tau蛋白相关的病理改变，如AD中的神经原纤维缠结，提示慢性应激与tau蛋白异常之间存在相关性。

In Non-gmo models most only simulate a certain aspect of AD pathology characteristics , while the pathological process of AD is complex , various , and do not present the AD typical characteristic in the brain : senile plaques ( SP ) and neurofibrillary tangles ( NFTs ) .

非转基因模型中，大部分模型只针对AD病理特征的某一个方面，而AD的病理过程是复杂的多方面的，且不呈现AD脑内特征性改变：SP和NFTs。