HDAC

Structure based virtual screening of HDAC inhibitors

基于结构的组蛋白去乙酰化酶抑制剂虚拟筛选

Studies have shown that , HDAC inhibitors can mediate the differentiation of several cells through inhibited the activity of HDAC .

有研究表明，去乙酰化酶（HDAC）抑制剂通过阻断HDAC活性可以介导多种细胞的分化。

HDAC inhibitors could reverse these abnormalities and impose anti-leukemia ability .

使用HDAC抑制剂可以逆转这两种蛋白的异常功能，达到治疗白血病的目的。

Relationship between HDAC activity and lung function as well as smoking in peripheral blood mononuclear cells of COPD patients

COPD患者外周血单核细胞中HDAC活性及其与肺功能和吸烟的关系

HDAC inhibitors block the removal of these acetyl groups .

HDAC抑制剂阻断了去乙酰基化过程。

Hydroxamic acid compounds are component of most of the HDAC inhibitors .

羟肟酸类抑制剂是目前研究最多的组蛋白去乙酰化酶抑制剂。

HDAC removes certain chemicals , called acetyl groups , from a wide range of proteins .

HDAC可以从很多蛋白质中去除一种叫做乙酰基的化学结构。

We further showed that PAC-320 possessed a strong inhibitory effect to intracellular HDAC activity .

我们通过进一步的实验表明PAC-320对于细胞内的HDAC也具有很强的抑制活性。

HDAC activity plays a key role in the regulation of gene expression , and HDAC is a clinically validated cancer target .

HDAC活性在基因表达的调控中发挥关键作用，HDAC是一种经过临床验证的癌症靶标。

HDAC Inhibitor Trichostatin a Promotes the Specialized Differentiation of Mesenchymal Stem Cells and Investigate to Mechanism of Acetylated Action

TSA对骨髓间充质干细胞定向分化的促进作用及机制探讨

Objective : To improve the synthetic procedure of the histone deacetylase ( HDAC ) inhibitor SAHA .

目的：改进组蛋白去乙酰化酶抑制剂SAHA的合成工艺。

However , existing HDAC inhibitors can exhibit low potency , lack of selectivity , and poor pharmacokinetic or toxicity profiles .

但现有HDAC抑制剂效度低、缺乏选择性、药代动力学或毒性特征较差。

The research progress of HDAC inhibitors systema - ( tically ) are reviewed .

该文对HDAC抑制剂的研究进展进行系统的综述。

Research shows that HDAC inhibitors have shown a good antitumor effect on a variety of tumor cells including bladder , ovarian , lung , bone , esophageal .

研究表明，HDAC抑制剂对多种肿瘤细胞，包括膀胱、卵巢、骨、食管、肺等均表现出良好的抗肿瘤作用。

HDAC inhibitors can inhibit the growth and survival of tumor cell through regulating the abnormal proliferation and ( or ) the expression of apoptosis-related gene .

HDAC抑制剂可通过调节异常增生和（或）凋亡基因的表达抑制肿瘤细胞的生长和存活。

HDAC inhibitors are a newer class of cancer drugs that can , as single agents or in combination with other anticancer agents , kill cancer cells .

HDAC抑制剂是一类较新的抗癌药，单用或与其他抗癌药联合使用时可杀死癌细胞。

The new study shows that VPA can remit leukemogenesis mediated by AML1 / ETO fusion gene through breaking abnormal function of HDAC .

研究发现VPA通过破坏异常的HDAC功能而有效地缓解AML1/ETO融合基因介导的白血病生成。

Conclusion These results suggested that HDAC was involved in the mechanism of inhibition of tyrosine hydroxylase expression in α - Syn-transfected dopaminergic neuronal cells .

结论HDAC参与了多巴胺能神经元中-αSyn抑制TH表达的机制。

With HDAC , experiments could be conducted at - 180 ℃ to 1200 ℃ and 100 ~ 10000MPa within hydrothermal system and the entire experiment process could be observed .

它可在-180～1200℃，100～10000MPa水热体系进行实验，并具直观实验全过程的特点。

The preclinical efficacy and pharmacokinetic properties of HBI-8000 may translate into an improved clinical profile over other HDAC inhibitors currently being marketed or in development .

HBI-8000的临床前有效性和药代动力学特性预示，其临床特性可能优于目前市售或开发中的其他HDAC抑制剂。

Histone deacetylase ( HDAC ) greatly affects the chromatin topology and gene expression , and HDAC can be a new strategy in human cancer or tumour therapy .

组蛋白去乙酰化酶（HDAC）对染色质分布和基因调节起着重要的作用，也是治疗癌症和其它疾病的新靶点。

Recent studies showed that some transcriptional regulators with histone acetyltransferase ( HAT ) and deacetylase ( HDAC ) activities may play a causative role in regulating gene expression .

多种具有组蛋白乙酰化酶（HAT）和组蛋白去乙酰化酶（HDAC）活性的调节因子，通过对组蛋白乙酰化过程的调节，在基因表达调控中发挥着重要作用。

The paper proposed a possible binding mode of MS-275 , a benzamide histone deacetylase ( HDAC ) inhibitor , to HDAC by intensive docking study .

通过计算机模拟的对接过程研究，发现了MS-275&一种苯甲酰胺类的组蛋白去乙酰酶（HDAC）抑制剂与酶的可能的全新结合方式。

Moreover , HDAC inhibitor TSA induced histone hyperacetylation and stimulated Sp1 binding to mda-7 promoter , which in turn enhanced the expression of mda-7 .

另外，组蛋白去乙酰化酶抑制剂TSA诱导组蛋白超乙酰化，促进Sp1与mda-7启动子结合，进而激活mda-7的表达。

The infrared spectra measurement for water has been conducted and investigated at the temperatures of 35-350 ℃ and the pressures of 1.7-2.7 GPa by using Hydrothermal Diamond Anvil Cell ( HDAC ) .

在温度35～350℃、压力17～27GPa下用水热金刚石压腔进行了水的红外光谱测量和研究。

The best method for in situ observation of the deep earth fluids is to utilized a hydrothermal diamond anvil cell ( HDAC ) connected to different spectrometers , and by using Synchrotron radiation technique .

使用金刚石压砧在高温高压下原位观测流体的实验，用谱学方法，结合同步辐射光源技术，成为定量化研究地球深部高温超高压流体的有效方法。

If CoR bind with gene abnormally and HDAC act with histone continuously , gene transcription will be inhibited . Many tumors ' occurrence and develop have the directly relations with transcription inhibition .

如果CoR与基因异常结合，使组蛋白与HDAC持续作用，将导致基因转录受抑，这种转录抑制与多种肿瘤的发生、发展有直接关系。

Modulation of core histone acetylation by histone deacetylase ( HDAC ) and histone acetyl - transferase ( HAT ) alters chromatin structure and dynamically affects transcriptional regulation .

组蛋白去乙酰酶（HistoneDeacetylase，HDAC）抑制剂可促进组蛋白乙酰化，调节染色质结构和基因转录。

Histone acetylation is an important part of epigenetics . The dynamic equilibrium between Histone acetyltransferase ( HAT ) and histone deacetylase ( HDAC ) can control the chromatin structure and gene expression .

组蛋白乙酰化修饰是表观遗传学中的重要组成部分，组蛋白乙酰化酶（HAT）和组蛋白去乙酰化酶（HDAC）之间的动态平衡控制着染色质结构和基因表达。

The aberrant transcriptional repression caused by abnormal expression of HDAC is believed to be able to act as key regulators of many diseases , including cancers , acute promyelocytic leukemia , viral and flammation .

当HDAC过度表达并被转录因子募集，就会导致特定基因的不正常抑制，从而导致癌症、急性髓性白血病、病毒和感染等的发生与发展，研究其抑制剂对上述疾病的治疗具有重要意义。