Molecular targeted therapy

Clinical Application and Evaluation for Molecular Targeted Therapy of Breast Cancer

乳腺癌分子靶向治疗的临床应用及其评价

Treatment Based on Syndrome Differentiation and Molecular Targeted Therapy of Cancer

论中医的辨证论治与肿瘤的分子靶向治疗

Development of molecular targeted therapy of pancreatic cancer

胰腺癌分子靶向治疗研究进展

Objective : Molecular targeted therapy has achieved outstanding results in clinical cancer treatment practice in recent years .

目的：分子靶向治疗在近年的临床肿瘤治疗实践中取得了突出的成效。

Advances of Molecular Targeted Therapy for Malignant Gliomas

恶性脑胶质瘤分子靶向治疗研究进展

Compared with traditional chemotherapy , molecular targeted therapy have highly selectivity , low toxicity and high therapeutic index .

实践已证明分子靶向治疗具有高选择性、低毒性和高治疗指数，可长期用药。

Molecular targeted therapy has limited or nonexistent side effects on normal cells of the body , unlike traditional chemotherapy .

分子靶向治疗比传统的化疗特异性强、毒副反应小，将成为今后肿瘤治疗的新趋势。

To date , Molecular Targeted Therapy , which targets the characteristic changes of tumor cells , has increasingly attracted attention .

近年来，以肿瘤细胞的特性改变为作用靶点的分子靶向治疗（Moleculartargetedtherapy）日益受到密切关注。

Molecular targeted therapy is a highlights in recent research , but there are not satisfactory results in the treatment of pancreatic cancer .

分子靶向治疗是近年研究的亮点，但在胰腺癌治疗中无令人满意的成果。

Radionuclide therapy , and radiotherapy , chemotherapy , endocrine therapy , molecular targeted therapy , thermotherapy method .

还有放疗、放射性核素治疗、化疗、内分泌治疗、分子靶向治疗、热疗等方法。

So , a new method , which is called as molecular targeted therapy , begins to be valued to improve these shortcomings .

针对以上这些缺点，一种新的治疗方法开始被大家所重视，这就是分子靶向治疗。

For patients who are inoperable and in the advanced stage , chemotherapy combined with molecular targeted therapy can have better therapeutic effect .

对晚期不能手术的患者采用先化疗后分子靶向治疗的续贯疗法可取得较好的疗效。

In this review , we discuss the current advances in combined management of metastatic colorectal cancer of 5-Fu , chemotherapy , Molecular targeted therapy .

本文将对5-FU、新一代化疗药物以及分子靶向药物在转移性结肠癌治疗的演进及新进展作一综述。

Background : Hepatocellular carcinoma ( HCC ) is a common malignant tumor in China , the early diagnosis and molecular targeted therapy has become research hotspot .

背景：肝细胞癌（Hepatocellularcarcinoma，HCC）是我国常见的恶性肿瘤之一，目前针对其早期诊断及分子靶向治疗的研究日渐成为研究中的热点。

With the development of Immunology and depth study of the mechanism of cancer initiation , the treatment in cancer goes into the times of molecular targeted therapy .

随着免疫学及分子生物学的进展和对肿瘤发病机制的深入研究，肿瘤治疗进入了分子靶向治疗时代。

Molecular targeted therapy has a advance development , the molecular targeted therapies drug for epidermal growth factor receptor ( EGFR ) present definite clinic effect .

肺癌分子靶向治疗近年来取得较大进展，特别是针对表皮生长因子受体（EGFR）分子靶向药物表现出确定的临床效果。

Current treatment of lung carcinoma including surgery , radiotherapy , chemotherapy and molecuLar targeted therapy is still unsatisfactory , the survival of patient without a breakthrough .

肿癌现有的治疗手段包括手术、放化疗和分子靶向治疗仍不尽人意，患者生存期无突破。

In recent years , studies about molecular targeted therapy with unique curative effect and high safety have been to be the hotpot in the research of medical treatment of tumor .

近年来，分子靶向治疗因其具有疗效独特和安全性高等特点而成为肿瘤研究的热点和主流方向。

In order to elevate the availability of molecular targeted therapy in ovarian cancer , it is important to analyze ovarian malignant phenotype gene correctly and select the best candidate medicine targets .

为提高卵巢癌分子靶向治疗的有效性，关键在于准确分析卵巢癌恶性表型基因并选择最佳候选药靶。

KRAS mutation frequency in tumor tissue , can be predicted non-small cell lung cancer molecular targeted therapy efficacy and prognosis , and molecular inhibitors of RAS genes is still in its infancy .

KRAS基因突变在恶性肿瘤组织中频发，可预测非小细胞肺癌分子靶向治疗的疗效和预后，针对RAS基因的分子抑制剂研究仍处于初级阶段。

Conclusion : intensity modulated radiation therapy combined with molecular targeted therapy can improve the local symptoms of patients with locally recurrent nasopharyngeal carcinoma , the recent results are satisfactory and adverse reaction can be tolerated .

结论：调强放疗联合分子靶向治疗可改善局部复发鼻咽癌患者的局部症状，近期疗效满意，毒副反应可耐受。

Generally , the traditional pathological type and clinical stage cannot be used to guide endocrine therapy and molecular targeted therapy because of their limitations in reflecting the expressions of ER , PR and HER-2 gene .

传统的病理分型和临床分期因其不能很好地反映出这些受体蛋白的表达状况，难以对内分泌和分子靶向治疗起到有效指导。

Objective : Investigate the clinical features and treatment of locally recurrent nasopharyngeal carcinoma , and the efficacy and safety of intensity modulated radiation therapy combined with cetuximab molecular targeted therapy for locally recurrent nasopharyngeal carcinoma .

目的：探讨局部复发鼻咽癌的临床特点、治疗方法以及调强放疗联合爱必妥治疗局部复发鼻咽癌的疗效和安全性。

The treatment of gastrointestinal stromal tumors ( GIST ) has been revolutionized by the molecular targeted therapy , but we still emphasize the importance of how to use surgical principle and skill to treat GIST .

靶向治疗的问世使得胃肠间质瘤（GIST）的治疗发生了革命性的变化，但依然应强调外科原则和技巧在治疗GIST中的重要性。

Although many application of treatment methods for refractory or relapse non-hodgkin lymphoma , such as allogenic stem cell transplantation , molecular targeted therapy and so on , had been appeared , but the consensus among different international communities has not been accepted .

对于这些复发或难治的患者多项研究应用各种治疗方法，如造血干细胞移植、联合化疗治疗、分子靶向治疗等，但目前由于技术及供者的限制，仍未得到统一共识。

Progress of study on nano-scale contrast agents for ultrasonic molecular imaging and targeted therapy

纳米级造影剂在超声分子显像与靶向治疗中的研究进展

C-met is involved in regulation of cell growth and apoptosis in many tumor cells and can be one of molecular targets in targeted therapy of cancer treatment .

c-met参与调节多种肿瘤细胞的增殖和凋亡，是恶性肿瘤靶向治疗的靶点之一。

In recent years , with the progression of medical molecular biology , targeted therapy aimed at the molecular events of lung cancer has been a focus of research .

近年来，随着医学分子生物学技术和理论的进展，针对肺癌发病的分子事件的靶向治疗备受关注。

In recent years , with the best understanding of the carcinogenesis and the development of molecular biotechnology , endocrine therapy and molecular targeted therapy are used widely because of their high specificity and low side effects .

近年来，随着乳腺癌发病机制研究的深入和分子生物学技术的进步，内分泌治疗和分子靶向治疗因其特异性较高和不良反应相对较低受到越来越多的重视。