Integrase

Different from protease and reverse transcriptase , the integrase has no counterpart in mammalian body , thus it has a better selectivity .

这是因为与蛋白酶和逆转录酶不同，整合酶在哺乳动物体内没有同源蛋白，因此有着更好的选择性。

Construction and expression of human anti HIV 1 integrase single chain antibody gene

人源抗HIV-1整合酶单链抗体基因的构建及表达

Detection of HIV-1 Integrase in vitro Activities using Fluorescent Technology

用荧光方法检测HIV-1整合酶的体外活性

The Research Status of Integrase Inhibitors for Human Immunodeficiency Virus

人免疫缺陷病毒整合酶抑制剂的研究现状

Rational design of HIV-1 integrase inhibitors using a de novo drug design method

用从头药物设计方法合理设计HIV-1整合酶抑制剂

Prokaryotic Soluble Expression and Functional Study of HIV-1 Integrase Protein

HIV-1整合酶蛋白的可溶性表达及功能研究

Structure-Based Design of HIV-1 Integrase Inhibitors : A Computer Modeling Approach

基于结构的HIV-1整合酶抑制剂设计：计算机模拟方法

Chemical Biology Directed Discovery and Structural Optimization of HIV-1 Integrase Inhibitors

化学生物学导向的HIV-1整合酶抑制剂的发现和结构优化

The oral drug is the first in an HIV drug class called integrase inhibitors .

这种新型的口服抗艾滋病毒药物属于整合酶抑制剂。

MIA test showed the three compounds had inhibitory activities against HIV-1 integrase .

活性筛选结果表明，寡聚缩合鞣质具有抗HIV1整合酶的活性。

According to the kinds of integrase , there are main four kinds of integrons .

根据整合酶不同进行分类，整合子主要分为Ⅰ～Ⅳ类。

The Methods for Screening HIV Integrase Inhibitors in vitro

HIV整合酶抑制剂体外筛选方法研究进展

The positive ratio of class 1 integrase gene was 80 % ( 48 / 60 ) .

整合酶intI1基因阳性率为80%（48/60）；

A study of class I integrase gene related antibiotic resistance in continuously isolated Pseudomonas aeruginosa strains

铜绿假单孢菌连续分离株耐药性与Ⅰ类整合酶基因的研究

Modeling the Tetrameric Structure and Its Active Sites of HIV-1 Integrase

HIV-1整合酶四聚体结构模拟及其活性位点分析

Class ⅰ,ⅱ and ⅲ integrons were detected by integrase gene PCR .

整合酶基因扩增法检测Ⅰ类、Ⅱ类和Ⅲ类整合子；

Study on the Interactions between HIV-1 Integrase with Inhibitors and Viral DNA with Molecular Simulation Approaches

用分子模拟方法研究HIV-1整合酶与抑制剂及病毒DNA的相互作用

Research progress on HIV-1 integrase and its inhibitors

Ⅰ型人类免疫缺陷病毒整合酶及其抑制剂研究进展

Molecular Dynamics Simulation on the Complex of HIV-1 Integrase and the Inhibitor Aurintricarboxylic Acid

HIV-1整合酶与抑制剂金精三羧酸复合物的分子动力学模拟

Prediction of the Interaction of HIV-1 Integrase and Inhibitor Aurintricarboxylic Acid Using Docking

用分子对接方法预测HIV-1整合酶与金精三羧酸抑制剂的相互作用

On the basis of integrase amino acid sequence similarity , integrons are divided into five classes .

整合子根据整合酶基因序列的不同通常分为五类。

Studies on the inhibition of polyhydroxylated aromatic compounds against HIV-1 integrase

多羟基芳香族化合物对HIV-1整合酶的抑制作用多羟基黄酮醇类化合物的合成

Analysis the relationship between structure and function of the Φ C31 integrase is the basis and key for solving above problems .

而解析ΦC31位点特异性整合酶结构与功能关系是解决上述问题的基础和关键。

Aim To synthesize a series of new caffeic acid derivatives and test their HIV-1 integrase inhibitory activities .

目的合成新型咖啡酸衍生物并测定其抑制HIV1整合酶活性。

Objective : Preparation of recombinant phage ScFv against HIV 1 integrase ( IN ) .

目的：研制HIV－1整合酶（integrase，IN）的重组噬菌体单链抗体。

Study on the gene of aminoglycoside-modifying enzymes and type ⅰ integrase from Klebsiella pneumoniae in elderly

肺炎克雷伯菌老年人分离株氨基糖苷类修饰酶和Ⅰ类整合酶基因研究

Two are " integrase inhibitors " that block the HIV genetic material from attaching to the host cell 's DNA .

其中两种药物是“整合酶抑制剂”，它可以阻止艾滋病病毒的遗传物质附加到宿主细胞的DNA中。

A preliminary study on single chain fragments variable ( ScFv ) antibody against HIV 1 integrase by phage surface displaying

利用噬菌体表面呈现技术制备HIV-1整合酶单链抗体的初步研究

Purification and Assays for Activities of HIV-1 Integrase

HIV-1整合酶的纯化及活性检测

The Structural Investigation of the HIV-1 Integrase Holoenzyme and the Screening of Its Inhibitors

HIV-1整合酶全酶结构模拟及其抑制剂筛选