CpG island

Analysis of CpG island methylation status of E-cadherin gene in bladder cancer

膀胱癌组织中上皮细胞钙依粘连蛋白基因启动子区CpG岛甲基化状态的分析

Analysis of the methylation in CpG island by denaturing high-performance liquid chromatography

变性高效液相色谱法检测CpG岛胞嘧啶甲基化

Significance of CpG Island Methylation of MT-3 gene in Cell Lines of Esophageal Cancer

食管癌细胞系中MT-3基因CpG岛甲基化的意义

The Experimental Research on the CpG Island Methylation of Estrogen Receptor 's Promoters in Leukemia

白血病中雌激素受体启动子CpG岛甲基化的实验研究

Genes expression profile of sporadic colorectal cancer with CpG island methylator phenotype

散发性大肠癌CpG岛甲基子表型的基因表达

CpG island methylation and expression of thrombospondin 1 gene in colorectal adenocarcinoma

大肠腺癌THBS1CpG岛甲基化及其蛋白表达的研究

Effects of promoter region 5 ′ CpG island demethylation on biological phenotype in human colorectal cancer cells

启动子区5′CpG岛去甲基化对人结肠癌细胞生物学表型的影响

Study on methylation of CpG island in the promoter region of DAPK gene in gastric cancer

胃癌中DAPK基因启动子区CpG岛高甲基化的研究

The CpG island methylation status of E-cadherin was examined by means of methylation specific PCR .

采用甲基化特异聚合酶链反应（MSP）检测Ecadherin基因启动子区CpG岛的甲基化状态；

Hypermethylation of CpG island in promoter region of DNA repair gene MGMT in esophageal carcinoma

食管癌中DNA修复基因MGMT启动子区CpG岛过甲基化研究

In human cancer cells , DNA methylation mainly refers to the CpG island hypermethylation of tumor suppressor gene .

在肿瘤细胞中DNA甲基化主要指抑癌基因CpG岛的异常甲基化，这种异常甲基化抑制基因转录，使抑癌基因丧失抑癌作用。

Evaluation of a large , population-based sample supports a CpG island methylator phenotype in colon cancer

证实了结肠癌中的一项CpG岛甲基化表型：一项基于大样本人群评估

Objective To study MTS1 / p16 gene deletion and 5 ' CpG island methylation in renal carcinoma .

目的研究肾癌中p16基因状态与肾癌的关系。

CpG island hypermethylation is emerging as an important mechanism for inactivation of tumor suppressor genes in the carcinogenesis .

抑癌基因启动子区CpG岛高甲基化导致其表达沉寂，是癌症发生中的一个重要机制。

Expression of TMS1 / ASC Gene and its CpG Island Methylation Status in Transitional Cell Carcinoma of Bladder

TMS1/ASC基因CpG岛甲基化与膀胱移行细胞癌发生的关系

Objective To study the relationship between CpG island methylation of MT-3 gene and its mRNA expression in cell lines of esophageal cancer .

目的研究食管癌细胞系中MT-3基因CpG岛甲基化与其mRNA表达的关系。

The genome-wide hypomethylation and the abnormal methylation of CpG island were a common phenomenon in human tumors .

全基因组低甲基化和CpG岛的异常高甲基化是人类肿瘤中普遍存在的现象。

BACKGROUND & OBJECTIVE : Transcriptional silencing by CpG island methylation is now believed to be an important mechanism of carcinogenesis .

背景与目的：目前认为CpG岛甲基化导致转录抑制是恶性肿瘤发生的重要机制之一。

In which , the abnormal methylation of CpG island methylation that makes some tumor suppressor gene inactivation is the key to cancer .

其中，CpG岛的异常高甲基化使得一些关键的抑癌基因失活是引发癌症的重要机制。

AIM : To explore the relationship between methylation status of promoter region 5 ′ CpG island and the biological phenotype in human colorectal cancer RKO cell lines .

目的：探讨DNA启动子区5′CpG岛甲基化状态与人结肠癌RKO细胞增殖凋亡等生物学特征的关系。

The Significances of CpG Island Hypermethylation of MT-3 Gene in Carcinoma of the Esophagus and the Optimization of DNA Extraction from Tissues of Esophageal Cancer

食管癌细胞MT-3基因CpG岛超甲基化的意义以及食管癌组织DNA提取方法的优化

Most mutations is in the CpG island , which indicate again that the CpG island is the dominant mutation region in the eukaryotic genomic DNA .

从突变发生的位点来看，大部分的突变都发生在CpG岛，这再次表明在真核生物基因组DNA内CpG岛是突变的主要发生位点。

Entropy-based divergence measures have provided an impelling tool in evaluating sequence complexity , predicting CpG island , and detecting borders between coding and non-coding DNA regions etc.

在分析DNA序列复杂度、预测基因编码区和非编码的DNA边界识别等问题中，以熵为基础构造的离散量度量提供了一种强有力的工具。

Urpose 〕 To investigate the aberrant methylation of the 5 ′ CpG island in p16 / MTS1 gene in human colon carcinoma .

〔目的〕研究结肠癌组织中p16基因5′端CpG岛异常甲基化现象。

〔 Results 〕 32 % ( 9 of 28 ) colon carcinomas were found aberrant methylation in 5 ′ CpG island , but negative in 20 tumor adjacent tissues .

〔结果〕28例结肠癌组织中有9例5′端CpG岛异常甲基化（32%），而20例正常组织中均阴性。

METHODS : Hypersensitive methylation of restriction endonuclease and polymerase chain reaction were used to detect the methylation of AR gene CpG island in 96 atherosclerosis patients and ninety one control cases .

方法：应用甲基化敏感的限制性内切酶及聚合酶链式反应（PCR）对96例动脉粥样硬化患者、91例正常对照人群AR基因CpG岛甲基化模式进行比较，并进行分析。

This study was to investigate the CpG island methylation status of E-cadherin gene promoter in primary human gastric carcinomas and adjacent gastric tissues , and to explore the mechanism of gastric carcinogenesis .

我们通过检测胃癌及癌旁组织中E-cadherin基因启动子CpG岛甲基化水平，初步探讨胃癌的发病机制。

The CpG island methylation status of DAPK was examined by means of methylation specific PCR ( MSP ), and the products of MSP were subjected to TA cloning .

采用甲基化特异性PCR（methylationspecificPCR，MSP）检测DAPK基因启动子区CpG岛的甲基化状态；并对MSP产物进行TA克隆。

CpG island hypermethylation of the tumor suppressor gene is the most common molecule change of CRC , and hypermethylation of the several genes is closely related to occurrence and development of CRC .

肿瘤抑制基因CpG岛的超甲基化是大肠肿瘤发生的最常见的分子改变，许多基因的超甲基化与大肠癌的发生发展密切相关。

Recent studies show that the existence of inactivation in many tumors , including lung cancer , cholangiocarcinoma , pancreatic cancer and hepatocellular carcinoma , with its mechanism of inactivation of the gene promoter region CpG island methylation .

目前研究发现在许多肿瘤中存在RUNX3的失活，包括胃癌、肺癌、胆管癌、胰腺癌和肝细胞癌等，其失活的机制主要是基因启动子区域CpG岛的甲基化。