MHC restriction

The MHC restriction of T cell is determined in positive selection .

胸腺细胞的发育要经历阳性选择和阴性选择。

Discovery of MHC Restriction in Antigen Recognition of T Cells

T细胞抗原识别MHC限制的发现

Structural Characteristic and MHC Restriction of Polypeptide Sequence

多肽序列的结构特征与其MHC限制性

The MHC restriction of T cell is determined in positive selection . The tolerance of T cells to autoantigen is acquired during negative selection .

阳性选择决定了成熟T细胞的MHC限制性，阴性选择使机体获得自身免疫耐受。

T cell can only recognize specific antigenic peptide-MHC complex on antigen-presenting cell . This is MHC restriction in antigen recognition of T cell .

T细胞只能识别抗原提呈细胞表面特定的抗原肽MHC分子复合物，这就是T细胞抗原识别的MHC限制。

Gene vaccines have many advantages , such as the simplicity of preparation , the long time of immune stimulation and no considering the MHC restriction . Many achievements have been obtained using gene vaccines .

基因疫苗有许多优越性，如制备简便、免疫效应时间长、不必考虑MHC限制性问题等，并已经在很多领域包括肿瘤等疾病的防治中取得了巨大进展。

Because of complexity of the parasite 's life cycle , stage specificity and variation of the antigen and host MHC restriction , an effective malaria vaccine in principle should be composed of multiple antigens derived from different stage of the parasite to generate a multistage , multivalent vaccine .

由于疟原虫的生活史复杂、抗原具有期特异性和变异性以及宿主MHC限制性，一个有效的疟疾疫苗应由多期多种抗原组成。